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Evaluation of prevalence of low and high level mupirocin resistance in methicillin resistant Staphylococcus aureus isolates at a tertiary care hospital.

Abstract

OBJECTIVE

To evaluate the trend of mupirocin resistance in MRSA, isolated at the Clinical Microbiology Laboratory of a tertiary care hospital.

METHODS

A total of 200 MRSA strains recovered over a 2 year period from various body sites were tested using the 5 and 200 microg discs of mupirocin to detect its resistance.

RESULTS

High level and low level mupirocin resistance were detected in zero and 1% of MRSA strains, respectively. Resistance to other non beta lactam antibiotics was also high. No MRSA strains were found to be resistant to vancomycin and tegicycline.

CONCLUSION

Mupirocin resistance was found to be very low among local clinical isolates of MRSA. Its judicious use to decolonize nasal carriers should be promoted among hospitalized patients to avoid further transmission and infections due to prevalent endemic MRSA strains in any health care setting. Concomitantly, regular surveillance and effective infection control initiatives are desirable to reduce the incidence of health care associated infections due to MRSA and also of mupirocin resistance.

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    MeSH

    Anti-Bacterial Agents
    Drug Resistance, Bacterial
    Hospitals, Teaching
    Humans
    Methicillin-Resistant Staphylococcus aureus
    Microbial Sensitivity Tests
    Mupirocin
    Pakistan
    Prevalence
    Staphylococcal Infections

    Pub Type(s)

    Evaluation Studies
    Journal Article

    Language

    eng

    PubMed ID

    22204200

    Citation

    TY - JOUR T1 - Evaluation of prevalence of low and high level mupirocin resistance in methicillin resistant Staphylococcus aureus isolates at a tertiary care hospital. AU - Nizamuddin,Summiya, AU - Irfan,Seema, AU - Zafar,Afia, PY - 2011/12/30/entrez PY - 2011/12/30/pubmed PY - 2012/2/2/medline SP - 519 EP - 21 JF - JPMA. The Journal of the Pakistan Medical Association JO - J Pak Med Assoc VL - 61 IS - 6 N2 - OBJECTIVE: To evaluate the trend of mupirocin resistance in MRSA, isolated at the Clinical Microbiology Laboratory of a tertiary care hospital. METHODS: A total of 200 MRSA strains recovered over a 2 year period from various body sites were tested using the 5 and 200 microg discs of mupirocin to detect its resistance. RESULTS: High level and low level mupirocin resistance were detected in zero and 1% of MRSA strains, respectively. Resistance to other non beta lactam antibiotics was also high. No MRSA strains were found to be resistant to vancomycin and tegicycline. CONCLUSION: Mupirocin resistance was found to be very low among local clinical isolates of MRSA. Its judicious use to decolonize nasal carriers should be promoted among hospitalized patients to avoid further transmission and infections due to prevalent endemic MRSA strains in any health care setting. Concomitantly, regular surveillance and effective infection control initiatives are desirable to reduce the incidence of health care associated infections due to MRSA and also of mupirocin resistance. SN - 0030-9982 UR - https://www.unboundmedicine.com/medline/citation/22204200/full_citation/Evaluation_of_prevalence_of_low_and_high_level_mupirocin_resistance_in_methicillin_resistant_Staphylococcus_aureus_isolates_at_a_tertiary_care_hospital_ L2 - http://www.nlm.nih.gov/medlineplus/antibiotics.html ER -