Tags

Type your tag names separated by a space and hit enter

Polysaccharide-K (PSK) in cancer--old story, new possibilities?
Curr Med Chem. 2012; 19(5):757-62.CM

Abstract

Polysaccharide-K (PSK, Krestin) is one of the most commonly used medicinal mushroom extracts with a long history as an additive in cancer therapy in Asia, especially in Japan. PSK has a documented anti-tumor activity both in vitro and in vitro, in various types of cancers, including colorectal, gastric, breast, liver, pancreatic, and lung cancer. Despite PSK having been studied for about 40 years as an immune modulator and biological response modifier, the mechanisms of action by PSK have not yet been clearly and completely elucidated. This review aims to provide an up-to-date account for the effects of PSK in cancer with the hope of thereby providing an increased understanding of the molecular mechanisms of PSK and also its potential as an additive in modern cancer therapy.

Authors+Show Affiliations

Sun C
Clinical Sciences Lund, Department of Surgery, Lund University, Lund, Sweden.
Rosendahl AH
No affiliation info available
Wang XD
No affiliation info available
Wu DQ
No affiliation info available
Andersson R
No affiliation info available

MeSH

AgaricalesAntineoplastic AgentsHumansNeoplasmsPlant ExtractsProteoglycans

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22204346

Citation

Sun, C, et al. "Polysaccharide-K (PSK) in Cancer--old Story, New Possibilities?" Current Medicinal Chemistry, vol. 19, no. 5, 2012, pp. 757-62.
Sun C, Rosendahl AH, Wang XD, et al. Polysaccharide-K (PSK) in cancer--old story, new possibilities? Curr Med Chem. 2012;19(5):757-62.
Sun, C., Rosendahl, A. H., Wang, X. D., Wu, D. Q., & Andersson, R. (2012). Polysaccharide-K (PSK) in cancer--old story, new possibilities? Current Medicinal Chemistry, 19(5), 757-62.
Sun C, et al. Polysaccharide-K (PSK) in Cancer--old Story, New Possibilities. Curr Med Chem. 2012;19(5):757-62. PubMed PMID: 22204346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polysaccharide-K (PSK) in cancer--old story, new possibilities? AU - Sun,C, AU - Rosendahl,A H, AU - Wang,X D, AU - Wu,D Q, AU - Andersson,R, PY - 2011/09/09/received PY - 2011/12/01/accepted PY - 2011/12/30/entrez PY - 2011/12/30/pubmed PY - 2012/7/24/medline SP - 757 EP - 62 JF - Current medicinal chemistry JO - Curr Med Chem VL - 19 IS - 5 N2 - Polysaccharide-K (PSK, Krestin) is one of the most commonly used medicinal mushroom extracts with a long history as an additive in cancer therapy in Asia, especially in Japan. PSK has a documented anti-tumor activity both in vitro and in vitro, in various types of cancers, including colorectal, gastric, breast, liver, pancreatic, and lung cancer. Despite PSK having been studied for about 40 years as an immune modulator and biological response modifier, the mechanisms of action by PSK have not yet been clearly and completely elucidated. This review aims to provide an up-to-date account for the effects of PSK in cancer with the hope of thereby providing an increased understanding of the molecular mechanisms of PSK and also its potential as an additive in modern cancer therapy. SN - 1875-533X UR - https://www.unboundmedicine.com/medline/citation/22204346/Polysaccharide_K__PSK__in_cancer__old_story_new_possibilities DB - PRIME DP - Unbound Medicine ER -