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Endurance training decreases the non-linearity in the oxygen uptake-power output relationship in humans.
Exp Physiol. 2012 Mar; 97(3):386-99.EP

Abstract

In this study, we hypothesized that 5 weeks of cycling endurance training can decrease the magnitude of the non-proportional increase in oxygen uptake (V(O(2))) to power output relationship (V(O(2)) 'excess') at exercise intensities exceeding the lactate threshold (LT). Ten untrained, physically active men performed a bout of incremental cycling exercise until exhaustion before and after training. The mitochondrial DNA copy number, myosin heavy chain composition and content of uncoupling protein 3 and sarcoplasmic reticulum Ca(2+)-ATPases (SERCAs) were analysed in muscle biopsies taken from vastus lateralis before and after training. The training resulted in an enhancement of the power-generating capabilities at maximal oxygen uptake (V(O(2)max)) by ∼7% (P = 0.002) despite there being no changes in V(O(2)max) (P = 0.49). This effect was due to a considerable reduction in the magnitude of the V(O(2)) 'excess' (P < 0.05) above the LT. A decrease in plasma ammonia concentration was found during exercise after training (P < 0.05). A downregulation of SERCA2 in vastus lateralis (P = 0.006) was observed after training. No changes in myosin heavy chain composition, selected electron transport chain proteins, uncoupling protein 3 or the mitochondrial DNA copy number (P > 0.05) were found after training. We conclude that the training-induced increase in power-generating capabilities at V(O(2)max) was due to attenuation of the V(O(2)) 'excess' above the LT. This adaptive response seems to be related to the improvement of muscle metabolic stability, as judged by a lowering of plasma ammonia concentration. The enhancement of muscle metabolic stability after training could be caused by a decrease in ATP usage at a given power output owing to downregulation of SERCA2 pumps.

Authors+Show Affiliations

Department of Physiology and Biochemistry, Faculty of Rehabilitation, University School of Physical Education, Krakow, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22198015

Citation

Majerczak, Joanna, et al. "Endurance Training Decreases the Non-linearity in the Oxygen Uptake-power Output Relationship in Humans." Experimental Physiology, vol. 97, no. 3, 2012, pp. 386-99.
Majerczak J, Korostynski M, Nieckarz Z, et al. Endurance training decreases the non-linearity in the oxygen uptake-power output relationship in humans. Exp Physiol. 2012;97(3):386-99.
Majerczak, J., Korostynski, M., Nieckarz, Z., Szkutnik, Z., Duda, K., & Zoladz, J. A. (2012). Endurance training decreases the non-linearity in the oxygen uptake-power output relationship in humans. Experimental Physiology, 97(3), 386-99. https://doi.org/10.1113/expphysiol.2011.062992
Majerczak J, et al. Endurance Training Decreases the Non-linearity in the Oxygen Uptake-power Output Relationship in Humans. Exp Physiol. 2012;97(3):386-99. PubMed PMID: 22198015.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endurance training decreases the non-linearity in the oxygen uptake-power output relationship in humans. AU - Majerczak,Joanna, AU - Korostynski,Michal, AU - Nieckarz,Zenon, AU - Szkutnik,Zbigniew, AU - Duda,Krzysztof, AU - Zoladz,Jerzy A, Y1 - 2011/12/23/ PY - 2011/12/27/entrez PY - 2011/12/27/pubmed PY - 2012/8/3/medline SP - 386 EP - 99 JF - Experimental physiology JO - Exp. Physiol. VL - 97 IS - 3 N2 - In this study, we hypothesized that 5 weeks of cycling endurance training can decrease the magnitude of the non-proportional increase in oxygen uptake (V(O(2))) to power output relationship (V(O(2)) 'excess') at exercise intensities exceeding the lactate threshold (LT). Ten untrained, physically active men performed a bout of incremental cycling exercise until exhaustion before and after training. The mitochondrial DNA copy number, myosin heavy chain composition and content of uncoupling protein 3 and sarcoplasmic reticulum Ca(2+)-ATPases (SERCAs) were analysed in muscle biopsies taken from vastus lateralis before and after training. The training resulted in an enhancement of the power-generating capabilities at maximal oxygen uptake (V(O(2)max)) by ∼7% (P = 0.002) despite there being no changes in V(O(2)max) (P = 0.49). This effect was due to a considerable reduction in the magnitude of the V(O(2)) 'excess' (P < 0.05) above the LT. A decrease in plasma ammonia concentration was found during exercise after training (P < 0.05). A downregulation of SERCA2 in vastus lateralis (P = 0.006) was observed after training. No changes in myosin heavy chain composition, selected electron transport chain proteins, uncoupling protein 3 or the mitochondrial DNA copy number (P > 0.05) were found after training. We conclude that the training-induced increase in power-generating capabilities at V(O(2)max) was due to attenuation of the V(O(2)) 'excess' above the LT. This adaptive response seems to be related to the improvement of muscle metabolic stability, as judged by a lowering of plasma ammonia concentration. The enhancement of muscle metabolic stability after training could be caused by a decrease in ATP usage at a given power output owing to downregulation of SERCA2 pumps. SN - 1469-445X UR - https://www.unboundmedicine.com/medline/citation/22198015/Endurance_training_decreases_the_non_linearity_in_the_oxygen_uptake_power_output_relationship_in_humans_ L2 - https://doi.org/10.1113/expphysiol.2011.062992 DB - PRIME DP - Unbound Medicine ER -