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Expression pattern of osteopontin and αvβ3 integrin during the implantation window in infertile patients with early stages of endometriosis.
Hum Reprod. 2012 Mar; 27(3):805-13.HR

Abstract

BACKGROUND

To study endometrial receptivity in terms of osteopontin (OPN) and αvβ3 integrin expression and co-expression in infertile women with early stages of endometriosis.

METHODS

We investigated the immunohistochemical expression and co-expression of OPN and αvβ3 integrin in the endometrium of 20 infertile patients with Stage I or II endometriosis as the only detectable cause of infertility, 20 infertile patients with unexplained infertility and 20 fertile women undergoing tubal sterilization. Two endometrial biopsies were performed during a single menstrual cycle (postovulatory Day +7 to +8 and 4 days later) in each subject.

RESULTS

No statistically significant differences regarding OPN and αvβ3 integrin expression were found between infertile patients with endometriosis and the two control groups. There was no significant correlation between OPN and αvβ3 integrin staining intensity in the mid-luteal phase biopsies in any of the groups studied.

CONCLUSIONS

Endometrial OPN and αvβ3 integrin expression or co-expression is not impaired during the window of implantation in patients with Stage I-II endometriosis. Further studies are needed to determine whether these results imply normal endometrial receptivity in such patients or add to the increasing uncertainty about the clinical value of assessing the endometrium with these markers of implantation.

Authors+Show Affiliations

Institut Clinic of Gynaecology, Obstetrics and Neonatology, Hospital Clínic - Institut d'Investigacions Biomèdiques August Pi i Sunyer, c/Casanova 143, 08036 Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22215628

Citation

Casals, Gemma, et al. "Expression Pattern of Osteopontin and Αvβ3 Integrin During the Implantation Window in Infertile Patients With Early Stages of Endometriosis." Human Reproduction (Oxford, England), vol. 27, no. 3, 2012, pp. 805-13.
Casals G, Ordi J, Creus M, et al. Expression pattern of osteopontin and αvβ3 integrin during the implantation window in infertile patients with early stages of endometriosis. Hum Reprod. 2012;27(3):805-13.
Casals, G., Ordi, J., Creus, M., Fábregues, F., Carmona, F., Casamitjana, R., & Balasch, J. (2012). Expression pattern of osteopontin and αvβ3 integrin during the implantation window in infertile patients with early stages of endometriosis. Human Reproduction (Oxford, England), 27(3), 805-13. https://doi.org/10.1093/humrep/der432
Casals G, et al. Expression Pattern of Osteopontin and Αvβ3 Integrin During the Implantation Window in Infertile Patients With Early Stages of Endometriosis. Hum Reprod. 2012;27(3):805-13. PubMed PMID: 22215628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression pattern of osteopontin and αvβ3 integrin during the implantation window in infertile patients with early stages of endometriosis. AU - Casals,Gemma, AU - Ordi,Jaume, AU - Creus,Montse, AU - Fábregues,Francisco, AU - Carmona,Francisco, AU - Casamitjana,Roser, AU - Balasch,Juan, Y1 - 2012/01/02/ PY - 2012/1/5/entrez PY - 2012/1/5/pubmed PY - 2012/11/9/medline SP - 805 EP - 13 JF - Human reproduction (Oxford, England) JO - Hum. Reprod. VL - 27 IS - 3 N2 - BACKGROUND: To study endometrial receptivity in terms of osteopontin (OPN) and αvβ3 integrin expression and co-expression in infertile women with early stages of endometriosis. METHODS: We investigated the immunohistochemical expression and co-expression of OPN and αvβ3 integrin in the endometrium of 20 infertile patients with Stage I or II endometriosis as the only detectable cause of infertility, 20 infertile patients with unexplained infertility and 20 fertile women undergoing tubal sterilization. Two endometrial biopsies were performed during a single menstrual cycle (postovulatory Day +7 to +8 and 4 days later) in each subject. RESULTS: No statistically significant differences regarding OPN and αvβ3 integrin expression were found between infertile patients with endometriosis and the two control groups. There was no significant correlation between OPN and αvβ3 integrin staining intensity in the mid-luteal phase biopsies in any of the groups studied. CONCLUSIONS: Endometrial OPN and αvβ3 integrin expression or co-expression is not impaired during the window of implantation in patients with Stage I-II endometriosis. Further studies are needed to determine whether these results imply normal endometrial receptivity in such patients or add to the increasing uncertainty about the clinical value of assessing the endometrium with these markers of implantation. SN - 1460-2350 UR - https://www.unboundmedicine.com/medline/citation/22215628/Expression_pattern_of_osteopontin_and_αvβ3_integrin_during_the_implantation_window_in_infertile_patients_with_early_stages_of_endometriosis_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/der432 DB - PRIME DP - Unbound Medicine ER -