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Chronic obstructive pulmonary disease and cancer risk: a Danish nationwide cohort study.
Respir Med. 2012 Jun; 106(6):845-52.RM

Abstract

INTRODUCTION

Little is known about the risk of cancer in patients with chronic obstructive pulmonary disease (COPD), including which cancer sites are most affected. We examined the short- and long-term risk of lung and extrapulmonary cancer in a nationwide cohort of COPD patients.

METHODS

We linked the Danish National Registry of Patients and the nationwide cancer registry, and examined the incidence of various cancers in 236,494 individuals with a first incident hospital contact with COPD during 1980-2008. The observed cancer incidence in this cohort was compared with the expected incidence in the general population on the basis of national age-, sex-, and site-specific incidence rates.

RESULTS

Median follow-up was 3.5 years. During the first year of follow-up, 9434 cancers were diagnosed in COPD patients [standardized incidence ratio (SIR) = 3.1; 95% CI 3.0 to 3.2]. The 1-year SIR was 8.5 (8.2-8.9) for lung cancer, 5.1 (5.0-5.2) for all tobacco-related cancers, and 1.9 (1.9-2.0) for other cancers. In the following years, cancer incidence was increased 1.4-fold (1.4-1.5) in COPD patients. These patients had an increased risk of developing tobacco-related cancers (SIR = 2.1; 95% CI 2.0-2.1), including cancers of the lung, larynx, tongue, oral cavity, pharynx, esophagus, stomach, liver, pancreas, cervix uteri, and urinary tract (with SIRs ranging between 1.3 and 2.8).

CONCLUSIONS

Patients with first-time hospital-diagnosed COPD are at considerably increased risk of developing both lung cancer and extrapulmonary cancers. Physicians should be aware of cancer in COPD patients.

Authors+Show Affiliations

Department of Clinical Epidemiology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus N DK-8200, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22214771

Citation

Kornum, Jette Brommann, et al. "Chronic Obstructive Pulmonary Disease and Cancer Risk: a Danish Nationwide Cohort Study." Respiratory Medicine, vol. 106, no. 6, 2012, pp. 845-52.
Kornum JB, Sværke C, Thomsen RW, et al. Chronic obstructive pulmonary disease and cancer risk: a Danish nationwide cohort study. Respir Med. 2012;106(6):845-52.
Kornum, J. B., Sværke, C., Thomsen, R. W., Lange, P., & Sørensen, H. T. (2012). Chronic obstructive pulmonary disease and cancer risk: a Danish nationwide cohort study. Respiratory Medicine, 106(6), 845-52. https://doi.org/10.1016/j.rmed.2011.12.009
Kornum JB, et al. Chronic Obstructive Pulmonary Disease and Cancer Risk: a Danish Nationwide Cohort Study. Respir Med. 2012;106(6):845-52. PubMed PMID: 22214771.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic obstructive pulmonary disease and cancer risk: a Danish nationwide cohort study. AU - Kornum,Jette Brommann, AU - Sværke,Claus, AU - Thomsen,Reimar Wernich, AU - Lange,Peter, AU - Sørensen,Henrik Toft, Y1 - 2012/01/02/ PY - 2011/10/22/received PY - 2011/12/12/accepted PY - 2012/1/5/entrez PY - 2012/1/5/pubmed PY - 2012/6/20/medline SP - 845 EP - 52 JF - Respiratory medicine JO - Respir Med VL - 106 IS - 6 N2 - INTRODUCTION: Little is known about the risk of cancer in patients with chronic obstructive pulmonary disease (COPD), including which cancer sites are most affected. We examined the short- and long-term risk of lung and extrapulmonary cancer in a nationwide cohort of COPD patients. METHODS: We linked the Danish National Registry of Patients and the nationwide cancer registry, and examined the incidence of various cancers in 236,494 individuals with a first incident hospital contact with COPD during 1980-2008. The observed cancer incidence in this cohort was compared with the expected incidence in the general population on the basis of national age-, sex-, and site-specific incidence rates. RESULTS: Median follow-up was 3.5 years. During the first year of follow-up, 9434 cancers were diagnosed in COPD patients [standardized incidence ratio (SIR) = 3.1; 95% CI 3.0 to 3.2]. The 1-year SIR was 8.5 (8.2-8.9) for lung cancer, 5.1 (5.0-5.2) for all tobacco-related cancers, and 1.9 (1.9-2.0) for other cancers. In the following years, cancer incidence was increased 1.4-fold (1.4-1.5) in COPD patients. These patients had an increased risk of developing tobacco-related cancers (SIR = 2.1; 95% CI 2.0-2.1), including cancers of the lung, larynx, tongue, oral cavity, pharynx, esophagus, stomach, liver, pancreas, cervix uteri, and urinary tract (with SIRs ranging between 1.3 and 2.8). CONCLUSIONS: Patients with first-time hospital-diagnosed COPD are at considerably increased risk of developing both lung cancer and extrapulmonary cancers. Physicians should be aware of cancer in COPD patients. SN - 1532-3064 UR - https://www.unboundmedicine.com/medline/citation/22214771/Chronic_obstructive_pulmonary_disease_and_cancer_risk:_a_Danish_nationwide_cohort_study_ DB - PRIME DP - Unbound Medicine ER -