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Depressive symptoms in Parkinson's disease.
Compr Psychiatry. 2012 Aug; 53(6):727-31.CP

Abstract

OBJECTIVE

We aimed to investigate the relationship between the presence and severity of depression and the degree of motor and functional disability in Parkinson's disease (PD).

METHODS

One hundred twenty-two outpatients with PD were enrolled in a neurology department: 65 satisfied the Diagnostic and Statistical Manual of Mental Disorder, Fourth Edition criteria for major depression, and 57 did not (PD-C). Depressive symptoms were assessed by means of the Hamilton Rating Scale for Depression (HRSD), and the PD severity was assessed according to the Hoehn and Yahr System. Activities of daily living and motor symptoms were measured by the Unified PD Rating Scale (UPDRS), parts II and III.

RESULTS

Twenty-nine patients had a mild depression (HRSD total score ranging between 8 and 17), 30 had a moderate depression (HRSD total score ranging between 18 and 24), and 6 had a severe depression (HRSD total score, ≥25). By comparing the 3 groups of patients, it emerged that those with a severe depression showed significantly higher scores at the UPDRS II, UPDRS III, and HY scales than did PD-C or patients with a mild depression. Moreover, patients with a moderate depression scored significantly higher on the UPDRS II, UPDRS III, and HY scales than did PD-C or those with a mild depression.

CONCLUSIONS

Our findings suggest that depression and motor symptoms/well-being are highly intertwined in patients with PD.

Authors+Show Affiliations

Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnologies, University of Pisa, Via Roma 67, 56126 Pisa, Italy. a.piccinni@med.unipi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22209634

Citation

Piccinni, Armando, et al. "Depressive Symptoms in Parkinson's Disease." Comprehensive Psychiatry, vol. 53, no. 6, 2012, pp. 727-31.
Piccinni A, Marazziti D, Veltri A, et al. Depressive symptoms in Parkinson's disease. Compr Psychiatry. 2012;53(6):727-31.
Piccinni, A., Marazziti, D., Veltri, A., Ceravolo, R., Ramacciotti, C., Carlini, M., Del Debbio, A., Schiavi, E., Bonuccelli, U., & Dell'Osso, L. (2012). Depressive symptoms in Parkinson's disease. Comprehensive Psychiatry, 53(6), 727-31. https://doi.org/10.1016/j.comppsych.2011.11.002
Piccinni A, et al. Depressive Symptoms in Parkinson's Disease. Compr Psychiatry. 2012;53(6):727-31. PubMed PMID: 22209634.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depressive symptoms in Parkinson's disease. AU - Piccinni,Armando, AU - Marazziti,Donatella, AU - Veltri,Antonello, AU - Ceravolo,Roberto, AU - Ramacciotti,Carla, AU - Carlini,Marina, AU - Del Debbio,Alessandro, AU - Schiavi,Elisa, AU - Bonuccelli,Ubaldo, AU - Dell'Osso,Liliana, Y1 - 2011/12/30/ PY - 2011/08/31/received PY - 2011/11/02/revised PY - 2011/11/08/accepted PY - 2012/1/3/entrez PY - 2012/1/3/pubmed PY - 2013/1/12/medline SP - 727 EP - 31 JF - Comprehensive psychiatry JO - Compr Psychiatry VL - 53 IS - 6 N2 - OBJECTIVE: We aimed to investigate the relationship between the presence and severity of depression and the degree of motor and functional disability in Parkinson's disease (PD). METHODS: One hundred twenty-two outpatients with PD were enrolled in a neurology department: 65 satisfied the Diagnostic and Statistical Manual of Mental Disorder, Fourth Edition criteria for major depression, and 57 did not (PD-C). Depressive symptoms were assessed by means of the Hamilton Rating Scale for Depression (HRSD), and the PD severity was assessed according to the Hoehn and Yahr System. Activities of daily living and motor symptoms were measured by the Unified PD Rating Scale (UPDRS), parts II and III. RESULTS: Twenty-nine patients had a mild depression (HRSD total score ranging between 8 and 17), 30 had a moderate depression (HRSD total score ranging between 18 and 24), and 6 had a severe depression (HRSD total score, ≥25). By comparing the 3 groups of patients, it emerged that those with a severe depression showed significantly higher scores at the UPDRS II, UPDRS III, and HY scales than did PD-C or patients with a mild depression. Moreover, patients with a moderate depression scored significantly higher on the UPDRS II, UPDRS III, and HY scales than did PD-C or those with a mild depression. CONCLUSIONS: Our findings suggest that depression and motor symptoms/well-being are highly intertwined in patients with PD. SN - 1532-8384 UR - https://www.unboundmedicine.com/medline/citation/22209634/Depressive_symptoms_in_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0010-440X(11)00213-6 DB - PRIME DP - Unbound Medicine ER -