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Possible role of dopamine D1-like and D2-like receptors in behavioural activation and "contingent" reward evaluation in sodium-replete and sodium-depleted rats licking for NaCl solutions.
Pharmacol Biochem Behav. 2012 Mar; 101(1):99-106.PB

Abstract

Based on the different effects of the dopamine D1-like and D2-like receptor antagonists SCH 23390 and raclopride on the measures of licking microstructure in rats, we suggested that the level of activation of reward-associated responses depends on dopamine D1-like receptor stimulation, and is updated, or "reboosted", on the basis of a dopamine D2-like receptor-mediated reward evaluation. To further test this hypothesis, we examined the effects of the dopamine D2-like receptor antagonist raclopride (0, 25, 125, 250μg/kg) and of the dopamine D1-like receptor antagonist SCH 23390 (0, 10, 20 and 40μg/kg) on the microstructure of licking for two different NaCl solutions (0.9% and 2.7%) in rats in sodium-replete status and in the sodium-depleted status induced by the diuretic drug furosemide. Rats were exposed to each solution for 180 seconds after the first lick. Both in sodium-replete and in sodium-depleted status, SCH 23390 produced a decrease of burst number, a measure of behavioural activation, without affecting their size, a measure of reward evaluation. Raclopride reduced burst number but appeared also to exert some effects on burst size. Sodium depletion resulted in an increased intake for both NaCl solutions due to an increase in burst number and size, and in a reduced sensitivity to the effect of raclopride on lick number. These results are not in contrast with the proposed hypothesis and are consistent with previous evidence suggesting a role for dopamine D2-like receptors in the increased NaCl appetite induced by sodium depletion.

Authors+Show Affiliations

Dipartimento di Scienze del Farmaco, Università di Sassari, Sassari, Italy. dsfpaolo@uniss.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22197709

Citation

D'Aquila, Paolo S., et al. "Possible Role of Dopamine D1-like and D2-like Receptors in Behavioural Activation and "contingent" Reward Evaluation in Sodium-replete and Sodium-depleted Rats Licking for NaCl Solutions." Pharmacology, Biochemistry, and Behavior, vol. 101, no. 1, 2012, pp. 99-106.
D'Aquila PS, Rossi R, Rizzi A, et al. Possible role of dopamine D1-like and D2-like receptors in behavioural activation and "contingent" reward evaluation in sodium-replete and sodium-depleted rats licking for NaCl solutions. Pharmacol Biochem Behav. 2012;101(1):99-106.
D'Aquila, P. S., Rossi, R., Rizzi, A., & Galistu, A. (2012). Possible role of dopamine D1-like and D2-like receptors in behavioural activation and "contingent" reward evaluation in sodium-replete and sodium-depleted rats licking for NaCl solutions. Pharmacology, Biochemistry, and Behavior, 101(1), 99-106. https://doi.org/10.1016/j.pbb.2011.12.004
D'Aquila PS, et al. Possible Role of Dopamine D1-like and D2-like Receptors in Behavioural Activation and "contingent" Reward Evaluation in Sodium-replete and Sodium-depleted Rats Licking for NaCl Solutions. Pharmacol Biochem Behav. 2012;101(1):99-106. PubMed PMID: 22197709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible role of dopamine D1-like and D2-like receptors in behavioural activation and "contingent" reward evaluation in sodium-replete and sodium-depleted rats licking for NaCl solutions. AU - D'Aquila,Paolo S, AU - Rossi,Roberta, AU - Rizzi,Antonella, AU - Galistu,Adriana, Y1 - 2011/12/14/ PY - 2011/05/05/received PY - 2011/12/05/revised PY - 2011/12/10/accepted PY - 2011/12/27/entrez PY - 2011/12/27/pubmed PY - 2012/5/26/medline SP - 99 EP - 106 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 101 IS - 1 N2 - Based on the different effects of the dopamine D1-like and D2-like receptor antagonists SCH 23390 and raclopride on the measures of licking microstructure in rats, we suggested that the level of activation of reward-associated responses depends on dopamine D1-like receptor stimulation, and is updated, or "reboosted", on the basis of a dopamine D2-like receptor-mediated reward evaluation. To further test this hypothesis, we examined the effects of the dopamine D2-like receptor antagonist raclopride (0, 25, 125, 250μg/kg) and of the dopamine D1-like receptor antagonist SCH 23390 (0, 10, 20 and 40μg/kg) on the microstructure of licking for two different NaCl solutions (0.9% and 2.7%) in rats in sodium-replete status and in the sodium-depleted status induced by the diuretic drug furosemide. Rats were exposed to each solution for 180 seconds after the first lick. Both in sodium-replete and in sodium-depleted status, SCH 23390 produced a decrease of burst number, a measure of behavioural activation, without affecting their size, a measure of reward evaluation. Raclopride reduced burst number but appeared also to exert some effects on burst size. Sodium depletion resulted in an increased intake for both NaCl solutions due to an increase in burst number and size, and in a reduced sensitivity to the effect of raclopride on lick number. These results are not in contrast with the proposed hypothesis and are consistent with previous evidence suggesting a role for dopamine D2-like receptors in the increased NaCl appetite induced by sodium depletion. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/22197709/Possible_role_of_dopamine_D1_like_and_D2_like_receptors_in_behavioural_activation_and_"contingent"_reward_evaluation_in_sodium_replete_and_sodium_depleted_rats_licking_for_NaCl_solutions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(11)00383-2 DB - PRIME DP - Unbound Medicine ER -