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Enantiomeric profiling of chiral drugs in wastewater and receiving waters.
Environ Sci Technol. 2012 Feb 07; 46(3):1681-91.ES

Abstract

The aim of this paper is to discuss the enantiomer-specific fate of chiral drugs during wastewater treatment and in receiving waters. Several chiral drugs were studied: amphetamine-like drugs of abuse (amphetamine, methamphetamine, MDMA, MDA), ephedrines (ephedrine and pseudoephedrine), antidepressant venlafaxine, and beta-blocker atenolol. A monitoring program was undertaken in 7 WWTPs (utilizing mainly activated sludge and trickling filters technologies) and at 6 sampling points in receiving waters over the period of 9 months. The results revealed the enantiomer-specific fate of all studied drugs during both wastewater treatment and in the aqueous environment. The extent of stereoselectivity depended on several parameters including: type of chiral drug (high stereoselectivity was recorded for atenolol and MDMA), treatment technology used (activated sludge showed higher stereoselectivity than trickling filters), and season (higher stereoselectivity was observed in the aqueous environment over the spring/summer time).

Authors+Show Affiliations

Department of Chemistry, Faculty of Science, University of Bath, Bath BA2 7AY, U.K. b.kasprzyk-hordern@bath.ac.ukNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22208427

Citation

Kasprzyk-Hordern, Barbara, and David R. Baker. "Enantiomeric Profiling of Chiral Drugs in Wastewater and Receiving Waters." Environmental Science & Technology, vol. 46, no. 3, 2012, pp. 1681-91.
Kasprzyk-Hordern B, Baker DR. Enantiomeric profiling of chiral drugs in wastewater and receiving waters. Environ Sci Technol. 2012;46(3):1681-91.
Kasprzyk-Hordern, B., & Baker, D. R. (2012). Enantiomeric profiling of chiral drugs in wastewater and receiving waters. Environmental Science & Technology, 46(3), 1681-91. https://doi.org/10.1021/es203113y
Kasprzyk-Hordern B, Baker DR. Enantiomeric Profiling of Chiral Drugs in Wastewater and Receiving Waters. Environ Sci Technol. 2012 Feb 7;46(3):1681-91. PubMed PMID: 22208427.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enantiomeric profiling of chiral drugs in wastewater and receiving waters. AU - Kasprzyk-Hordern,Barbara, AU - Baker,David R, Y1 - 2012/01/18/ PY - 2012/1/3/entrez PY - 2012/1/3/pubmed PY - 2012/6/5/medline SP - 1681 EP - 91 JF - Environmental science & technology JO - Environ Sci Technol VL - 46 IS - 3 N2 - The aim of this paper is to discuss the enantiomer-specific fate of chiral drugs during wastewater treatment and in receiving waters. Several chiral drugs were studied: amphetamine-like drugs of abuse (amphetamine, methamphetamine, MDMA, MDA), ephedrines (ephedrine and pseudoephedrine), antidepressant venlafaxine, and beta-blocker atenolol. A monitoring program was undertaken in 7 WWTPs (utilizing mainly activated sludge and trickling filters technologies) and at 6 sampling points in receiving waters over the period of 9 months. The results revealed the enantiomer-specific fate of all studied drugs during both wastewater treatment and in the aqueous environment. The extent of stereoselectivity depended on several parameters including: type of chiral drug (high stereoselectivity was recorded for atenolol and MDMA), treatment technology used (activated sludge showed higher stereoselectivity than trickling filters), and season (higher stereoselectivity was observed in the aqueous environment over the spring/summer time). SN - 1520-5851 UR - https://www.unboundmedicine.com/medline/citation/22208427/Enantiomeric_profiling_of_chiral_drugs_in_wastewater_and_receiving_waters_ L2 - https://doi.org/10.1021/es203113y DB - PRIME DP - Unbound Medicine ER -