Tags

Type your tag names separated by a space and hit enter

[Approaches to vitamin B12 deficiency].
Ned Tijdschr Geneeskd. 2012; 156(1):A3595.NT

Abstract

A 28-year-old female vegetarian was referred to a specialist in internal medicine with persistent iron deficiency. Laboratory analysis revealed microcytic anaemia with low ferritin levels but normal total vitamin B12 levels. The red blood cell distribution width, however, showed a very wide variation in red blood cell sizes, indicating a coexisting vitamin B12 deficiency, which was confirmed by the low concentration of active vitamin B12. Another patient, a 69-year-old woman with a history of previous gastric surgery and renal insufficiency as a complication of diabetes mellitus, was suspected to be deficient in vitamin B12, as she had low total vitamin B12 levels and an accumulation of methylmalonic acid and homocysteine in her blood. Testing the total concentration of vitamin B12 alone has insufficient diagnostic accuracy and no accepted gold standard is available for diagnosing vitamin B12 deficiency. With the development of newer tests, such as measuring holotranscobalamin II (concentration of active vitamin B12), atypical and subclinical deficiency states can be recognized. A new approach to diagnosing vitamin B12 deficiency is presented, based upon these 2 case descriptions.

Authors+Show Affiliations

Erasmus Medisch Centrum, afd. Klinische Chemie, Rotterdam, the Netherlands. h.russcher@erasmusmc.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

dut

PubMed ID

22217304

Citation

Russcher, Henk, et al. "[Approaches to Vitamin B12 Deficiency]." Nederlands Tijdschrift Voor Geneeskunde, vol. 156, no. 1, 2012, pp. A3595.
Russcher H, Heil SG, Slobbe L, et al. [Approaches to vitamin B12 deficiency]. Ned Tijdschr Geneeskd. 2012;156(1):A3595.
Russcher, H., Heil, S. G., Slobbe, L., & Lindemans, J. (2012). [Approaches to vitamin B12 deficiency]. Nederlands Tijdschrift Voor Geneeskunde, 156(1), A3595.
Russcher H, et al. [Approaches to Vitamin B12 Deficiency]. Ned Tijdschr Geneeskd. 2012;156(1):A3595. PubMed PMID: 22217304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Approaches to vitamin B12 deficiency]. AU - Russcher,Henk, AU - Heil,Sandra G, AU - Slobbe,Lennert, AU - Lindemans,Jan, PY - 2012/1/6/entrez PY - 2012/1/6/pubmed PY - 2012/2/18/medline SP - A3595 EP - A3595 JF - Nederlands tijdschrift voor geneeskunde JO - Ned Tijdschr Geneeskd VL - 156 IS - 1 N2 - A 28-year-old female vegetarian was referred to a specialist in internal medicine with persistent iron deficiency. Laboratory analysis revealed microcytic anaemia with low ferritin levels but normal total vitamin B12 levels. The red blood cell distribution width, however, showed a very wide variation in red blood cell sizes, indicating a coexisting vitamin B12 deficiency, which was confirmed by the low concentration of active vitamin B12. Another patient, a 69-year-old woman with a history of previous gastric surgery and renal insufficiency as a complication of diabetes mellitus, was suspected to be deficient in vitamin B12, as she had low total vitamin B12 levels and an accumulation of methylmalonic acid and homocysteine in her blood. Testing the total concentration of vitamin B12 alone has insufficient diagnostic accuracy and no accepted gold standard is available for diagnosing vitamin B12 deficiency. With the development of newer tests, such as measuring holotranscobalamin II (concentration of active vitamin B12), atypical and subclinical deficiency states can be recognized. A new approach to diagnosing vitamin B12 deficiency is presented, based upon these 2 case descriptions. SN - 1876-8784 UR - https://www.unboundmedicine.com/medline/citation/22217304/[Approaches_to_vitamin_B12_deficiency]_ L2 - https://www.ntvg.nl/A3595 DB - PRIME DP - Unbound Medicine ER -