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Ocular adnexal IgG4-related disease: comparative analysis with mucosa-associated lymphoid tissue lymphoma and other chronic inflammatory conditions.
Histopathology. 2012 Jan; 60(2):296-312.H

Abstract

AIMS

Making a differential diagnosis of IgG4-related disease from mucosa-associated lymphoid tissue (MALT) lymphoma or any other chronic inflammation is often challenging. Moreover, the association with secondary lymphoma of ocular adnexal IgG4-related disease needs to be elucidated.

METHODS AND RESULTS

We investigated 14 cases of IgG4-related disease, nine MALT lymphomas and 12 other chronic inflammations involving the lacrimal gland and orbit. Bilateral involvement was frequent in IgG4-related diseases. The number of IgG4-positive cells and the ratio of IgG4/IgG-positive cells were higher in patients with IgG4-related disease than in those with MALT lymphoma (P = 0.016; P < 0.001) and other types of inflammation (P < 0.001; P < 0.001). Monoclonal B cell proliferation was suspected in two cases (14.3%) of IgG4-related disease. One of these patients also displayed monomorphous features suggesting secondary MALT lymphoma. In the other case, κ-chain restriction in IgG4-positive cells was observed, raising the possibility of IgG4-producing MALT lymphoma. Trisomy 3, trisomy 18 or MALT1 translocation was observed in none of the IgG4-related cases. Regulatory T-cell infiltration was higher in cases of IgG4-related disease than in MALT lymphomas (P < 0.001) and other types of inflammation (P = 0.006).

CONCLUSIONS

Some genetically and morphologically complicated cases of ocular adnexal IgG4-related disease emphasize the need for in-depth studies to differentiate this disease from MALT lymphoma, and to exclude secondary lymphoma.

Authors+Show Affiliations

Department of Pathology, Seoul National University Hospital, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22211288

Citation

Go, Heounjeong, et al. "Ocular Adnexal IgG4-related Disease: Comparative Analysis With Mucosa-associated Lymphoid Tissue Lymphoma and Other Chronic Inflammatory Conditions." Histopathology, vol. 60, no. 2, 2012, pp. 296-312.
Go H, Kim JE, Kim YA, et al. Ocular adnexal IgG4-related disease: comparative analysis with mucosa-associated lymphoid tissue lymphoma and other chronic inflammatory conditions. Histopathology. 2012;60(2):296-312.
Go, H., Kim, J. E., Kim, Y. A., Chung, H. K., Khwarg, S. I., Kim, C. W., & Jeon, Y. K. (2012). Ocular adnexal IgG4-related disease: comparative analysis with mucosa-associated lymphoid tissue lymphoma and other chronic inflammatory conditions. Histopathology, 60(2), 296-312. https://doi.org/10.1111/j.1365-2559.2011.04089.x
Go H, et al. Ocular Adnexal IgG4-related Disease: Comparative Analysis With Mucosa-associated Lymphoid Tissue Lymphoma and Other Chronic Inflammatory Conditions. Histopathology. 2012;60(2):296-312. PubMed PMID: 22211288.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ocular adnexal IgG4-related disease: comparative analysis with mucosa-associated lymphoid tissue lymphoma and other chronic inflammatory conditions. AU - Go,Heounjeong, AU - Kim,Ji Eun, AU - Kim,Young A, AU - Chung,Ho Kyung, AU - Khwarg,Sang In, AU - Kim,Chul-Woo, AU - Jeon,Yoon Kyung, PY - 2012/1/4/entrez PY - 2012/1/4/pubmed PY - 2012/5/30/medline SP - 296 EP - 312 JF - Histopathology JO - Histopathology VL - 60 IS - 2 N2 - AIMS: Making a differential diagnosis of IgG4-related disease from mucosa-associated lymphoid tissue (MALT) lymphoma or any other chronic inflammation is often challenging. Moreover, the association with secondary lymphoma of ocular adnexal IgG4-related disease needs to be elucidated. METHODS AND RESULTS: We investigated 14 cases of IgG4-related disease, nine MALT lymphomas and 12 other chronic inflammations involving the lacrimal gland and orbit. Bilateral involvement was frequent in IgG4-related diseases. The number of IgG4-positive cells and the ratio of IgG4/IgG-positive cells were higher in patients with IgG4-related disease than in those with MALT lymphoma (P = 0.016; P < 0.001) and other types of inflammation (P < 0.001; P < 0.001). Monoclonal B cell proliferation was suspected in two cases (14.3%) of IgG4-related disease. One of these patients also displayed monomorphous features suggesting secondary MALT lymphoma. In the other case, κ-chain restriction in IgG4-positive cells was observed, raising the possibility of IgG4-producing MALT lymphoma. Trisomy 3, trisomy 18 or MALT1 translocation was observed in none of the IgG4-related cases. Regulatory T-cell infiltration was higher in cases of IgG4-related disease than in MALT lymphomas (P < 0.001) and other types of inflammation (P = 0.006). CONCLUSIONS: Some genetically and morphologically complicated cases of ocular adnexal IgG4-related disease emphasize the need for in-depth studies to differentiate this disease from MALT lymphoma, and to exclude secondary lymphoma. SN - 1365-2559 UR - https://www.unboundmedicine.com/medline/citation/22211288/Ocular_adnexal_IgG4_related_disease:_comparative_analysis_with_mucosa_associated_lymphoid_tissue_lymphoma_and_other_chronic_inflammatory_conditions_ L2 - https://doi.org/10.1111/j.1365-2559.2011.04089.x DB - PRIME DP - Unbound Medicine ER -