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Role for monoaminergic systems in the antidepressant-like effect of ethanol extracts from Hemerocallis citrina.
J Ethnopharmacol. 2012 Feb 15; 139(3):780-7.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Hemerocallis citrina, a traditional herbal medicine, has been used for the improvement of emotions in Eastern-Asia countries.

AIM OF THE STUDY

Herein, we explored the antidepressant-like effect and its monoaminergic mechanism of the ethanol extracts from Hemerocallis citrina (HCE).

MATERIALS AND METHODS

Effect of HCE (90, 180 and 360 mg/kg, p.o.) on the immobility time was assessed in the mouse forced swim test (FST) and tail suspension test (TST), and locomotor activity was evaluated in the open-field test (OFT). Additionally, the monoamine neurotransmitters serotonin (5-HT), noradrenaline (NA) and dopamine (DA) levels involved in the antidepressant-like effect of HCE were also measured in the mice brain regions of frontal cortex and hippocampus.

RESULTS

HCE (90, 180 and 360 mg/kg, p.o.) administration significantly reduced the immobility time in both the FST and TST without accompanying changes in locomotor activity in the OFT. The pretreatment of mice with WAY 100635 (0.1 mg/kg, s.c., a 5-HT(1A) receptor antagonist), cyproheptadine (3 mg/kg, i.p., a 5-HT(2) receptor antagonist), prazosin (62.5 μg/kg, i.p., an α(1)-adrenoceptor antagonist), yohimbine (1 mg/kg, i.p., an α(2)-adrenoceptor antagonist), propranolol (5 mg/kg, i.p., a β-adrenoceptor antagonist) or sulpiride (50 mg/kg, i.p., a dopamine D(2) receptor antagonist), but not SCH23390 (0.05 mg/kg, s.c., a dopamine D(1) receptor antagonist) prevented the antidepressant-like effect of HCE (360 mg/kg, p.o.) in the TST. In addition, HCE enhanced 5-HT and NA levels in the frontal cortex and hippocampus as well as elevated DA levels in the frontal cortex.

CONCLUSION

The results indicate that the antidepressant-like effect of HCE is dependent on the serotonergic (5-HT(1A) and 5-HT(2) receptors), noradrenergic (α(1)-, α(2)- and β-adrenoceptors) and dopaminergic (D(2) receptor) systems as well as the elevation of 5-HT, NA and DA levels in the mouse brain.

Authors+Show Affiliations

Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian Province, PR China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22197914

Citation

Gu, Lan, et al. "Role for Monoaminergic Systems in the Antidepressant-like Effect of Ethanol Extracts From Hemerocallis Citrina." Journal of Ethnopharmacology, vol. 139, no. 3, 2012, pp. 780-7.
Gu L, Liu YJ, Wang YB, et al. Role for monoaminergic systems in the antidepressant-like effect of ethanol extracts from Hemerocallis citrina. J Ethnopharmacol. 2012;139(3):780-7.
Gu, L., Liu, Y. J., Wang, Y. B., & Yi, L. T. (2012). Role for monoaminergic systems in the antidepressant-like effect of ethanol extracts from Hemerocallis citrina. Journal of Ethnopharmacology, 139(3), 780-7. https://doi.org/10.1016/j.jep.2011.11.059
Gu L, et al. Role for Monoaminergic Systems in the Antidepressant-like Effect of Ethanol Extracts From Hemerocallis Citrina. J Ethnopharmacol. 2012 Feb 15;139(3):780-7. PubMed PMID: 22197914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role for monoaminergic systems in the antidepressant-like effect of ethanol extracts from Hemerocallis citrina. AU - Gu,Lan, AU - Liu,Yan-Jun, AU - Wang,Yao-Bin, AU - Yi,Li-Tao, Y1 - 2011/12/14/ PY - 2011/06/27/received PY - 2011/11/18/revised PY - 2011/11/29/accepted PY - 2011/12/27/entrez PY - 2011/12/27/pubmed PY - 2012/6/14/medline SP - 780 EP - 7 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 139 IS - 3 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Hemerocallis citrina, a traditional herbal medicine, has been used for the improvement of emotions in Eastern-Asia countries. AIM OF THE STUDY: Herein, we explored the antidepressant-like effect and its monoaminergic mechanism of the ethanol extracts from Hemerocallis citrina (HCE). MATERIALS AND METHODS: Effect of HCE (90, 180 and 360 mg/kg, p.o.) on the immobility time was assessed in the mouse forced swim test (FST) and tail suspension test (TST), and locomotor activity was evaluated in the open-field test (OFT). Additionally, the monoamine neurotransmitters serotonin (5-HT), noradrenaline (NA) and dopamine (DA) levels involved in the antidepressant-like effect of HCE were also measured in the mice brain regions of frontal cortex and hippocampus. RESULTS: HCE (90, 180 and 360 mg/kg, p.o.) administration significantly reduced the immobility time in both the FST and TST without accompanying changes in locomotor activity in the OFT. The pretreatment of mice with WAY 100635 (0.1 mg/kg, s.c., a 5-HT(1A) receptor antagonist), cyproheptadine (3 mg/kg, i.p., a 5-HT(2) receptor antagonist), prazosin (62.5 μg/kg, i.p., an α(1)-adrenoceptor antagonist), yohimbine (1 mg/kg, i.p., an α(2)-adrenoceptor antagonist), propranolol (5 mg/kg, i.p., a β-adrenoceptor antagonist) or sulpiride (50 mg/kg, i.p., a dopamine D(2) receptor antagonist), but not SCH23390 (0.05 mg/kg, s.c., a dopamine D(1) receptor antagonist) prevented the antidepressant-like effect of HCE (360 mg/kg, p.o.) in the TST. In addition, HCE enhanced 5-HT and NA levels in the frontal cortex and hippocampus as well as elevated DA levels in the frontal cortex. CONCLUSION: The results indicate that the antidepressant-like effect of HCE is dependent on the serotonergic (5-HT(1A) and 5-HT(2) receptors), noradrenergic (α(1)-, α(2)- and β-adrenoceptors) and dopaminergic (D(2) receptor) systems as well as the elevation of 5-HT, NA and DA levels in the mouse brain. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/22197914/Role_for_monoaminergic_systems_in_the_antidepressant_like_effect_of_ethanol_extracts_from_Hemerocallis_citrina_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(11)00894-4 DB - PRIME DP - Unbound Medicine ER -