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Correlation of vitamin E, uric acid, and diet composition with histologic features of pediatric NAFLD.
J Pediatr Gastroenterol Nutr 2012; 54(1):90-6JP

Abstract

OBJECTIVES

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children in the United States. Although changes in diet are often recommended to improve NAFLD, little is known regarding the influence of diet on histologic features of the disease.

SUBJECTS AND METHODS

This was a prospective, cross-sectional registry-based study. Children (n = 149) enrolled in the multicenter nonalcoholic steatohepatitis (NASH) Clinical Research Network had demographic, anthropometric, clinical, laboratory, and histology data obtained, including the Block Brief Food Questionnaire. Subjects were grouped by presence or absence of steatohepatitis and grades of histologic features according to NASH Clinical Research Network criteria.

RESULTS

No significant differences were found between children with steatosis compared with steatohepatitis for fraction of energy from fat, carbohydrates, and protein. Sugar-sweetened beverage consumption was low and did not correlate with histologic features, although uric acid, a surrogate marker for fructose intake, was significantly increased in those with definite NASH (P = 0.008). For all groups, vitamin E consumption was insufficient compared with the recommended daily allowance. Median consumption of vitamin E was lower in children with higher grade of steatosis (8.4 vs 6.1 vs 6.9 for grades I, II, and III, respectively, P = 0.05). Those consuming less vitamin C had increased ballooning degeneration (P = 0.05).

CONCLUSIONS

Children with NAFLD have a diet that is insufficient in vitamin E and this may contribute to the pathophysiology of NAFLD. In children with NAFLD, reported sugar-sweetened beverage consumption is low; however, uric acid, which may reflect total fructose consumption, was significantly associated with NASH and should be further evaluated.

Authors+Show Affiliations

Pediatrics, Emory University, Atlanta, GA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22197855

Citation

Vos, Miriam B., et al. "Correlation of Vitamin E, Uric Acid, and Diet Composition With Histologic Features of Pediatric NAFLD." Journal of Pediatric Gastroenterology and Nutrition, vol. 54, no. 1, 2012, pp. 90-6.
Vos MB, Colvin R, Belt P, et al. Correlation of vitamin E, uric acid, and diet composition with histologic features of pediatric NAFLD. J Pediatr Gastroenterol Nutr. 2012;54(1):90-6.
Vos, M. B., Colvin, R., Belt, P., Molleston, J. P., Murray, K. F., Rosenthal, P., ... Lavine, J. E. (2012). Correlation of vitamin E, uric acid, and diet composition with histologic features of pediatric NAFLD. Journal of Pediatric Gastroenterology and Nutrition, 54(1), pp. 90-6. doi:10.1097/MPG.0b013e318229da1a.
Vos MB, et al. Correlation of Vitamin E, Uric Acid, and Diet Composition With Histologic Features of Pediatric NAFLD. J Pediatr Gastroenterol Nutr. 2012;54(1):90-6. PubMed PMID: 22197855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation of vitamin E, uric acid, and diet composition with histologic features of pediatric NAFLD. AU - Vos,Miriam B, AU - Colvin,Ryan, AU - Belt,Patricia, AU - Molleston,Jean P, AU - Murray,Karen F, AU - Rosenthal,Philip, AU - Schwimmer,Jeffrey B, AU - Tonascia,James, AU - Unalp,Aynur, AU - Lavine,Joel E, AU - ,, PY - 2011/12/27/entrez PY - 2011/12/27/pubmed PY - 2012/5/18/medline SP - 90 EP - 6 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 54 IS - 1 N2 - OBJECTIVES: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children in the United States. Although changes in diet are often recommended to improve NAFLD, little is known regarding the influence of diet on histologic features of the disease. SUBJECTS AND METHODS: This was a prospective, cross-sectional registry-based study. Children (n = 149) enrolled in the multicenter nonalcoholic steatohepatitis (NASH) Clinical Research Network had demographic, anthropometric, clinical, laboratory, and histology data obtained, including the Block Brief Food Questionnaire. Subjects were grouped by presence or absence of steatohepatitis and grades of histologic features according to NASH Clinical Research Network criteria. RESULTS: No significant differences were found between children with steatosis compared with steatohepatitis for fraction of energy from fat, carbohydrates, and protein. Sugar-sweetened beverage consumption was low and did not correlate with histologic features, although uric acid, a surrogate marker for fructose intake, was significantly increased in those with definite NASH (P = 0.008). For all groups, vitamin E consumption was insufficient compared with the recommended daily allowance. Median consumption of vitamin E was lower in children with higher grade of steatosis (8.4 vs 6.1 vs 6.9 for grades I, II, and III, respectively, P = 0.05). Those consuming less vitamin C had increased ballooning degeneration (P = 0.05). CONCLUSIONS: Children with NAFLD have a diet that is insufficient in vitamin E and this may contribute to the pathophysiology of NAFLD. In children with NAFLD, reported sugar-sweetened beverage consumption is low; however, uric acid, which may reflect total fructose consumption, was significantly associated with NASH and should be further evaluated. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/22197855/Correlation_of_vitamin_E_uric_acid_and_diet_composition_with_histologic_features_of_pediatric_NAFLD_ L2 - http://dx.doi.org/10.1097/MPG.0b013e318229da1a DB - PRIME DP - Unbound Medicine ER -