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Dietary magnesium intake and risk of stroke: a meta-analysis of prospective studies.
Am J Clin Nutr 2012; 95(2):362-6AJ

Abstract

BACKGROUND

Prospective studies of dietary magnesium intake in relation to risk of stroke have yielded inconsistent results.

OBJECTIVE

We conducted a dose-response meta-analysis to summarize the evidence regarding the association between magnesium intake and stroke risk.

DESIGN

Relevant studies were identified by searching PubMed and EMBASE from January 1966 through September 2011 and reviewing reference lists of retrieved articles. We included prospective studies that reported RRs with 95% CIs of stroke for ≥3 categories of magnesium intake. Results from individual studies were combined by using a random-effects model.

RESULTS

Seven prospective studies, with 6477 cases of stroke and 241,378 participants, were eligible for inclusion in the meta-analysis. We observed a modest but statistically significant inverse association between magnesium intake and risk of stroke. An intake increment of 100 mg Mg/d was associated with an 8% reduction in risk of total stroke (combined RR: 0.92; 95% CI: 0.88, 0.97), without heterogeneity among studies (P = 0.66, I(2) = 0%). Magnesium intake was inversely associated with risk of ischemic stroke (RR: 0.91; 95% CI: 0.87, 0.96) but not intracerebral hemorrhage (RR: 0.96; 95% CI: 0.84, 1.10) or subarachnoid hemorrhage (RR: 1.01; 95% CI: 0.90, 1.14).

CONCLUSION

Dietary magnesium intake is inversely associated with risk of stroke, specifically ischemic stroke.

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  • Publisher Full Text

    • Authors+Show Affiliations

    Larsson SC
    Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Stockholm, Sweden. susanna.larsson@ki.se
    Orsini N
    No affiliation info available
    Wolk A
    No affiliation info available

    MeSH

    Brain IschemiaCerebral HemorrhageDose-Response Relationship, DrugHumansMagnesiumProspective StudiesRisk FactorsStrokeSubarachnoid HemorrhageTrace Elements

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22205313

    Citation

    Larsson, Susanna C., et al. "Dietary Magnesium Intake and Risk of Stroke: a Meta-analysis of Prospective Studies." The American Journal of Clinical Nutrition, vol. 95, no. 2, 2012, pp. 362-6.
    Larsson SC, Orsini N, Wolk A. Dietary magnesium intake and risk of stroke: a meta-analysis of prospective studies. Am J Clin Nutr. 2012;95(2):362-6.
    Larsson, S. C., Orsini, N., & Wolk, A. (2012). Dietary magnesium intake and risk of stroke: a meta-analysis of prospective studies. The American Journal of Clinical Nutrition, 95(2), pp. 362-6. doi:10.3945/ajcn.111.022376.
    Larsson SC, Orsini N, Wolk A. Dietary Magnesium Intake and Risk of Stroke: a Meta-analysis of Prospective Studies. Am J Clin Nutr. 2012;95(2):362-6. PubMed PMID: 22205313.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary magnesium intake and risk of stroke: a meta-analysis of prospective studies. AU - Larsson,Susanna C, AU - Orsini,Nicola, AU - Wolk,Alicja, Y1 - 2011/12/28/ PY - 2011/12/30/entrez PY - 2011/12/30/pubmed PY - 2012/3/7/medline SP - 362 EP - 6 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 95 IS - 2 N2 - BACKGROUND: Prospective studies of dietary magnesium intake in relation to risk of stroke have yielded inconsistent results. OBJECTIVE: We conducted a dose-response meta-analysis to summarize the evidence regarding the association between magnesium intake and stroke risk. DESIGN: Relevant studies were identified by searching PubMed and EMBASE from January 1966 through September 2011 and reviewing reference lists of retrieved articles. We included prospective studies that reported RRs with 95% CIs of stroke for ≥3 categories of magnesium intake. Results from individual studies were combined by using a random-effects model. RESULTS: Seven prospective studies, with 6477 cases of stroke and 241,378 participants, were eligible for inclusion in the meta-analysis. We observed a modest but statistically significant inverse association between magnesium intake and risk of stroke. An intake increment of 100 mg Mg/d was associated with an 8% reduction in risk of total stroke (combined RR: 0.92; 95% CI: 0.88, 0.97), without heterogeneity among studies (P = 0.66, I(2) = 0%). Magnesium intake was inversely associated with risk of ischemic stroke (RR: 0.91; 95% CI: 0.87, 0.96) but not intracerebral hemorrhage (RR: 0.96; 95% CI: 0.84, 1.10) or subarachnoid hemorrhage (RR: 1.01; 95% CI: 0.90, 1.14). CONCLUSION: Dietary magnesium intake is inversely associated with risk of stroke, specifically ischemic stroke. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22205313/Dietary_magnesium_intake_and_risk_of_stroke:_a_meta_analysis_of_prospective_studies_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.022376 DB - PRIME DP - Unbound Medicine ER -