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Evaluation of plasma N-terminal pro-B-type natriuretic peptide concentrations in dogs with and without cardiac disease.
J Am Vet Med Assoc. 2012 Jan 15; 240(2):171-80.JA

Abstract

OBJECTIVE

To evaluate plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations in a large, diverse population of dogs with and without cardiac disease and to define the upper reference limit for the biomarker in this species.

DESIGN

Cross-sectional single center study.

ANIMALS

1,134 dogs.

PROCEDURES

Dogs underwent blood sample collection, physical examination, ECG, and echocardiographic and thoracic radiographic evaluations. Cardiac status was graded by use of a 9-grade cardiac disease classification system and a simplified 4-stage cardiac scoring system. Vertebral heart score (VHS) was assessed in 280 dogs. Associations of plasma NT-proBNP concentrations with multiple variables were evaluated via univariate and multivariate linear regression analysis. Sensitivity and specificity of NT-proBNP concentrations and of VHS to discriminate between dogs with and without clinical signs of cardiac disease were evaluated via receiver-operating characteristic curve analysis.

RESULTS

974 dogs had cardiac disease, 37 had noncardiac-related disease, and 123 were healthy. Plasma NT-proBNP concentrations correlated with cardiac grade and stage; VHS was also associated with cardiac grade. At a cutoff of 874 pmol/L, sensitivity and specificity of NT-proBNP concentration to detect clinical signs of cardiac disease were 70% and 83%, respectively; for VHS, sensitivity and specificity were 56% and 85%, respectively, at a cutoff of 11.5. Mean NT-proBNP concentration was significantly increased in dogs with cardiac-related dyspnea or coughing, compared with dogs in which these signs were noncardiac related.

CONCLUSIONS AND CLINICAL RELEVANCE

Results suggested that 900 pmol/L is the upper reference limit of plasma NT-proBNP concentration in dogs. This biomarker may be a useful tool for staging of cardiac disease and identifying cardiac-related coughing or dyspnea in this species.

Authors+Show Affiliations

California Animal Hospital Veterinary Specialty Group, 1736 S Sepulveda Ave, Los Angeles, CA 90025, USA. settingerdvm@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22217025

Citation

Ettinger, Stephen J., et al. "Evaluation of Plasma N-terminal pro-B-type Natriuretic Peptide Concentrations in Dogs With and Without Cardiac Disease." Journal of the American Veterinary Medical Association, vol. 240, no. 2, 2012, pp. 171-80.
Ettinger SJ, Farace G, Forney SD, et al. Evaluation of plasma N-terminal pro-B-type natriuretic peptide concentrations in dogs with and without cardiac disease. J Am Vet Med Assoc. 2012;240(2):171-80.
Ettinger, S. J., Farace, G., Forney, S. D., Frye, M., & Beardow, A. (2012). Evaluation of plasma N-terminal pro-B-type natriuretic peptide concentrations in dogs with and without cardiac disease. Journal of the American Veterinary Medical Association, 240(2), 171-80. https://doi.org/10.2460/javma.240.2.171
Ettinger SJ, et al. Evaluation of Plasma N-terminal pro-B-type Natriuretic Peptide Concentrations in Dogs With and Without Cardiac Disease. J Am Vet Med Assoc. 2012 Jan 15;240(2):171-80. PubMed PMID: 22217025.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of plasma N-terminal pro-B-type natriuretic peptide concentrations in dogs with and without cardiac disease. AU - Ettinger,Stephen J, AU - Farace,Giosi, AU - Forney,Scott D, AU - Frye,Michelle, AU - Beardow,Andrew, PY - 2012/1/6/entrez PY - 2012/1/6/pubmed PY - 2012/4/28/medline SP - 171 EP - 80 JF - Journal of the American Veterinary Medical Association JO - J Am Vet Med Assoc VL - 240 IS - 2 N2 - OBJECTIVE: To evaluate plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations in a large, diverse population of dogs with and without cardiac disease and to define the upper reference limit for the biomarker in this species. DESIGN: Cross-sectional single center study. ANIMALS: 1,134 dogs. PROCEDURES: Dogs underwent blood sample collection, physical examination, ECG, and echocardiographic and thoracic radiographic evaluations. Cardiac status was graded by use of a 9-grade cardiac disease classification system and a simplified 4-stage cardiac scoring system. Vertebral heart score (VHS) was assessed in 280 dogs. Associations of plasma NT-proBNP concentrations with multiple variables were evaluated via univariate and multivariate linear regression analysis. Sensitivity and specificity of NT-proBNP concentrations and of VHS to discriminate between dogs with and without clinical signs of cardiac disease were evaluated via receiver-operating characteristic curve analysis. RESULTS: 974 dogs had cardiac disease, 37 had noncardiac-related disease, and 123 were healthy. Plasma NT-proBNP concentrations correlated with cardiac grade and stage; VHS was also associated with cardiac grade. At a cutoff of 874 pmol/L, sensitivity and specificity of NT-proBNP concentration to detect clinical signs of cardiac disease were 70% and 83%, respectively; for VHS, sensitivity and specificity were 56% and 85%, respectively, at a cutoff of 11.5. Mean NT-proBNP concentration was significantly increased in dogs with cardiac-related dyspnea or coughing, compared with dogs in which these signs were noncardiac related. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that 900 pmol/L is the upper reference limit of plasma NT-proBNP concentration in dogs. This biomarker may be a useful tool for staging of cardiac disease and identifying cardiac-related coughing or dyspnea in this species. SN - 1943-569X UR - https://www.unboundmedicine.com/medline/citation/22217025/Evaluation_of_plasma_N_terminal_pro_B_type_natriuretic_peptide_concentrations_in_dogs_with_and_without_cardiac_disease_ L2 - https://avmajournals.avma.org/doi/10.2460/javma.240.2.171?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -