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Tocopherols and tocotrienols plasma levels are associated with cognitive impairment.

Abstract

Vitamin E includes 8 natural compounds (4 tocopherols, 4 tocotrienols) with potential neuroprotective activity. α-Tocopherol has mainly been investigated in relation to cognitive impairment. We examined the relation of all plasma vitamin E forms and markers of vitamin E damage (α-tocopherylquinone, 5-nitro-γ-tocopherol) to mild cognitive impairment (MCI) and Alzheimer's disease (AD). Within the AddNeuroMed-Project, plasma tocopherols, tocotrienols, α-tocopherylquinone, and 5-nitro-γ-tocopherol were assessed in 168 AD cases, 166 MCI, and 187 cognitively normal (CN) people. Compared with cognitively normal subjects, AD and MCI had lower levels of total tocopherols, total tocotrienols, and total vitamin E. In multivariable-polytomous-logistic regression analysis, both MCI and AD cases had 85% lower odds to be in the highest tertile of total tocopherols and total vitamin E, and they were, respectively, 92% and 94% less likely to be in the highest tertile of total tocotrienols than the lowest tertile. Further, both disorders were associated with increased vitamin E damage. Low plasma tocopherols and tocotrienols levels are associated with increased odds of MCI and AD.

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  • Authors+Show Affiliations

    ,

    Aging Research Center, Karolinska Institutet, Stockholm, Sweden. francesca.mangialasche@ki.se

    , , , , , , , , , , , , , ,

    Source

    Neurobiology of aging 33:10 2012 Oct pg 2282-90

    MeSH

    Aged
    Aged, 80 and over
    Alzheimer Disease
    Cognitive Dysfunction
    Female
    Humans
    Male
    Tocopherols
    Tocotrienols

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22192241

    Citation

    Mangialasche, Francesca, et al. "Tocopherols and Tocotrienols Plasma Levels Are Associated With Cognitive Impairment." Neurobiology of Aging, vol. 33, no. 10, 2012, pp. 2282-90.
    Mangialasche F, Xu W, Kivipelto M, et al. Tocopherols and tocotrienols plasma levels are associated with cognitive impairment. Neurobiol Aging. 2012;33(10):2282-90.
    Mangialasche, F., Xu, W., Kivipelto, M., Costanzi, E., Ercolani, S., Pigliautile, M., ... Mecocci, P. (2012). Tocopherols and tocotrienols plasma levels are associated with cognitive impairment. Neurobiology of Aging, 33(10), pp. 2282-90. doi:10.1016/j.neurobiolaging.2011.11.019.
    Mangialasche F, et al. Tocopherols and Tocotrienols Plasma Levels Are Associated With Cognitive Impairment. Neurobiol Aging. 2012;33(10):2282-90. PubMed PMID: 22192241.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Tocopherols and tocotrienols plasma levels are associated with cognitive impairment. AU - Mangialasche,Francesca, AU - Xu,Weili, AU - Kivipelto,Miia, AU - Costanzi,Emanuela, AU - Ercolani,Sara, AU - Pigliautile,Martina, AU - Cecchetti,Roberta, AU - Baglioni,Mauro, AU - Simmons,Andrew, AU - Soininen,Hilkka, AU - Tsolaki,Magda, AU - Kloszewska,Iwona, AU - Vellas,Bruno, AU - Lovestone,Simon, AU - Mecocci,Patrizia, AU - ,, Y1 - 2011/12/20/ PY - 2011/07/20/received PY - 2011/11/10/revised PY - 2011/11/12/accepted PY - 2011/12/24/entrez PY - 2011/12/24/pubmed PY - 2013/1/23/medline SP - 2282 EP - 90 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 33 IS - 10 N2 - Vitamin E includes 8 natural compounds (4 tocopherols, 4 tocotrienols) with potential neuroprotective activity. α-Tocopherol has mainly been investigated in relation to cognitive impairment. We examined the relation of all plasma vitamin E forms and markers of vitamin E damage (α-tocopherylquinone, 5-nitro-γ-tocopherol) to mild cognitive impairment (MCI) and Alzheimer's disease (AD). Within the AddNeuroMed-Project, plasma tocopherols, tocotrienols, α-tocopherylquinone, and 5-nitro-γ-tocopherol were assessed in 168 AD cases, 166 MCI, and 187 cognitively normal (CN) people. Compared with cognitively normal subjects, AD and MCI had lower levels of total tocopherols, total tocotrienols, and total vitamin E. In multivariable-polytomous-logistic regression analysis, both MCI and AD cases had 85% lower odds to be in the highest tertile of total tocopherols and total vitamin E, and they were, respectively, 92% and 94% less likely to be in the highest tertile of total tocotrienols than the lowest tertile. Further, both disorders were associated with increased vitamin E damage. Low plasma tocopherols and tocotrienols levels are associated with increased odds of MCI and AD. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/22192241/Tocopherols_and_tocotrienols_plasma_levels_are_associated_with_cognitive_impairment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(11)00498-2 DB - PRIME DP - Unbound Medicine ER -