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Oral contraceptives and breast cancer.
Am J Obstet Gynecol 1990; 163(4 Pt 2):1379-87AJ

Abstract

Among women in general the risk of breast cancer through 59 years of age does not appear to be affected appreciably by the use of oral contraceptives. Nonetheless, concern continues to be expressed about the effects of early age at first use, long-term duration of use, formulation, and a variety of other factors thought to influence breast cancer risk in the presence of oral contraception. A number of recent studies restricted to young women suggest that long-term use may increase the risk of disease occurring very early, but the present lack of consistent findings in well-conducted epidemiologic studies prevents any certain conclusion with regard to cause-and-effect. However, if an increased risk were indeed present, the most plausible interpretation is that long-term oral contraception promotes earlier clinical manifestation of breast cancer in some women while having no net impact on their lifetime risk of the disease.

Authors+Show Affiliations

Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

2220962

Citation

Schlesselman, J J.. "Oral Contraceptives and Breast Cancer." American Journal of Obstetrics and Gynecology, vol. 163, no. 4 Pt 2, 1990, pp. 1379-87.
Schlesselman JJ. Oral contraceptives and breast cancer. Am J Obstet Gynecol. 1990;163(4 Pt 2):1379-87.
Schlesselman, J. J. (1990). Oral contraceptives and breast cancer. American Journal of Obstetrics and Gynecology, 163(4 Pt 2), pp. 1379-87.
Schlesselman JJ. Oral Contraceptives and Breast Cancer. Am J Obstet Gynecol. 1990;163(4 Pt 2):1379-87. PubMed PMID: 2220962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral contraceptives and breast cancer. A1 - Schlesselman,J J, PY - 1990/10/1/pubmed PY - 1990/10/1/medline PY - 1990/10/1/entrez KW - Age Factors KW - Biology KW - Breast Cancer KW - Cancer KW - Contraception KW - Contraceptive Methods--side effects KW - Demographic Factors KW - Diseases KW - Family Planning KW - Literature Review KW - Longterm Effects KW - Neoplasms KW - Oral Contraceptives--side effects KW - Population KW - Population Characteristics KW - Population Dynamics KW - Research Report KW - Risk Factors KW - Time Factors SP - 1379 EP - 87 JF - American journal of obstetrics and gynecology JO - Am. J. Obstet. Gynecol. VL - 163 IS - 4 Pt 2 N2 - Among women in general the risk of breast cancer through 59 years of age does not appear to be affected appreciably by the use of oral contraceptives. Nonetheless, concern continues to be expressed about the effects of early age at first use, long-term duration of use, formulation, and a variety of other factors thought to influence breast cancer risk in the presence of oral contraception. A number of recent studies restricted to young women suggest that long-term use may increase the risk of disease occurring very early, but the present lack of consistent findings in well-conducted epidemiologic studies prevents any certain conclusion with regard to cause-and-effect. However, if an increased risk were indeed present, the most plausible interpretation is that long-term oral contraception promotes earlier clinical manifestation of breast cancer in some women while having no net impact on their lifetime risk of the disease. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/2220962/Oral_contraceptives_and_breast_cancer_ L2 - http://www.diseaseinfosearch.org/result/5395 DB - PRIME DP - Unbound Medicine ER -