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Association of environmental tobacco smoke with dementia and Alzheimer's disease among never smokers.
Alzheimers Dement 2012; 8(6):590-5AD

Abstract

BACKGROUND

Environmental tobacco smoke (ETS) is known to be harmful; however, its association with dementia remains controversial and with Alzheimer's disease (AD) is unknown.

METHODS

Using a standard interview method, the author carried out a multicenter cross-sectional study of dementia in China by examining 2692 never-smoking people aged ≥60 years. Relative risks (RRs) of AD and all dementia, as diagnosed by psychiatrists, in relation to ETS were calculated in a multivariate regression model.

RESULTS

The adjusted RR for all dementia was 1.78 (95% confidence interval [CI]: 1.18-2.68). The increased risk was mainly from exposure to ETS at home (1.87, 95% CI: 1.19-2.93), and it was associated with exposure duration. The adjusted RR for AD was 2.28 (95% CI: 1.82-2.84); the matched figure for ETS exposure at home, at work, and at other places was 2.15 (95% CI: 1.69-2.74), 2.04 (95% CI: 1.72-2.42), and 1.80 (95% CI: 0.96-3.38), respectively. The association of the increased risk with a total cumulative exposure dose was at borderline significance.

CONCLUSIONS

The risk of dementia and AD increased with ETS exposure. Banning smoking in public areas may help reduce a dementia epidemic worldwide.

Authors+Show Affiliations

Division of Health and Social Care Research, King's College London, London, UK. ruoling.chen@kcl.ac.uk

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22197095

Citation

Chen, Ruoling. "Association of Environmental Tobacco Smoke With Dementia and Alzheimer's Disease Among Never Smokers." Alzheimer's & Dementia : the Journal of the Alzheimer's Association, vol. 8, no. 6, 2012, pp. 590-5.
Chen R. Association of environmental tobacco smoke with dementia and Alzheimer's disease among never smokers. Alzheimers Dement. 2012;8(6):590-5.
Chen, R. (2012). Association of environmental tobacco smoke with dementia and Alzheimer's disease among never smokers. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 8(6), pp. 590-5. doi:10.1016/j.jalz.2011.09.231.
Chen R. Association of Environmental Tobacco Smoke With Dementia and Alzheimer's Disease Among Never Smokers. Alzheimers Dement. 2012;8(6):590-5. PubMed PMID: 22197095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of environmental tobacco smoke with dementia and Alzheimer's disease among never smokers. A1 - Chen,Ruoling, Y1 - 2011/12/23/ PY - 2011/05/13/received PY - 2011/09/12/revised PY - 2011/09/19/accepted PY - 2011/12/27/entrez PY - 2011/12/27/pubmed PY - 2013/5/4/medline SP - 590 EP - 5 JF - Alzheimer's & dementia : the journal of the Alzheimer's Association JO - Alzheimers Dement VL - 8 IS - 6 N2 - BACKGROUND: Environmental tobacco smoke (ETS) is known to be harmful; however, its association with dementia remains controversial and with Alzheimer's disease (AD) is unknown. METHODS: Using a standard interview method, the author carried out a multicenter cross-sectional study of dementia in China by examining 2692 never-smoking people aged ≥60 years. Relative risks (RRs) of AD and all dementia, as diagnosed by psychiatrists, in relation to ETS were calculated in a multivariate regression model. RESULTS: The adjusted RR for all dementia was 1.78 (95% confidence interval [CI]: 1.18-2.68). The increased risk was mainly from exposure to ETS at home (1.87, 95% CI: 1.19-2.93), and it was associated with exposure duration. The adjusted RR for AD was 2.28 (95% CI: 1.82-2.84); the matched figure for ETS exposure at home, at work, and at other places was 2.15 (95% CI: 1.69-2.74), 2.04 (95% CI: 1.72-2.42), and 1.80 (95% CI: 0.96-3.38), respectively. The association of the increased risk with a total cumulative exposure dose was at borderline significance. CONCLUSIONS: The risk of dementia and AD increased with ETS exposure. Banning smoking in public areas may help reduce a dementia epidemic worldwide. SN - 1552-5279 UR - https://www.unboundmedicine.com/medline/citation/22197095/Association_of_environmental_tobacco_smoke_with_dementia_and_Alzheimer's_disease_among_never_smokers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1552-5260(11)02961-X DB - PRIME DP - Unbound Medicine ER -