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Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart Study.
Arch Neurol 2012; 69(5):594-600AN

Abstract

OBJECTIVE

To investigate the contribution of biomarkers of glucose homeostasis (adiponectin, glucose, glycated albumin, and insulin levels) and inflammation (high-sensitivity C-reactive protein and lipoprotein-associated phospholipase A(2) levels) to the risk of developing Alzheimer disease (AD) and all-cause dementia.

DESIGN

Prospective cohort study.

SETTING

Dementia-free Framingham Heart Study participants had sera measured for these biomarkers at the 19th biennial examination (1985-1988) and were followed up prospectively for the development of AD and all-cause dementia.

PARTICIPANTS

Eight hundred forty (541 women, median age of 76 years) subjects participated in the study.

MAIN OUTCOME MEASURES

We used sex-pooled and sex-specific multivariable Cox proportional hazards models adjusted for age, education, body mass index, recent change in weight, APOE ε4 allele status, and plasma docosahexaenoic acid levels to determine association of these biomarkers with the development of all-cause dementia and AD.

RESULTS

Over a mean follow-up period of 13 years, 159 persons developed dementia (including 125 with AD). After adjustment for other risk factors, only adiponectin in women was associated with an increased risk of all-cause dementia (hazard ratio [HR], 1.29; 95% confidence interval [CI], 1.00-1.66; P=.054) and AD (HR, 1.33; 95% CI, 1.00-1.76; P=.050) per 1-SD increase in adiponectin level. Women with baseline adiponectin values more than the median had a higher risk of all-cause dementia (HR, 1.63; 95% CI, 1.03-2.56; P=.04) and AD (HR, 1.87; 95% CI, 1.13-3.10; P=.01) as compared with those with values less than the median.

CONCLUSION

In women, increased plasma adiponectin levels are an independent risk factor for the development of both all-cause dementia and AD.

Authors+Show Affiliations

Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

22213409

Citation

van Himbergen, Thomas M., et al. "Biomarkers for Insulin Resistance and Inflammation and the Risk for All-cause Dementia and Alzheimer Disease: Results From the Framingham Heart Study." Archives of Neurology, vol. 69, no. 5, 2012, pp. 594-600.
van Himbergen TM, Beiser AS, Ai M, et al. Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart Study. Arch Neurol. 2012;69(5):594-600.
van Himbergen, T. M., Beiser, A. S., Ai, M., Seshadri, S., Otokozawa, S., Au, R., ... Schaefer, E. J. (2012). Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart Study. Archives of Neurology, 69(5), pp. 594-600.
van Himbergen TM, et al. Biomarkers for Insulin Resistance and Inflammation and the Risk for All-cause Dementia and Alzheimer Disease: Results From the Framingham Heart Study. Arch Neurol. 2012;69(5):594-600. PubMed PMID: 22213409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart Study. AU - van Himbergen,Thomas M, AU - Beiser,Alexa S, AU - Ai,Masumi, AU - Seshadri,Sudha, AU - Otokozawa,Seiko, AU - Au,Rhoda, AU - Thongtang,Nuntakorn, AU - Wolf,Philip A, AU - Schaefer,Ernst J, PY - 2012/1/4/entrez PY - 2012/1/4/pubmed PY - 2012/12/10/medline SP - 594 EP - 600 JF - Archives of neurology JO - Arch. Neurol. VL - 69 IS - 5 N2 - OBJECTIVE: To investigate the contribution of biomarkers of glucose homeostasis (adiponectin, glucose, glycated albumin, and insulin levels) and inflammation (high-sensitivity C-reactive protein and lipoprotein-associated phospholipase A(2) levels) to the risk of developing Alzheimer disease (AD) and all-cause dementia. DESIGN: Prospective cohort study. SETTING: Dementia-free Framingham Heart Study participants had sera measured for these biomarkers at the 19th biennial examination (1985-1988) and were followed up prospectively for the development of AD and all-cause dementia. PARTICIPANTS: Eight hundred forty (541 women, median age of 76 years) subjects participated in the study. MAIN OUTCOME MEASURES: We used sex-pooled and sex-specific multivariable Cox proportional hazards models adjusted for age, education, body mass index, recent change in weight, APOE ε4 allele status, and plasma docosahexaenoic acid levels to determine association of these biomarkers with the development of all-cause dementia and AD. RESULTS: Over a mean follow-up period of 13 years, 159 persons developed dementia (including 125 with AD). After adjustment for other risk factors, only adiponectin in women was associated with an increased risk of all-cause dementia (hazard ratio [HR], 1.29; 95% confidence interval [CI], 1.00-1.66; P=.054) and AD (HR, 1.33; 95% CI, 1.00-1.76; P=.050) per 1-SD increase in adiponectin level. Women with baseline adiponectin values more than the median had a higher risk of all-cause dementia (HR, 1.63; 95% CI, 1.03-2.56; P=.04) and AD (HR, 1.87; 95% CI, 1.13-3.10; P=.01) as compared with those with values less than the median. CONCLUSION: In women, increased plasma adiponectin levels are an independent risk factor for the development of both all-cause dementia and AD. SN - 1538-3687 UR - http://www.unboundmedicine.com/medline/citation/22213409/Biomarkers_for_insulin_resistance_and_inflammation_and_the_risk_for_all_cause_dementia_and_alzheimer_disease:_results_from_the_Framingham_Heart_Study_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneurol.2011.670 DB - PRIME DP - Unbound Medicine ER -