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New approaches for treating staphylococcal biofilm infections.

Abstract

Bacteria of the genus Staphylococcus are a prominent cause of acute and chronic infections. The ability of the staphylococci to establish biofilms has been linked to the persistence of chronic infections, which has drawn considerable interest from researchers over the past decade. Biofilms can be defined as sessile communities of surface-attached cells encased in an extracellular matrix, and treatment of bacteria in this mode of growth is challenging due to the resistance of biofilm structures to both antimicrobials and host defenses. In this review of the literature, we introduce Staphylococcus aureus and Staphylococcus epidermidis biofilms and summarize current antibiotic treatment approaches for staphylococcal biofilm infections. We also review recent studies on alternative strategies for preventing biofilm formation and dispersing established biofilms, including matrix-degrading enzymes, small-molecule approaches, and manipulation of natural staphylococcal disassembly mechanisms. While research on staphylococcal biofilm development is still in its early stages, new discoveries in the field hold promise for improved therapies that target staphylococcal biofilm infections.

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    MeSH

    Anti-Bacterial Agents
    Biofilms
    Catheter-Related Infections
    Enzymes
    Humans
    Methicillin-Resistant Staphylococcus aureus
    Nucleic Acid Synthesis Inhibitors
    Prosthesis-Related Infections
    Protein Synthesis Inhibitors
    Quorum Sensing
    Staphylococcal Infections
    Staphylococcus aureus
    Staphylococcus epidermidis
    Tetracyclines

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Review

    Language

    eng

    PubMed ID

    22191529

    Citation

    TY - JOUR T1 - New approaches for treating staphylococcal biofilm infections. AU - Kiedrowski,Megan R, AU - Horswill,Alexander R, PY - 2011/12/24/entrez PY - 2011/12/24/pubmed PY - 2012/2/14/medline SP - 104 EP - 21 JF - Annals of the New York Academy of Sciences JO - Ann. N. Y. Acad. Sci. VL - 1241 N2 - Bacteria of the genus Staphylococcus are a prominent cause of acute and chronic infections. The ability of the staphylococci to establish biofilms has been linked to the persistence of chronic infections, which has drawn considerable interest from researchers over the past decade. Biofilms can be defined as sessile communities of surface-attached cells encased in an extracellular matrix, and treatment of bacteria in this mode of growth is challenging due to the resistance of biofilm structures to both antimicrobials and host defenses. In this review of the literature, we introduce Staphylococcus aureus and Staphylococcus epidermidis biofilms and summarize current antibiotic treatment approaches for staphylococcal biofilm infections. We also review recent studies on alternative strategies for preventing biofilm formation and dispersing established biofilms, including matrix-degrading enzymes, small-molecule approaches, and manipulation of natural staphylococcal disassembly mechanisms. While research on staphylococcal biofilm development is still in its early stages, new discoveries in the field hold promise for improved therapies that target staphylococcal biofilm infections. SN - 1749-6632 UR - https://www.unboundmedicine.com/medline/citation/22191529/full_citation/New_approaches_for_treating_staphylococcal_biofilm_infections_ L2 - http://dx.doi.org/10.1111/j.1749-6632.2011.06281.x ER -