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Intake of antioxidant nutrients and risk of non-Hodgkin's Lymphoma in the Women's Health Initiative.
Nutr Cancer 2012; 64(2):245-54NC

Abstract

Incidence rates of non-Hodgkin's lymphoma (NHL) increased substantially in the United States and worldwide during the latter part of the 20(th) century, but little is known about the etiology of this condition. Antioxidant nutrients may reduce the risk of NHL by quenching free radicals, which may contribute to carcinogenesis by damaging DNA and lipid membranes. We examined the association of intake of vitamin A and antioxidant nutrients with risk of NHL and its major subtypes in 1,104 cases of NHL identified among 154,363 postmenopausal women followed for an average of 11 yr in the Women's Health Initiative. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). Of all nutrients examined, only total vitamin A intake (from diet and supplements combined) was inversely associated with risk of NHL overall (multivariate adjusted HR for highest vs. lowest quartile 0.83, 95% CI 0.69-0.99), whereas total vitamin C intake was inversely associated with risk of diffuse large B-cell lymphoma (HR for highest vs. lowest quartile 0.69, 95% CI 0.49-0.98). Overall, this study provides some evidence of inverse associations of intake of total vitamin A and total vitamin C with the risk of NHL and diffuse lymphoma, respectively.

Authors+Show Affiliations

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA. geoffrey.kabat@einstein.yu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

22211937

Citation

Kabat, Geoffrey C., et al. "Intake of Antioxidant Nutrients and Risk of non-Hodgkin's Lymphoma in the Women's Health Initiative." Nutrition and Cancer, vol. 64, no. 2, 2012, pp. 245-54.
Kabat GC, Kim MY, Wactawski-Wende J, et al. Intake of antioxidant nutrients and risk of non-Hodgkin's Lymphoma in the Women's Health Initiative. Nutr Cancer. 2012;64(2):245-54.
Kabat, G. C., Kim, M. Y., Wactawski-Wende, J., Shikany, J. M., Vitolins, M. Z., & Rohan, T. E. (2012). Intake of antioxidant nutrients and risk of non-Hodgkin's Lymphoma in the Women's Health Initiative. Nutrition and Cancer, 64(2), pp. 245-54. doi:10.1080/01635581.2012.642454.
Kabat GC, et al. Intake of Antioxidant Nutrients and Risk of non-Hodgkin's Lymphoma in the Women's Health Initiative. Nutr Cancer. 2012;64(2):245-54. PubMed PMID: 22211937.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of antioxidant nutrients and risk of non-Hodgkin's Lymphoma in the Women's Health Initiative. AU - Kabat,Geoffrey C, AU - Kim,Mimi Y, AU - Wactawski-Wende,Jean, AU - Shikany,James M, AU - Vitolins,Mara Z, AU - Rohan,Thomas E, Y1 - 2012/01/02/ PY - 2012/1/4/entrez PY - 2012/1/4/pubmed PY - 2012/6/16/medline SP - 245 EP - 54 JF - Nutrition and cancer JO - Nutr Cancer VL - 64 IS - 2 N2 - Incidence rates of non-Hodgkin's lymphoma (NHL) increased substantially in the United States and worldwide during the latter part of the 20(th) century, but little is known about the etiology of this condition. Antioxidant nutrients may reduce the risk of NHL by quenching free radicals, which may contribute to carcinogenesis by damaging DNA and lipid membranes. We examined the association of intake of vitamin A and antioxidant nutrients with risk of NHL and its major subtypes in 1,104 cases of NHL identified among 154,363 postmenopausal women followed for an average of 11 yr in the Women's Health Initiative. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). Of all nutrients examined, only total vitamin A intake (from diet and supplements combined) was inversely associated with risk of NHL overall (multivariate adjusted HR for highest vs. lowest quartile 0.83, 95% CI 0.69-0.99), whereas total vitamin C intake was inversely associated with risk of diffuse large B-cell lymphoma (HR for highest vs. lowest quartile 0.69, 95% CI 0.49-0.98). Overall, this study provides some evidence of inverse associations of intake of total vitamin A and total vitamin C with the risk of NHL and diffuse lymphoma, respectively. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/22211937/Intake_of_antioxidant_nutrients_and_risk_of_non_Hodgkin's_Lymphoma_in_the_Women's_Health_Initiative_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635581.2012.642454 DB - PRIME DP - Unbound Medicine ER -