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Dietary intake of folate and alcohol, MTHFR C677T polymorphism, and colorectal cancer risk in Korea.
Am J Clin Nutr 2012; 95(2):405-12AJ

Abstract

BACKGROUND

The incidence of colorectal cancer (CRC) is increasing sharply in Korea, and evidence has suggested the role of dietary methyl supply and related polymorphisms on colorectal carcinogenesis.

OBJECTIVE

We investigated the association between folate and alcohol intake, methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, and CRC risk in Koreans.

DESIGN

A total of 787 cases and 656 controls were recruited from 2 university hospitals. Multiple logistic regression models were used to estimate ORs and corresponding 95% CIs.

RESULTS

MTHFR 677T homozygotes were at a lower risk of CRC (OR: 0.60; 95% CI: 0.46, 0.78 for TT compared with CC/CT). High folate intake was associated with reduced CRC risk (OR: 0.64; 95% CI: 0.49, 0.84 for high compared with low intake), and high alcohol consumption was associated with increased risk of CRC (OR: 1.76; 95% CI: 1.26, 2.46 for high compared with low intake). When data were stratified by the amount of dietary methyl (combined intake of folate and alcohol), those with low-methyl diets had higher risk of CRC (OR: 2.32; 95% CI: 1.18, 4.56) than did those with high-methyl diets among CC/CT carriers, whereas the amount of dietary methyl did not affect the CRC risk among carriers with the TT homozygous variant. This association was stronger in patients with colon cancer than in patients with rectal cancer.

CONCLUSION

We found that the effect of dietary methyl supply on colorectal carcinogenesis may differ according to MTHFR C677T genotype and the subsite of origin in a Korean population.

Authors+Show Affiliations

Cancer Epidemiology Branch, National Cancer Center, Goyang, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22218157

Citation

Kim, Jeongseon, et al. "Dietary Intake of Folate and Alcohol, MTHFR C677T Polymorphism, and Colorectal Cancer Risk in Korea." The American Journal of Clinical Nutrition, vol. 95, no. 2, 2012, pp. 405-12.
Kim J, Cho YA, Kim DH, et al. Dietary intake of folate and alcohol, MTHFR C677T polymorphism, and colorectal cancer risk in Korea. Am J Clin Nutr. 2012;95(2):405-12.
Kim, J., Cho, Y. A., Kim, D. H., Lee, B. H., Hwang, D. Y., Jeong, J., ... Ahn, Y. O. (2012). Dietary intake of folate and alcohol, MTHFR C677T polymorphism, and colorectal cancer risk in Korea. The American Journal of Clinical Nutrition, 95(2), pp. 405-12. doi:10.3945/ajcn.111.020255.
Kim J, et al. Dietary Intake of Folate and Alcohol, MTHFR C677T Polymorphism, and Colorectal Cancer Risk in Korea. Am J Clin Nutr. 2012;95(2):405-12. PubMed PMID: 22218157.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of folate and alcohol, MTHFR C677T polymorphism, and colorectal cancer risk in Korea. AU - Kim,Jeongseon, AU - Cho,Young Ae, AU - Kim,Dong-Hyun, AU - Lee,Bong-Hwa, AU - Hwang,Dae-Yong, AU - Jeong,Jinyoung, AU - Lee,Hun-Jae, AU - Matsuo,Keitaro, AU - Tajima,Kazuo, AU - Ahn,Yoon-Ok, Y1 - 2012/01/04/ PY - 2012/1/6/entrez PY - 2012/1/6/pubmed PY - 2012/3/7/medline SP - 405 EP - 12 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 95 IS - 2 N2 - BACKGROUND: The incidence of colorectal cancer (CRC) is increasing sharply in Korea, and evidence has suggested the role of dietary methyl supply and related polymorphisms on colorectal carcinogenesis. OBJECTIVE: We investigated the association between folate and alcohol intake, methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, and CRC risk in Koreans. DESIGN: A total of 787 cases and 656 controls were recruited from 2 university hospitals. Multiple logistic regression models were used to estimate ORs and corresponding 95% CIs. RESULTS: MTHFR 677T homozygotes were at a lower risk of CRC (OR: 0.60; 95% CI: 0.46, 0.78 for TT compared with CC/CT). High folate intake was associated with reduced CRC risk (OR: 0.64; 95% CI: 0.49, 0.84 for high compared with low intake), and high alcohol consumption was associated with increased risk of CRC (OR: 1.76; 95% CI: 1.26, 2.46 for high compared with low intake). When data were stratified by the amount of dietary methyl (combined intake of folate and alcohol), those with low-methyl diets had higher risk of CRC (OR: 2.32; 95% CI: 1.18, 4.56) than did those with high-methyl diets among CC/CT carriers, whereas the amount of dietary methyl did not affect the CRC risk among carriers with the TT homozygous variant. This association was stronger in patients with colon cancer than in patients with rectal cancer. CONCLUSION: We found that the effect of dietary methyl supply on colorectal carcinogenesis may differ according to MTHFR C677T genotype and the subsite of origin in a Korean population. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22218157/Dietary_intake_of_folate_and_alcohol_MTHFR_C677T_polymorphism_and_colorectal_cancer_risk_in_Korea_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.020255 DB - PRIME DP - Unbound Medicine ER -