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Amyloidosis of seminal vesicles; incidence and pathologic characteristics.
Turk Patoloji Derg. 2012; 28(1):44-8.TP

Abstract

OBJECTIVE

Amyloidosis is a rare disease with various etiologies with extracellular amyloid protein depositions. At present, at least 26 distinctive amyloid forms have been detected with different clinical importance and treatment. They have characteristic staning fetaures with Congo red. Amyloid may be detected in 2-10% of prostates that have been removed because of hyperplasia or carcinoma. Amyloidosis of seminal vesicles is accepted as senil amyloidosis and it is not accompanied by systemic amyloidosis or clinical symptoms. This condition is the most common form of localized amyloidosis. In this study we aimed to investigate incidence and histologic characteristics of amyloidosis of seminal vesicles in radical prostatectomy materials of the patients whose prostate carcinomas were treated surgically.

MATERIAL AND METHOD

Amyloid depositions in seminal vesicles of 207 radical prostatectomy materials that prostates had been removed due to localized prostate carcinoma. Amyloid depositions were confirmed with Congo red staining and polarization microscope.

RESULTS

Amyloidosis of seminal vesicles was detected in 10 (4.8%) of cases. Mean age of the patients is 66.2 years. Amyloid depositions tend to be nodular and bilateral in subepithelial region of affected seminal vesicles. Amyloid depositions were not detected in blood vessels in seminal vesicles or prostate parenchyma.

CONCLUSION

Localized amyloidosis of seminal vesicles is not an unusual finding. amyloidosis of seminal vesicles incidence in Turkish patients included in this study and histopathologic characteristics of these patients are not different from the other studies. Systemic AA amyloidosis is the most common form of amyloidosis in our country. To be aware of amyloidosis of seminal vesicles is of importance in discrimination from the other forms of amyloidosis.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Argon A
Department of Pathology, Ege University, Faculty of Medicine, İzmir, Turkey.
Sımşır A
No affiliation info available
Sarsik B
No affiliation info available
Tuna B
No affiliation info available
Yörükoğlu K
No affiliation info available
Nıflıoğlu GG
No affiliation info available
Sen S
No affiliation info available

MeSH

AdenocarcinomaAgedAmyloidosisHumansIncidenceIncidental FindingsMaleProstatic NeoplasmsSeminal Vesicles

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22207431

Citation

Argon, Asuman, et al. "Amyloidosis of Seminal Vesicles; Incidence and Pathologic Characteristics." Turk Patoloji Dergisi, vol. 28, no. 1, 2012, pp. 44-8.
Argon A, Sımşır A, Sarsik B, et al. Amyloidosis of seminal vesicles; incidence and pathologic characteristics. Turk Patoloji Derg. 2012;28(1):44-8.
Argon, A., Sımşır, A., Sarsik, B., Tuna, B., Yörükoğlu, K., Nıflıoğlu, G. G., & Sen, S. (2012). Amyloidosis of seminal vesicles; incidence and pathologic characteristics. Turk Patoloji Dergisi, 28(1), 44-8. https://doi.org/10.5146/tjpath.2012.01096
Argon A, et al. Amyloidosis of Seminal Vesicles; Incidence and Pathologic Characteristics. Turk Patoloji Derg. 2012;28(1):44-8. PubMed PMID: 22207431.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amyloidosis of seminal vesicles; incidence and pathologic characteristics. AU - Argon,Asuman, AU - Sımşır,Adnan, AU - Sarsik,Banu, AU - Tuna,Burçin, AU - Yörükoğlu,Kutsal, AU - Nıflıoğlu,Gülen Gül, AU - Sen,Sait, PY - 2011/12/31/entrez PY - 2011/12/31/pubmed PY - 2012/4/28/medline SP - 44 EP - 8 JF - Turk patoloji dergisi JO - Turk Patoloji Derg VL - 28 IS - 1 N2 - OBJECTIVE: Amyloidosis is a rare disease with various etiologies with extracellular amyloid protein depositions. At present, at least 26 distinctive amyloid forms have been detected with different clinical importance and treatment. They have characteristic staning fetaures with Congo red. Amyloid may be detected in 2-10% of prostates that have been removed because of hyperplasia or carcinoma. Amyloidosis of seminal vesicles is accepted as senil amyloidosis and it is not accompanied by systemic amyloidosis or clinical symptoms. This condition is the most common form of localized amyloidosis. In this study we aimed to investigate incidence and histologic characteristics of amyloidosis of seminal vesicles in radical prostatectomy materials of the patients whose prostate carcinomas were treated surgically. MATERIAL AND METHOD: Amyloid depositions in seminal vesicles of 207 radical prostatectomy materials that prostates had been removed due to localized prostate carcinoma. Amyloid depositions were confirmed with Congo red staining and polarization microscope. RESULTS: Amyloidosis of seminal vesicles was detected in 10 (4.8%) of cases. Mean age of the patients is 66.2 years. Amyloid depositions tend to be nodular and bilateral in subepithelial region of affected seminal vesicles. Amyloid depositions were not detected in blood vessels in seminal vesicles or prostate parenchyma. CONCLUSION: Localized amyloidosis of seminal vesicles is not an unusual finding. amyloidosis of seminal vesicles incidence in Turkish patients included in this study and histopathologic characteristics of these patients are not different from the other studies. Systemic AA amyloidosis is the most common form of amyloidosis in our country. To be aware of amyloidosis of seminal vesicles is of importance in discrimination from the other forms of amyloidosis. SN - 1309-5730 UR - https://www.unboundmedicine.com/medline/citation/22207431/Amyloidosis_of_seminal_vesicles L2 - http://dx.doi.org/10.5146/tjpath.2012.01096 DB - PRIME DP - Unbound Medicine ER -