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Facial emotion triggered cerebral potentials in treatment-resistant depression and borderline personality disorder patients of both genders.
Prog Neuropsychopharmacol Biol Psychiatry. 2012 Apr 27; 37(1):121-7.PN

Abstract

BACKGROUND

Processing facial expressions of emotion is deteriorated in depression, which might be more pronounced in treatment-resistant depression (TRD), especially when the latter is comorbid with borderline personality disorder (BPD). Neurophysiologically, both early perceptual and late cognitive cerebral processes of facial emotions can be illustrated by event-related potentials (ERPs).

METHODS

We therefore tried the ERPs to facial expressions of Neutral, Anger, Happiness, and Sadness in 25 patients with TRD, 15 with BPD, 22 with their comorbidity (TRD+BPD), as well as in 37 healthy volunteers. The depression levels of participants were measured with the Plutchik-van Praag Depressive Inventory (PVP).

RESULTS

There was no group difference regarding either N1 (N170), P2, N2, P3a or P3b latency or amplitude to the four facial emotions. Reaction times (RTs) to Anger (p<.01), Happiness (p<.01), and Sadness (p<.001) in TRD, and those to Anger (p<.01) and Happiness (p<.01) in TRD+BPD patients were longer than those in the healthy volunteers. RTs to the four facial expressions were positively correlated (p<.01) with their depressive moods in all participants. In addition, PVP was positively correlated with the P2 latency to Anger in TRD+BPD patients (Fz, p<.01; Cz, p<.01; Pz, p<.01).

CONCLUSIONS

BPD contributed little to TRD or TRD+BPD regarding cerebral processing of facial emotions, however, other cognitive and behavioral data suggest a generalized impairment when responding to facial emotions in TRD and TRD+BPD patients, and a deteriorated perceptual processing of Anger in TRD+BPD patients.

Authors+Show Affiliations

Department of Clinical Psychology and Psychiatry, Zhejiang University School of Medicine, Hangzhou, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22200559

Citation

He, Wei, et al. "Facial Emotion Triggered Cerebral Potentials in Treatment-resistant Depression and Borderline Personality Disorder Patients of Both Genders." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 37, no. 1, 2012, pp. 121-7.
He W, Chai H, Chen W, et al. Facial emotion triggered cerebral potentials in treatment-resistant depression and borderline personality disorder patients of both genders. Prog Neuropsychopharmacol Biol Psychiatry. 2012;37(1):121-7.
He, W., Chai, H., Chen, W., Zhang, J., Xu, Y., Zhu, J., & Wang, W. (2012). Facial emotion triggered cerebral potentials in treatment-resistant depression and borderline personality disorder patients of both genders. Progress in Neuro-psychopharmacology & Biological Psychiatry, 37(1), 121-7. https://doi.org/10.1016/j.pnpbp.2011.12.003
He W, et al. Facial Emotion Triggered Cerebral Potentials in Treatment-resistant Depression and Borderline Personality Disorder Patients of Both Genders. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Apr 27;37(1):121-7. PubMed PMID: 22200559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Facial emotion triggered cerebral potentials in treatment-resistant depression and borderline personality disorder patients of both genders. AU - He,Wei, AU - Chai,Hao, AU - Chen,Wanzhen, AU - Zhang,Jinhua, AU - Xu,You, AU - Zhu,Junpeng, AU - Wang,Wei, Y1 - 2011/12/19/ PY - 2011/10/17/received PY - 2011/12/05/revised PY - 2011/12/09/accepted PY - 2011/12/28/entrez PY - 2011/12/28/pubmed PY - 2012/11/9/medline SP - 121 EP - 7 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 37 IS - 1 N2 - BACKGROUND: Processing facial expressions of emotion is deteriorated in depression, which might be more pronounced in treatment-resistant depression (TRD), especially when the latter is comorbid with borderline personality disorder (BPD). Neurophysiologically, both early perceptual and late cognitive cerebral processes of facial emotions can be illustrated by event-related potentials (ERPs). METHODS: We therefore tried the ERPs to facial expressions of Neutral, Anger, Happiness, and Sadness in 25 patients with TRD, 15 with BPD, 22 with their comorbidity (TRD+BPD), as well as in 37 healthy volunteers. The depression levels of participants were measured with the Plutchik-van Praag Depressive Inventory (PVP). RESULTS: There was no group difference regarding either N1 (N170), P2, N2, P3a or P3b latency or amplitude to the four facial emotions. Reaction times (RTs) to Anger (p<.01), Happiness (p<.01), and Sadness (p<.001) in TRD, and those to Anger (p<.01) and Happiness (p<.01) in TRD+BPD patients were longer than those in the healthy volunteers. RTs to the four facial expressions were positively correlated (p<.01) with their depressive moods in all participants. In addition, PVP was positively correlated with the P2 latency to Anger in TRD+BPD patients (Fz, p<.01; Cz, p<.01; Pz, p<.01). CONCLUSIONS: BPD contributed little to TRD or TRD+BPD regarding cerebral processing of facial emotions, however, other cognitive and behavioral data suggest a generalized impairment when responding to facial emotions in TRD and TRD+BPD patients, and a deteriorated perceptual processing of Anger in TRD+BPD patients. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/22200559/Facial_emotion_triggered_cerebral_potentials_in_treatment_resistant_depression_and_borderline_personality_disorder_patients_of_both_genders_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(11)00353-8 DB - PRIME DP - Unbound Medicine ER -