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Comparative study of color Doppler voiding urosonography without contrast enhancement and direct radionuclide voiding cystography for diagnosis of vesicoureteric reflux in children.
J Ultrasound Med. 2012 Jan; 31(1):55-61.JU

Abstract

OBJECTIVES

Most available studies investigating the diagnostic accuracy of color Doppler voiding urosonography in the detection of vesicoureteric reflux used an echo contrast agent. It is unknown whether echo contrast agents are necessary for diagnosis or follow-up of vesicoureteric reflux. We compared color Doppler voiding urosonography without contrast enhancement and direct radionuclide voiding cystography in the detection and grading of vesicoureteric reflux with respect to the sex and age of patients as well as the severity of reflux.

METHODS

In the 66 patients enrolled (56 girls and 10 boys), 132 renoureteral units were investigated. All patients under went Doppler voiding urosonography and direct radionuclide voiding cystography within 3 hours. Direct radionuclide voiding cystography was used as the reference standard.

RESULTS

Our results indicate good overall sensitivity (83%) and specificity (77%) for color Doppler voiding urosonography without contrast enhancement in comparison with direct radionuclide voiding cystography. As the age of the patients decreased, the sensitivity of urosonography increased, reaching 100% among patients younger than 1 year. In the comparison of different grades of reflux severity, we found that the sensitivity and specificity were elevated as the grade increased (both parameters reaching 100% in the most severe cases). Severity grading was equal between the two methods.

CONCLUSIONS

We have shown that Doppler voiding urosonography without contrast enhancement is a comparably reliable method versus direct radionuclide voiding cystography in the detection and grading of vesicoureteric reflux, especially at higher grades of reflux and in children younger than 1 year.

Authors+Show Affiliations

Department of Urology, Urmia University of Medical Sciences, Urmia, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22215770

Citation

Fallah, Mohammadreza Mohammadi, et al. "Comparative Study of Color Doppler Voiding Urosonography Without Contrast Enhancement and Direct Radionuclide Voiding Cystography for Diagnosis of Vesicoureteric Reflux in Children." Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine, vol. 31, no. 1, 2012, pp. 55-61.
Fallah MM, Falahati M, Mohammadi A, et al. Comparative study of color Doppler voiding urosonography without contrast enhancement and direct radionuclide voiding cystography for diagnosis of vesicoureteric reflux in children. J Ultrasound Med. 2012;31(1):55-61.
Fallah, M. M., Falahati, M., Mohammadi, A., Alizadeh, M., Mladkova-Suchy, N., & Ghasemi-Rad, M. (2012). Comparative study of color Doppler voiding urosonography without contrast enhancement and direct radionuclide voiding cystography for diagnosis of vesicoureteric reflux in children. Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine, 31(1), 55-61.
Fallah MM, et al. Comparative Study of Color Doppler Voiding Urosonography Without Contrast Enhancement and Direct Radionuclide Voiding Cystography for Diagnosis of Vesicoureteric Reflux in Children. J Ultrasound Med. 2012;31(1):55-61. PubMed PMID: 22215770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative study of color Doppler voiding urosonography without contrast enhancement and direct radionuclide voiding cystography for diagnosis of vesicoureteric reflux in children. AU - Fallah,Mohammadreza Mohammadi, AU - Falahati,Mehdi, AU - Mohammadi,Afshin, AU - Alizadeh,Mansour, AU - Mladkova-Suchy,Nikol, AU - Ghasemi-Rad,Mohammad, PY - 2012/1/5/entrez PY - 2012/1/5/pubmed PY - 2012/4/19/medline SP - 55 EP - 61 JF - Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine JO - J Ultrasound Med VL - 31 IS - 1 N2 - OBJECTIVES: Most available studies investigating the diagnostic accuracy of color Doppler voiding urosonography in the detection of vesicoureteric reflux used an echo contrast agent. It is unknown whether echo contrast agents are necessary for diagnosis or follow-up of vesicoureteric reflux. We compared color Doppler voiding urosonography without contrast enhancement and direct radionuclide voiding cystography in the detection and grading of vesicoureteric reflux with respect to the sex and age of patients as well as the severity of reflux. METHODS: In the 66 patients enrolled (56 girls and 10 boys), 132 renoureteral units were investigated. All patients under went Doppler voiding urosonography and direct radionuclide voiding cystography within 3 hours. Direct radionuclide voiding cystography was used as the reference standard. RESULTS: Our results indicate good overall sensitivity (83%) and specificity (77%) for color Doppler voiding urosonography without contrast enhancement in comparison with direct radionuclide voiding cystography. As the age of the patients decreased, the sensitivity of urosonography increased, reaching 100% among patients younger than 1 year. In the comparison of different grades of reflux severity, we found that the sensitivity and specificity were elevated as the grade increased (both parameters reaching 100% in the most severe cases). Severity grading was equal between the two methods. CONCLUSIONS: We have shown that Doppler voiding urosonography without contrast enhancement is a comparably reliable method versus direct radionuclide voiding cystography in the detection and grading of vesicoureteric reflux, especially at higher grades of reflux and in children younger than 1 year. SN - 1550-9613 UR - https://www.unboundmedicine.com/medline/citation/22215770/Comparative_study_of_color_Doppler_voiding_urosonography_without_contrast_enhancement_and_direct_radionuclide_voiding_cystography_for_diagnosis_of_vesicoureteric_reflux_in_children_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0278-4297&date=2012&volume=31&issue=1&spage=55 DB - PRIME DP - Unbound Medicine ER -