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Tocopherols and tocotrienols plasma levels are associated with cognitive impairment.
Neurobiol Aging. 2012 Oct; 33(10):2282-90.NA

Abstract

Vitamin E includes 8 natural compounds (4 tocopherols, 4 tocotrienols) with potential neuroprotective activity. α-Tocopherol has mainly been investigated in relation to cognitive impairment. We examined the relation of all plasma vitamin E forms and markers of vitamin E damage (α-tocopherylquinone, 5-nitro-γ-tocopherol) to mild cognitive impairment (MCI) and Alzheimer's disease (AD). Within the AddNeuroMed-Project, plasma tocopherols, tocotrienols, α-tocopherylquinone, and 5-nitro-γ-tocopherol were assessed in 168 AD cases, 166 MCI, and 187 cognitively normal (CN) people. Compared with cognitively normal subjects, AD and MCI had lower levels of total tocopherols, total tocotrienols, and total vitamin E. In multivariable-polytomous-logistic regression analysis, both MCI and AD cases had 85% lower odds to be in the highest tertile of total tocopherols and total vitamin E, and they were, respectively, 92% and 94% less likely to be in the highest tertile of total tocotrienols than the lowest tertile. Further, both disorders were associated with increased vitamin E damage. Low plasma tocopherols and tocotrienols levels are associated with increased odds of MCI and AD.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Mangialasche F
Aging Research Center, Karolinska Institutet, Stockholm, Sweden. francesca.mangialasche@ki.se
Xu W
No affiliation info available
Kivipelto M
No affiliation info available
Costanzi E
No affiliation info available
Ercolani S
No affiliation info available
Pigliautile M
No affiliation info available
Cecchetti R
No affiliation info available
Baglioni M
No affiliation info available
Simmons A
No affiliation info available
Soininen H
No affiliation info available
Tsolaki M
No affiliation info available
Kloszewska I
No affiliation info available
Vellas B
No affiliation info available
Lovestone S
No affiliation info available
Mecocci P
No affiliation info available
AddNeuroMed Consortium
No affiliation info available

MeSH

AgedAged, 80 and overAlzheimer DiseaseCognitive DysfunctionFemaleHumansMaleTocopherolsTocotrienols

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22192241

Citation

Mangialasche, Francesca, et al. "Tocopherols and Tocotrienols Plasma Levels Are Associated With Cognitive Impairment." Neurobiology of Aging, vol. 33, no. 10, 2012, pp. 2282-90.
Mangialasche F, Xu W, Kivipelto M, et al. Tocopherols and tocotrienols plasma levels are associated with cognitive impairment. Neurobiol Aging. 2012;33(10):2282-90.
Mangialasche, F., Xu, W., Kivipelto, M., Costanzi, E., Ercolani, S., Pigliautile, M., Cecchetti, R., Baglioni, M., Simmons, A., Soininen, H., Tsolaki, M., Kloszewska, I., Vellas, B., Lovestone, S., & Mecocci, P. (2012). Tocopherols and tocotrienols plasma levels are associated with cognitive impairment. Neurobiology of Aging, 33(10), 2282-90. https://doi.org/10.1016/j.neurobiolaging.2011.11.019
Mangialasche F, et al. Tocopherols and Tocotrienols Plasma Levels Are Associated With Cognitive Impairment. Neurobiol Aging. 2012;33(10):2282-90. PubMed PMID: 22192241.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tocopherols and tocotrienols plasma levels are associated with cognitive impairment. AU - Mangialasche,Francesca, AU - Xu,Weili, AU - Kivipelto,Miia, AU - Costanzi,Emanuela, AU - Ercolani,Sara, AU - Pigliautile,Martina, AU - Cecchetti,Roberta, AU - Baglioni,Mauro, AU - Simmons,Andrew, AU - Soininen,Hilkka, AU - Tsolaki,Magda, AU - Kloszewska,Iwona, AU - Vellas,Bruno, AU - Lovestone,Simon, AU - Mecocci,Patrizia, AU - ,, Y1 - 2011/12/20/ PY - 2011/07/20/received PY - 2011/11/10/revised PY - 2011/11/12/accepted PY - 2011/12/24/entrez PY - 2011/12/24/pubmed PY - 2013/1/23/medline SP - 2282 EP - 90 JF - Neurobiology of aging JO - Neurobiol Aging VL - 33 IS - 10 N2 - Vitamin E includes 8 natural compounds (4 tocopherols, 4 tocotrienols) with potential neuroprotective activity. α-Tocopherol has mainly been investigated in relation to cognitive impairment. We examined the relation of all plasma vitamin E forms and markers of vitamin E damage (α-tocopherylquinone, 5-nitro-γ-tocopherol) to mild cognitive impairment (MCI) and Alzheimer's disease (AD). Within the AddNeuroMed-Project, plasma tocopherols, tocotrienols, α-tocopherylquinone, and 5-nitro-γ-tocopherol were assessed in 168 AD cases, 166 MCI, and 187 cognitively normal (CN) people. Compared with cognitively normal subjects, AD and MCI had lower levels of total tocopherols, total tocotrienols, and total vitamin E. In multivariable-polytomous-logistic regression analysis, both MCI and AD cases had 85% lower odds to be in the highest tertile of total tocopherols and total vitamin E, and they were, respectively, 92% and 94% less likely to be in the highest tertile of total tocotrienols than the lowest tertile. Further, both disorders were associated with increased vitamin E damage. Low plasma tocopherols and tocotrienols levels are associated with increased odds of MCI and AD. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/22192241/Tocopherols_and_tocotrienols_plasma_levels_are_associated_with_cognitive_impairment_ DB - PRIME DP - Unbound Medicine ER -