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Molecular mechanisms of the neuroprotective/neurorescue action of multi-target green tea polyphenols.
Front Biosci (Schol Ed). 2012 01 01; 4(2):581-98.FB

Abstract

Mounting evidence suggests that lifestyle factors, especially nutrition are essential factor for healthy ageing. However, as a result of the increase in life expectance, neurodegenerative diseases like Alzheimer's and Parkinson's (AD and PD, respectively) are becoming an increasing burden, as aging is their main risk factor. Brain aging and neurodegenerative diseases of the elderly are characterized by oxidative damage, dysregulation of redox metals homeostasis and inflammation. Thus, it is not surprising that a large amount of drugs/agents in therapeutic use for these conditions are antioxidants/metal complexing, bioenergetic and anti-inflammatory agents. Natural plant polyphenols (flavonoids and non-flavonoids) are the most abundant antioxidants in the diet and as such, are ideal nutraceuticals for neutralizing stress-induced free radicals and inflammation. Human epidemiological and new animal data suggest that green and black flavonoids named catechins, may help protecting the aging brain and reduce the incidence of dementia, AD and PD. This review will present salient features of the beneficial multi-pharmacological actions of black and green tea polyphenols in aging and neurodegeneration, and speculate on their potential in drug combination to target distinct pathologies as a therapeutic disease modification approach.

Authors+Show Affiliations

Eve Topf Center for Neurodegenerative Diseases Research and Department of Molecular Pharmacology, Faculty of Medicine, Technion, Haifa, Israel. mandel@tx.technion.ac.ilNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22202078

Citation

Mandel, Silvia A., et al. "Molecular Mechanisms of the Neuroprotective/neurorescue Action of Multi-target Green Tea Polyphenols." Frontiers in Bioscience (Scholar Edition), vol. 4, no. 2, 2012, pp. 581-98.
Mandel SA, Weinreb O, Amit T, et al. Molecular mechanisms of the neuroprotective/neurorescue action of multi-target green tea polyphenols. Front Biosci (Schol Ed). 2012;4(2):581-98.
Mandel, S. A., Weinreb, O., Amit, T., & Youdim, M. B. (2012). Molecular mechanisms of the neuroprotective/neurorescue action of multi-target green tea polyphenols. Frontiers in Bioscience (Scholar Edition), 4(2), 581-98.
Mandel SA, et al. Molecular Mechanisms of the Neuroprotective/neurorescue Action of Multi-target Green Tea Polyphenols. Front Biosci (Schol Ed). 2012 01 1;4(2):581-98. PubMed PMID: 22202078.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular mechanisms of the neuroprotective/neurorescue action of multi-target green tea polyphenols. AU - Mandel,Silvia A, AU - Weinreb,Orly, AU - Amit,Tamar, AU - Youdim,Moussa B H, Y1 - 2012/01/01/ PY - 2011/12/29/entrez PY - 2011/12/29/pubmed PY - 2013/8/6/medline SP - 581 EP - 98 JF - Frontiers in bioscience (Scholar edition) JO - Front Biosci (Schol Ed) VL - 4 IS - 2 N2 - Mounting evidence suggests that lifestyle factors, especially nutrition are essential factor for healthy ageing. However, as a result of the increase in life expectance, neurodegenerative diseases like Alzheimer's and Parkinson's (AD and PD, respectively) are becoming an increasing burden, as aging is their main risk factor. Brain aging and neurodegenerative diseases of the elderly are characterized by oxidative damage, dysregulation of redox metals homeostasis and inflammation. Thus, it is not surprising that a large amount of drugs/agents in therapeutic use for these conditions are antioxidants/metal complexing, bioenergetic and anti-inflammatory agents. Natural plant polyphenols (flavonoids and non-flavonoids) are the most abundant antioxidants in the diet and as such, are ideal nutraceuticals for neutralizing stress-induced free radicals and inflammation. Human epidemiological and new animal data suggest that green and black flavonoids named catechins, may help protecting the aging brain and reduce the incidence of dementia, AD and PD. This review will present salient features of the beneficial multi-pharmacological actions of black and green tea polyphenols in aging and neurodegeneration, and speculate on their potential in drug combination to target distinct pathologies as a therapeutic disease modification approach. SN - 1945-0524 UR - https://www.unboundmedicine.com/medline/citation/22202078/Molecular_mechanisms_of_the_neuroprotective/neurorescue_action_of_multi_target_green_tea_polyphenols_ L2 - https://www.imrpress.com/journal/FBS/4/2/10.2741/S286 DB - PRIME DP - Unbound Medicine ER -