Tags

Type your tag names separated by a space and hit enter

Telmisartan acts through the modulation of ACE-2/ANG 1-7/mas receptor in rats with dilated cardiomyopathy induced by experimental autoimmune myocarditis.
Life Sci. 2012 Feb 13; 90(7-8):289-300.LS

Abstract

AIM

Recent findings have suggested that a therapeutic approach to amplify or stimulate the angiotensin-converting enzyme-2 [ACE-2]-angiotensin 1-7 [ANG 1-7] mas axis could provide protection against the development of cardiovascular diseases. We investigated the cardioprotective effects of telmisartan in rats with dilated cardiomyopathy [DCM] after experimental autoimmune myocarditis [EAM].

MAIN METHODS

DCM was elicited in Lewis rats by immunization with cardiac myosin, and twenty-eight days after immunization, the surviving Lewis rats were divided into two groups and treated with either telmisartan (10mg/kg/day) or vehicle.

KEY FINDINGS

Telmisartan treatment effectively suppressed myocardial protein and mRNA expressions of inflammatory markers [CD68, iNOS, NF-kB, interleukin-1β, interferon-γ, monocyte chemotactic protein-1] in comparison to vehicle-treated rats. In contrast, myocardial protein levels of ACE-2 and ANG 1-7 mas receptor were upregulated in the telmisartan-treated group compared with vehicle-treated rats. Telmisartan treatment significantly reduced fibrosis and hypertrophy and their marker molecules [OPN, CTGF, TGF-β1 and collagens I and III and atrial natriuretic peptide and GATA-4, respectively] compared with those of vehicle-treated rats. In addition, telmisartan treatment significantly lowered the protein expressions of NADPH oxidase subunits p47phox, p67phox, and superoxide production when compared with vehicle-treated rats. Telmisartan treatment significantly decreased the expression levels of mitogen-activated protein kinase (MAPK) signaling molecules than with those of vehicle-treated rats. Also, telmisartan treatment significantly improved LV systolic and diastolic function.

SIGNIFICANCE

These results indicate that telmisartan treatment significantly improved LV function and ameliorated the progression of cardiac remodeling through the modulation of ACE-2/ANG 1-7/Mas receptor axis in rats with DCM after EAM.

Authors+Show Affiliations

Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan. svkumar1979@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22210452

Citation

Sukumaran, Vijayakumar, et al. "Telmisartan Acts Through the Modulation of ACE-2/ANG 1-7/mas Receptor in Rats With Dilated Cardiomyopathy Induced By Experimental Autoimmune Myocarditis." Life Sciences, vol. 90, no. 7-8, 2012, pp. 289-300.
Sukumaran V, Veeraveedu PT, Gurusamy N, et al. Telmisartan acts through the modulation of ACE-2/ANG 1-7/mas receptor in rats with dilated cardiomyopathy induced by experimental autoimmune myocarditis. Life Sci. 2012;90(7-8):289-300.
Sukumaran, V., Veeraveedu, P. T., Gurusamy, N., Lakshmanan, A. P., Yamaguchi, K., Ma, M., Suzuki, K., Kodama, M., & Watanabe, K. (2012). Telmisartan acts through the modulation of ACE-2/ANG 1-7/mas receptor in rats with dilated cardiomyopathy induced by experimental autoimmune myocarditis. Life Sciences, 90(7-8), 289-300. https://doi.org/10.1016/j.lfs.2011.11.018
Sukumaran V, et al. Telmisartan Acts Through the Modulation of ACE-2/ANG 1-7/mas Receptor in Rats With Dilated Cardiomyopathy Induced By Experimental Autoimmune Myocarditis. Life Sci. 2012 Feb 13;90(7-8):289-300. PubMed PMID: 22210452.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Telmisartan acts through the modulation of ACE-2/ANG 1-7/mas receptor in rats with dilated cardiomyopathy induced by experimental autoimmune myocarditis. AU - Sukumaran,Vijayakumar, AU - Veeraveedu,Punniyakoti T, AU - Gurusamy,Narasimman, AU - Lakshmanan,Arun Prasath, AU - Yamaguchi,Ken'ichi, AU - Ma,Meilei, AU - Suzuki,Kenji, AU - Kodama,Makoto, AU - Watanabe,Kenichi, Y1 - 2011/12/19/ PY - 2011/06/22/received PY - 2011/11/01/revised PY - 2011/11/30/accepted PY - 2012/1/3/entrez PY - 2012/1/3/pubmed PY - 2012/3/20/medline SP - 289 EP - 300 JF - Life sciences JO - Life Sci VL - 90 IS - 7-8 N2 - AIM: Recent findings have suggested that a therapeutic approach to amplify or stimulate the angiotensin-converting enzyme-2 [ACE-2]-angiotensin 1-7 [ANG 1-7] mas axis could provide protection against the development of cardiovascular diseases. We investigated the cardioprotective effects of telmisartan in rats with dilated cardiomyopathy [DCM] after experimental autoimmune myocarditis [EAM]. MAIN METHODS: DCM was elicited in Lewis rats by immunization with cardiac myosin, and twenty-eight days after immunization, the surviving Lewis rats were divided into two groups and treated with either telmisartan (10mg/kg/day) or vehicle. KEY FINDINGS: Telmisartan treatment effectively suppressed myocardial protein and mRNA expressions of inflammatory markers [CD68, iNOS, NF-kB, interleukin-1β, interferon-γ, monocyte chemotactic protein-1] in comparison to vehicle-treated rats. In contrast, myocardial protein levels of ACE-2 and ANG 1-7 mas receptor were upregulated in the telmisartan-treated group compared with vehicle-treated rats. Telmisartan treatment significantly reduced fibrosis and hypertrophy and their marker molecules [OPN, CTGF, TGF-β1 and collagens I and III and atrial natriuretic peptide and GATA-4, respectively] compared with those of vehicle-treated rats. In addition, telmisartan treatment significantly lowered the protein expressions of NADPH oxidase subunits p47phox, p67phox, and superoxide production when compared with vehicle-treated rats. Telmisartan treatment significantly decreased the expression levels of mitogen-activated protein kinase (MAPK) signaling molecules than with those of vehicle-treated rats. Also, telmisartan treatment significantly improved LV systolic and diastolic function. SIGNIFICANCE: These results indicate that telmisartan treatment significantly improved LV function and ameliorated the progression of cardiac remodeling through the modulation of ACE-2/ANG 1-7/Mas receptor axis in rats with DCM after EAM. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/22210452/Telmisartan_acts_through_the_modulation_of_ACE_2/ANG_1_7/mas_receptor_in_rats_with_dilated_cardiomyopathy_induced_by_experimental_autoimmune_myocarditis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(11)00580-7 DB - PRIME DP - Unbound Medicine ER -