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1858 C/T polymorphism of the protein tyrosine phosphatase nonreceptor 22 gene and rheumatoid arthritis risk in europeans: a meta-analysis.
Arch Med Res. 2011 Nov; 42(8):698-702.AM

Abstract

BACKGROUND AND AIMS

A single nucleotide polymorphism (SNP) of the protein tyrosine phosphatase nonreceptor gene (PTPN22) confers susceptibility to rheumatoid arthritis (RA) and certain other classical autoimmune diseases. The association between PTPN22 1858C/T polymorphism and the risk of RA is still controversial and ambiguous; therefore, we performed this meta-analysis to confirm some relationships.

METHODS

We conducted a search in the PubMed database without a language limitation, covering all papers published until June 20, 2011. Overall, 19 case-control studies with 11,727 cases and 12,640 controls were retrieved based on the search criteria for RA susceptibility related to the 1858C/T polymorphism. Odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of this association. Publication bias was assessed with Eggers test.

RESULTS

We found that PTPN22 1858C/T polymorphism could increase RA risk in overall genetic models in Europeans (T-allele vs. C-allele, OR = 1.54, 95% CI = 1.47-1.62, P(heterogeneity) = 0.143; TT vs. CC, OR = 2.86, 95% CI = 2.29-3.57, P(heterogeneity) = 0.302; TC vs. CC, OR = 1.45, 95% CI = 1.38-1.53, P(heterogeneity) = 0.273; TT + TC vs. CC, OR = 1.49, 95% CI = 1.42-1.56, P(heterogeneity) = 0.208; TT vs. TC + CC, OR = 2.52, 95% CI = 1.95-3.25, P(heterogeneity) = 0.296). Furthermore, significant relationships were detected among PTPN22 1858C/T polymorphism and RF(+) or RF(-) RA risk. No obvious evidence of publication bias was detected in the overall analysis.

CONCLUSIONS

Our study indicated that PTPN22 1858T allele was significantly associated with increased RA risk.

Authors+Show Affiliations

Department of Orthopedics, The Affiliated Changzhou No. 2 Hospital of Nanjing Medical University, Changzhou, Jiangsu Province, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

22209972

Citation

Nong, Lu-Ming, et al. "1858 C/T Polymorphism of the Protein Tyrosine Phosphatase Nonreceptor 22 Gene and Rheumatoid Arthritis Risk in Europeans: a Meta-analysis." Archives of Medical Research, vol. 42, no. 8, 2011, pp. 698-702.
Nong LM, Ren KW, Xu NW, et al. 1858 C/T polymorphism of the protein tyrosine phosphatase nonreceptor 22 gene and rheumatoid arthritis risk in europeans: a meta-analysis. Arch Med Res. 2011;42(8):698-702.
Nong, L. M., Ren, K. W., Xu, N. W., & Zhou, D. (2011). 1858 C/T polymorphism of the protein tyrosine phosphatase nonreceptor 22 gene and rheumatoid arthritis risk in europeans: a meta-analysis. Archives of Medical Research, 42(8), 698-702. https://doi.org/10.1016/j.arcmed.2011.12.001
Nong LM, et al. 1858 C/T Polymorphism of the Protein Tyrosine Phosphatase Nonreceptor 22 Gene and Rheumatoid Arthritis Risk in Europeans: a Meta-analysis. Arch Med Res. 2011;42(8):698-702. PubMed PMID: 22209972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 1858 C/T polymorphism of the protein tyrosine phosphatase nonreceptor 22 gene and rheumatoid arthritis risk in europeans: a meta-analysis. AU - Nong,Lu-Ming, AU - Ren,Ke-Wei, AU - Xu,Nan-Wei, AU - Zhou,Dong, Y1 - 2011/12/30/ PY - 2011/06/30/received PY - 2011/12/05/accepted PY - 2012/1/3/entrez PY - 2012/1/3/pubmed PY - 2012/6/9/medline SP - 698 EP - 702 JF - Archives of medical research JO - Arch. Med. Res. VL - 42 IS - 8 N2 - BACKGROUND AND AIMS: A single nucleotide polymorphism (SNP) of the protein tyrosine phosphatase nonreceptor gene (PTPN22) confers susceptibility to rheumatoid arthritis (RA) and certain other classical autoimmune diseases. The association between PTPN22 1858C/T polymorphism and the risk of RA is still controversial and ambiguous; therefore, we performed this meta-analysis to confirm some relationships. METHODS: We conducted a search in the PubMed database without a language limitation, covering all papers published until June 20, 2011. Overall, 19 case-control studies with 11,727 cases and 12,640 controls were retrieved based on the search criteria for RA susceptibility related to the 1858C/T polymorphism. Odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of this association. Publication bias was assessed with Eggers test. RESULTS: We found that PTPN22 1858C/T polymorphism could increase RA risk in overall genetic models in Europeans (T-allele vs. C-allele, OR = 1.54, 95% CI = 1.47-1.62, P(heterogeneity) = 0.143; TT vs. CC, OR = 2.86, 95% CI = 2.29-3.57, P(heterogeneity) = 0.302; TC vs. CC, OR = 1.45, 95% CI = 1.38-1.53, P(heterogeneity) = 0.273; TT + TC vs. CC, OR = 1.49, 95% CI = 1.42-1.56, P(heterogeneity) = 0.208; TT vs. TC + CC, OR = 2.52, 95% CI = 1.95-3.25, P(heterogeneity) = 0.296). Furthermore, significant relationships were detected among PTPN22 1858C/T polymorphism and RF(+) or RF(-) RA risk. No obvious evidence of publication bias was detected in the overall analysis. CONCLUSIONS: Our study indicated that PTPN22 1858T allele was significantly associated with increased RA risk. SN - 1873-5487 UR - https://www.unboundmedicine.com/medline/citation/22209972/1858_C/T_polymorphism_of_the_protein_tyrosine_phosphatase_nonreceptor_22_gene_and_rheumatoid_arthritis_risk_in_europeans:_a_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0188-4409(11)00258-X DB - PRIME DP - Unbound Medicine ER -