Tags

Type your tag names separated by a space and hit enter

Zinc, ferritin, magnesium and copper in a group of Egyptian children with attention deficit hyperactivity disorder.

Abstract

BACKGROUND

Attention deficit hyperactivity disorder is a behavioral syndrome of childhood characterized by inattention, hyperactivity and impulsivity. There were many etiological theories showed dysfunction of some brain areas that are implicated in inhibition of responses and functions of the brain. Minerals like zinc, ferritin, magnesium and copper may play a role in the pathogenesis and therefore the treatment of this disorder.

OBJECTIVE

This study aimed to measure levels of zinc, ferritin, magnesium and copper in children with attention deficit hyperactivity disorder and comparing them to normal.

METHODS

This study included 58 children aged 5-15 years with attention deficit hyperactivity disorder attending Minia University Hospital from June 2008 to January 2010. They were classified into three sub-groups: sub-group I included 32 children with in-attentive type, sub-group II included 10 children with hyperactive type and sub-group III included 16 children with combined type according to the DSM-IV criteria of American Psychiatric Association, 2000. The control group included 25 apparently normal healthy children.

RESULTS

Zinc, ferritin and magnesium levels were significantly lower in children with attention deficit hyperactivity disorder than controls (p value 0.04, 0.03 and 0.02 respectively), while copper levels were not significantly different (p value 0.9). Children with inattentive type had significant lower levels of zinc and ferritin than controls (p value 0.001 and 0.01 respectively) with no significant difference between them as regards magnesium and copper levels (p value 0.4 and 0.6 respectively). Children with hyperactive type had significant lower levels of zinc, ferritin and magnesium than controls (p value 0.01, 0.02 and 0.02 respectively) with no significant difference between them as regards copper levels (p value 0.9). Children with combined type had significant lower levels of zinc and magnesium than controls (p value 0.001 and 0.004 respectively) with no significant difference between them as regards ferritin and copper levels (p value 0.7 and 0.6 respectively).

CONCLUSIONS

Children with attention deficit hyperactivity disorder had lower levels of zinc, ferritin and magnesium than healthy children but had normal copper levels.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Pediatric Department, Minia University, Minia, Egypt.

    , ,

    Source

    Italian journal of pediatrics 37: 2011 Dec 29 pg 60

    MeSH

    Adolescent
    Attention Deficit Disorder with Hyperactivity
    Biomarkers
    Child
    Child, Preschool
    Copper
    Egypt
    Female
    Ferritins
    Humans
    Magnesium
    Male
    Prevalence
    Prognosis
    Retrospective Studies
    Zinc

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22206662

    Citation

    Mahmoud, Magdy M., et al. "Zinc, Ferritin, Magnesium and Copper in a Group of Egyptian Children With Attention Deficit Hyperactivity Disorder." Italian Journal of Pediatrics, vol. 37, 2011, p. 60.
    Mahmoud MM, El-Mazary AA, Maher RM, et al. Zinc, ferritin, magnesium and copper in a group of Egyptian children with attention deficit hyperactivity disorder. Ital J Pediatr. 2011;37:60.
    Mahmoud, M. M., El-Mazary, A. A., Maher, R. M., & Saber, M. M. (2011). Zinc, ferritin, magnesium and copper in a group of Egyptian children with attention deficit hyperactivity disorder. Italian Journal of Pediatrics, 37, p. 60. doi:10.1186/1824-7288-37-60.
    Mahmoud MM, et al. Zinc, Ferritin, Magnesium and Copper in a Group of Egyptian Children With Attention Deficit Hyperactivity Disorder. Ital J Pediatr. 2011 Dec 29;37:60. PubMed PMID: 22206662.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Zinc, ferritin, magnesium and copper in a group of Egyptian children with attention deficit hyperactivity disorder. AU - Mahmoud,Magdy M, AU - El-Mazary,Abdel-Azeem M, AU - Maher,Reham M, AU - Saber,Manal M, Y1 - 2011/12/29/ PY - 2011/04/10/received PY - 2011/12/29/accepted PY - 2011/12/31/entrez PY - 2011/12/31/pubmed PY - 2012/6/6/medline SP - 60 EP - 60 JF - Italian journal of pediatrics JO - Ital J Pediatr VL - 37 N2 - BACKGROUND: Attention deficit hyperactivity disorder is a behavioral syndrome of childhood characterized by inattention, hyperactivity and impulsivity. There were many etiological theories showed dysfunction of some brain areas that are implicated in inhibition of responses and functions of the brain. Minerals like zinc, ferritin, magnesium and copper may play a role in the pathogenesis and therefore the treatment of this disorder. OBJECTIVE: This study aimed to measure levels of zinc, ferritin, magnesium and copper in children with attention deficit hyperactivity disorder and comparing them to normal. METHODS: This study included 58 children aged 5-15 years with attention deficit hyperactivity disorder attending Minia University Hospital from June 2008 to January 2010. They were classified into three sub-groups: sub-group I included 32 children with in-attentive type, sub-group II included 10 children with hyperactive type and sub-group III included 16 children with combined type according to the DSM-IV criteria of American Psychiatric Association, 2000. The control group included 25 apparently normal healthy children. RESULTS: Zinc, ferritin and magnesium levels were significantly lower in children with attention deficit hyperactivity disorder than controls (p value 0.04, 0.03 and 0.02 respectively), while copper levels were not significantly different (p value 0.9). Children with inattentive type had significant lower levels of zinc and ferritin than controls (p value 0.001 and 0.01 respectively) with no significant difference between them as regards magnesium and copper levels (p value 0.4 and 0.6 respectively). Children with hyperactive type had significant lower levels of zinc, ferritin and magnesium than controls (p value 0.01, 0.02 and 0.02 respectively) with no significant difference between them as regards copper levels (p value 0.9). Children with combined type had significant lower levels of zinc and magnesium than controls (p value 0.001 and 0.004 respectively) with no significant difference between them as regards ferritin and copper levels (p value 0.7 and 0.6 respectively). CONCLUSIONS: Children with attention deficit hyperactivity disorder had lower levels of zinc, ferritin and magnesium than healthy children but had normal copper levels. SN - 1824-7288 UR - https://www.unboundmedicine.com/medline/citation/22206662/Zinc_ferritin_magnesium_and_copper_in_a_group_of_Egyptian_children_with_attention_deficit_hyperactivity_disorder_ L2 - https://ijponline.biomedcentral.com/articles/10.1186/1824-7288-37-60 DB - PRIME DP - Unbound Medicine ER -