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Alcohol dosing and the heart: updating clinical evidence.
Semin Thromb Hemost. 2011 Nov; 37(8):875-84.ST

Abstract

The consequences of heavy or irregular alcohol drinking have long been known. Recently, consistent information has been provided in support of an association between light/moderate alcohol consumption and protection from vascular and all-cause mortality, ischemic stroke, peripheral arterial disease, congestive heart failure, and recurrence of ischemic events. After reviewing the information with respect to major aspects of cardiovascular pathophysiology, to potential confounders and to underlying mechanisms, several concepts emerge. First, the recommended amounts of "safe alcohol drinking" in healthy individuals are up to two standard drinks (~20 g/d) for a man and up to one drink (10 g/d) for a nonpregnant woman. The overall balance for young premenopausal women, but not for older women, would be unfavorable for drinking. The risk of cancer would not outweigh potential benefits of alcohol on heart disease. Second, within the frame of a balanced pattern of dietary energy intake, patients with cardiovascular disease who drink alcohol should not exceed one or two standard drinks per day for women or up to two or three drinks per day for men. Third, the low rates of coronary heart disease among the Mediterranean people may be related to their pattern of drinking wine every day during meals. Regular drinking is associated with better outcomes than occasional (binge)/weekly drinking. Fourth, wine (ethanol with antioxidants) exhibits significantly higher anti-inflammatory effects than gin (ethanol without polyphenols), and thus in general wine should be preferred to liquor or beer.

Authors+Show Affiliations

Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. dario.diminno@hotmail.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22198852

Citation

Di Minno, Matteo Nicola Dario, et al. "Alcohol Dosing and the Heart: Updating Clinical Evidence." Seminars in Thrombosis and Hemostasis, vol. 37, no. 8, 2011, pp. 875-84.
Di Minno MN, Franchini M, Russolillo A, et al. Alcohol dosing and the heart: updating clinical evidence. Semin Thromb Hemost. 2011;37(8):875-84.
Di Minno, M. N., Franchini, M., Russolillo, A., Lupoli, R., Iervolino, S., & Di Minno, G. (2011). Alcohol dosing and the heart: updating clinical evidence. Seminars in Thrombosis and Hemostasis, 37(8), 875-84. https://doi.org/10.1055/s-0031-1297366
Di Minno MN, et al. Alcohol Dosing and the Heart: Updating Clinical Evidence. Semin Thromb Hemost. 2011;37(8):875-84. PubMed PMID: 22198852.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol dosing and the heart: updating clinical evidence. AU - Di Minno,Matteo Nicola Dario, AU - Franchini,Massimo, AU - Russolillo,Anna, AU - Lupoli,Roberta, AU - Iervolino,Salvatore, AU - Di Minno,Giovanni, Y1 - 2011/12/23/ PY - 2011/12/27/entrez PY - 2011/12/27/pubmed PY - 2012/6/29/medline SP - 875 EP - 84 JF - Seminars in thrombosis and hemostasis JO - Semin. Thromb. Hemost. VL - 37 IS - 8 N2 - The consequences of heavy or irregular alcohol drinking have long been known. Recently, consistent information has been provided in support of an association between light/moderate alcohol consumption and protection from vascular and all-cause mortality, ischemic stroke, peripheral arterial disease, congestive heart failure, and recurrence of ischemic events. After reviewing the information with respect to major aspects of cardiovascular pathophysiology, to potential confounders and to underlying mechanisms, several concepts emerge. First, the recommended amounts of "safe alcohol drinking" in healthy individuals are up to two standard drinks (~20 g/d) for a man and up to one drink (10 g/d) for a nonpregnant woman. The overall balance for young premenopausal women, but not for older women, would be unfavorable for drinking. The risk of cancer would not outweigh potential benefits of alcohol on heart disease. Second, within the frame of a balanced pattern of dietary energy intake, patients with cardiovascular disease who drink alcohol should not exceed one or two standard drinks per day for women or up to two or three drinks per day for men. Third, the low rates of coronary heart disease among the Mediterranean people may be related to their pattern of drinking wine every day during meals. Regular drinking is associated with better outcomes than occasional (binge)/weekly drinking. Fourth, wine (ethanol with antioxidants) exhibits significantly higher anti-inflammatory effects than gin (ethanol without polyphenols), and thus in general wine should be preferred to liquor or beer. SN - 1098-9064 UR - https://www.unboundmedicine.com/medline/citation/22198852/Alcohol_dosing_and_the_heart:_updating_clinical_evidence_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0031-1297366 DB - PRIME DP - Unbound Medicine ER -