Tags

Type your tag names separated by a space and hit enter

The long-term effect of statins on the risk of new-onset diabetes mellitus in elderly Taiwanese patients with hypertension and dyslipidaemia: a retrospective longitudinal cohort study.

Abstract

BACKGROUND

HMG-CoA reductase inhibitors (statins) have been linked to new-onset diabetes (NOD). Individual statins may differ in the extent to which they increase the risk for NOD; however, the effect of statins on the development of NOD in elderly hypertensive and dyslipidaemic patients has not been well studied.

OBJECTIVE

The aim of this study was to investigate the relative risk for NOD among elderly (age ≥65 years) hypertensive and dyslipidaemic Taiwanese patients who received different statins.

METHODS

This was a retrospective cohort study performed using data from claim forms provided to the central regional branch of the Bureau of National Health Insurance in Taiwan from July 2004 to December 2009. Prescriptions for statins before the index date were retrieved from a prescription database. We estimated the hazard ratios (HRs) of NOD associated with statin use. Non-diabetic subjects served as the reference group.

RESULTS

A total of 2735 NOD cases were identified among 15,637 elderly hypertensive and dyslipidaemic patients during the study period. The risk of NOD after adjusting for sex, age, concomitant medication and mean dose of prescription was lower among users of atorvastatin (HR 0.77; 95% CI 0.71, 0.83) and rosuvastatin (HR 0.65; 95% CI 0.51, 0.82) than among non-users. Patients who took lovastatin (HR 1.38; 95% CI 1.26, 1.50) or simvastatin (HR 1.30; 95% CI 1.14, 1.48) were at higher risk of developing NOD than non-users. Pravastatin and fluvastatin were not associated with increased risk of NOD.

CONCLUSIONS

The results of this study suggest that elderly hypertensive and dyslipidaemic patients who take atorvastatin or rosuvastatin are at lower risk of NOD. Lovastatin and simvastatin were associated with a significant increase in the risk of NOD.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Health Service Management, China Medical University, Taichung, Taiwan, ROC.

    , , ,

    Source

    Drugs & aging 29:1 2012 Jan 01 pg 45-51

    MeSH

    Aged
    Aged, 80 and over
    Diabetes Mellitus
    Dyslipidemias
    Female
    Humans
    Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Hypertension
    Longitudinal Studies
    Male
    Retrospective Studies
    Risk
    Taiwan

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22191722

    Citation

    Ma, Tsochiang, et al. "The Long-term Effect of Statins On the Risk of New-onset Diabetes Mellitus in Elderly Taiwanese Patients With Hypertension and Dyslipidaemia: a Retrospective Longitudinal Cohort Study." Drugs & Aging, vol. 29, no. 1, 2012, pp. 45-51.
    Ma T, Chang MH, Tien L, et al. The long-term effect of statins on the risk of new-onset diabetes mellitus in elderly Taiwanese patients with hypertension and dyslipidaemia: a retrospective longitudinal cohort study. Drugs Aging. 2012;29(1):45-51.
    Ma, T., Chang, M. H., Tien, L., Liou, Y. S., & Jong, G. P. (2012). The long-term effect of statins on the risk of new-onset diabetes mellitus in elderly Taiwanese patients with hypertension and dyslipidaemia: a retrospective longitudinal cohort study. Drugs & Aging, 29(1), pp. 45-51. doi:10.2165/11597250-000000000-00000.
    Ma T, et al. The Long-term Effect of Statins On the Risk of New-onset Diabetes Mellitus in Elderly Taiwanese Patients With Hypertension and Dyslipidaemia: a Retrospective Longitudinal Cohort Study. Drugs Aging. 2012 Jan 1;29(1):45-51. PubMed PMID: 22191722.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The long-term effect of statins on the risk of new-onset diabetes mellitus in elderly Taiwanese patients with hypertension and dyslipidaemia: a retrospective longitudinal cohort study. AU - Ma,Tsochiang, AU - Chang,Mu-Hsin, AU - Tien,Liyun, AU - Liou,Yi-Sheng, AU - Jong,Gwo-Ping, PY - 2011/12/24/entrez PY - 2011/12/24/pubmed PY - 2012/7/17/medline SP - 45 EP - 51 JF - Drugs & aging JO - Drugs Aging VL - 29 IS - 1 N2 - BACKGROUND: HMG-CoA reductase inhibitors (statins) have been linked to new-onset diabetes (NOD). Individual statins may differ in the extent to which they increase the risk for NOD; however, the effect of statins on the development of NOD in elderly hypertensive and dyslipidaemic patients has not been well studied. OBJECTIVE: The aim of this study was to investigate the relative risk for NOD among elderly (age ≥65 years) hypertensive and dyslipidaemic Taiwanese patients who received different statins. METHODS: This was a retrospective cohort study performed using data from claim forms provided to the central regional branch of the Bureau of National Health Insurance in Taiwan from July 2004 to December 2009. Prescriptions for statins before the index date were retrieved from a prescription database. We estimated the hazard ratios (HRs) of NOD associated with statin use. Non-diabetic subjects served as the reference group. RESULTS: A total of 2735 NOD cases were identified among 15,637 elderly hypertensive and dyslipidaemic patients during the study period. The risk of NOD after adjusting for sex, age, concomitant medication and mean dose of prescription was lower among users of atorvastatin (HR 0.77; 95% CI 0.71, 0.83) and rosuvastatin (HR 0.65; 95% CI 0.51, 0.82) than among non-users. Patients who took lovastatin (HR 1.38; 95% CI 1.26, 1.50) or simvastatin (HR 1.30; 95% CI 1.14, 1.48) were at higher risk of developing NOD than non-users. Pravastatin and fluvastatin were not associated with increased risk of NOD. CONCLUSIONS: The results of this study suggest that elderly hypertensive and dyslipidaemic patients who take atorvastatin or rosuvastatin are at lower risk of NOD. Lovastatin and simvastatin were associated with a significant increase in the risk of NOD. SN - 1179-1969 UR - https://www.unboundmedicine.com/medline/citation/22191722/The_long_term_effect_of_statins_on_the_risk_of_new_onset_diabetes_mellitus_in_elderly_Taiwanese_patients_with_hypertension_and_dyslipidaemia:_a_retrospective_longitudinal_cohort_study_ L2 - https://dx.doi.org/10.2165/11597250-000000000-00000 DB - PRIME DP - Unbound Medicine ER -