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Two randomized, controlled, comparative studies of the stratum corneum integrity benefits of two cosmetic niacinamide/glycerin body moisturizers vs. conventional body moisturizers.
J Drugs Dermatol. 2012 Jan; 11(1):22-9.JD

Abstract

BACKGROUND AND OBJECTIVE

Despite numerous body moisturizers being available, cosmetic xerosis continues to be a leading skin problem for consumers. We performed two 35-day studies to evaluate the ability of a variety of body moisturizers containing various levels of oils/lipids, humectants, as well as other ingredients (e.g., niacinamide) to improve stratum corneum integrity.

METHODS

63 and 58 female subjects were enrolled and randomized in an incomplete block design to six of nine products (eight moisturizers or no treatment control) in studies 1 and 2, respectively. The primary endpoints included visual dryness by a qualified skin grader, skin hydration as measured by Corneometer, and barrier integrity as measured by transepidermal water loss (TEWL). The primary comparisons for the two niacinamide/glycerin moisturizers were to the other six moisturizers and to the no treatment control for each endpoint.

RESULTS

The two niacinamide/glycerin moisturizers demonstrated an overall better solution towards rapid and prolonged improvement of cosmetic xerosis due to functional improvement of stratum corneum barrier function compared to no treatment and the other moisturizers tested.

CONCLUSIONS

These studies establish the benefit of including niacinamide in a body moisturizer to improve the integrity of the stratum corneum and thus reduce cosmetic xerosis over time.

Authors+Show Affiliations

Christman JC
The Procter & Gamble Company, Cincinnati, OH 45217, USA. christman.jc@pg.com
Fix DK
No affiliation info available
Lucus SC
No affiliation info available
Watson D
No affiliation info available
Desmier E
No affiliation info available
Wilkerson RJ
No affiliation info available
Fixler C
No affiliation info available

MeSH

Administration, TopicalAdolescentAdultAgedChemistry, PharmaceuticalCosmeticsDouble-Blind MethodDrug CombinationsEmollientsEpidermisFemaleGlycerolHumansMiddle AgedNiacinamideYoung Adult

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

22206073

Citation

Christman, Jeremy C., et al. "Two Randomized, Controlled, Comparative Studies of the Stratum Corneum Integrity Benefits of Two Cosmetic Niacinamide/glycerin Body Moisturizers Vs. Conventional Body Moisturizers." Journal of Drugs in Dermatology : JDD, vol. 11, no. 1, 2012, pp. 22-9.
Christman JC, Fix DK, Lucus SC, et al. Two randomized, controlled, comparative studies of the stratum corneum integrity benefits of two cosmetic niacinamide/glycerin body moisturizers vs. conventional body moisturizers. J Drugs Dermatol. 2012;11(1):22-9.
Christman, J. C., Fix, D. K., Lucus, S. C., Watson, D., Desmier, E., Wilkerson, R. J., & Fixler, C. (2012). Two randomized, controlled, comparative studies of the stratum corneum integrity benefits of two cosmetic niacinamide/glycerin body moisturizers vs. conventional body moisturizers. Journal of Drugs in Dermatology : JDD, 11(1), 22-9.
Christman JC, et al. Two Randomized, Controlled, Comparative Studies of the Stratum Corneum Integrity Benefits of Two Cosmetic Niacinamide/glycerin Body Moisturizers Vs. Conventional Body Moisturizers. J Drugs Dermatol. 2012;11(1):22-9. PubMed PMID: 22206073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two randomized, controlled, comparative studies of the stratum corneum integrity benefits of two cosmetic niacinamide/glycerin body moisturizers vs. conventional body moisturizers. AU - Christman,Jeremy C, AU - Fix,Deborah K, AU - Lucus,Sawanna C, AU - Watson,Debrah, AU - Desmier,Emma, AU - Wilkerson,Rolanda J Johnson, AU - Fixler,Charles, PY - 2011/12/30/entrez PY - 2011/12/30/pubmed PY - 2012/6/9/medline SP - 22 EP - 9 JF - Journal of drugs in dermatology : JDD JO - J Drugs Dermatol VL - 11 IS - 1 N2 - BACKGROUND AND OBJECTIVE: Despite numerous body moisturizers being available, cosmetic xerosis continues to be a leading skin problem for consumers. We performed two 35-day studies to evaluate the ability of a variety of body moisturizers containing various levels of oils/lipids, humectants, as well as other ingredients (e.g., niacinamide) to improve stratum corneum integrity. METHODS: 63 and 58 female subjects were enrolled and randomized in an incomplete block design to six of nine products (eight moisturizers or no treatment control) in studies 1 and 2, respectively. The primary endpoints included visual dryness by a qualified skin grader, skin hydration as measured by Corneometer, and barrier integrity as measured by transepidermal water loss (TEWL). The primary comparisons for the two niacinamide/glycerin moisturizers were to the other six moisturizers and to the no treatment control for each endpoint. RESULTS: The two niacinamide/glycerin moisturizers demonstrated an overall better solution towards rapid and prolonged improvement of cosmetic xerosis due to functional improvement of stratum corneum barrier function compared to no treatment and the other moisturizers tested. CONCLUSIONS: These studies establish the benefit of including niacinamide in a body moisturizer to improve the integrity of the stratum corneum and thus reduce cosmetic xerosis over time. SN - 1545-9616 UR - https://www.unboundmedicine.com/medline/citation/22206073/Two_randomized_controlled_comparative_studies_of_the_stratum_corneum_integrity_benefits_of_two_cosmetic_niacinamide/glycerin_body_moisturizers_vs__conventional_body_moisturizers_ DB - PRIME DP - Unbound Medicine ER -