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Racial differences in restless legs symptoms and serum ferritin in an incident dialysis patient cohort.
Int Urol Nephrol 2012; 44(6):1825-31IU

Abstract

PURPOSE

Restless legs syndrome (RLS), a debilitating sleep disorder that is frequently reported by CKD patients on dialysis, may be more common in whites than in non-whites. Iron deficiency is associated with RLS, and serum ferritin is higher among African Americans compared to Caucasians in the general population. No prior studies have compared restless legs symptoms and serum ferritin levels of African-American and those of the Caucasian patients on dialysis.

METHODS

In a multicenter observational study that included in-person interviews and medical chart review, we studied 210 patients who had recently started renal dialysis. Predictors of restless legs symptoms were examined in a multivariable logistic regression model.

RESULTS

African Americans had a reduced risk of restless legs complaint compared to Caucasian patients (OR, 0.44 [95% CI 0.21-0.93]; P=0.03). African-American patients were also less likely than Caucasian patients to have low serum ferritin values (<100 ng/ml), and among patients with serum ferritin≥100 ng/ml, the average serum ferritin of African-American patients was higher than that of Caucasian patients.

CONCLUSIONS

Further study of racial and iron status relationships could advance the understanding of RLS pathophysiology, and RLS is an important patient outcome to monitor, as revised anemia and iron protocols are implemented in the clinical setting.

Authors+Show Affiliations

Department of Rehabilitation Medicine, School of Medicine, Emory University, CRM-1441 Clifton Rd. N.E., Atlanta, GA 30322, USA. nkutner@emory.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22219175

Citation

Kutner, Nancy G., et al. "Racial Differences in Restless Legs Symptoms and Serum Ferritin in an Incident Dialysis Patient Cohort." International Urology and Nephrology, vol. 44, no. 6, 2012, pp. 1825-31.
Kutner NG, Zhang R, Huang Y, et al. Racial differences in restless legs symptoms and serum ferritin in an incident dialysis patient cohort. Int Urol Nephrol. 2012;44(6):1825-31.
Kutner, N. G., Zhang, R., Huang, Y., & Bliwise, D. L. (2012). Racial differences in restless legs symptoms and serum ferritin in an incident dialysis patient cohort. International Urology and Nephrology, 44(6), pp. 1825-31. doi:10.1007/s11255-011-0108-6.
Kutner NG, et al. Racial Differences in Restless Legs Symptoms and Serum Ferritin in an Incident Dialysis Patient Cohort. Int Urol Nephrol. 2012;44(6):1825-31. PubMed PMID: 22219175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Racial differences in restless legs symptoms and serum ferritin in an incident dialysis patient cohort. AU - Kutner,Nancy G, AU - Zhang,Rebecca, AU - Huang,Yijian, AU - Bliwise,Donald L, Y1 - 2012/01/05/ PY - 2011/10/15/received PY - 2011/12/16/accepted PY - 2012/1/6/entrez PY - 2012/1/6/pubmed PY - 2013/5/15/medline SP - 1825 EP - 31 JF - International urology and nephrology JO - Int Urol Nephrol VL - 44 IS - 6 N2 - PURPOSE: Restless legs syndrome (RLS), a debilitating sleep disorder that is frequently reported by CKD patients on dialysis, may be more common in whites than in non-whites. Iron deficiency is associated with RLS, and serum ferritin is higher among African Americans compared to Caucasians in the general population. No prior studies have compared restless legs symptoms and serum ferritin levels of African-American and those of the Caucasian patients on dialysis. METHODS: In a multicenter observational study that included in-person interviews and medical chart review, we studied 210 patients who had recently started renal dialysis. Predictors of restless legs symptoms were examined in a multivariable logistic regression model. RESULTS: African Americans had a reduced risk of restless legs complaint compared to Caucasian patients (OR, 0.44 [95% CI 0.21-0.93]; P=0.03). African-American patients were also less likely than Caucasian patients to have low serum ferritin values (<100 ng/ml), and among patients with serum ferritin≥100 ng/ml, the average serum ferritin of African-American patients was higher than that of Caucasian patients. CONCLUSIONS: Further study of racial and iron status relationships could advance the understanding of RLS pathophysiology, and RLS is an important patient outcome to monitor, as revised anemia and iron protocols are implemented in the clinical setting. SN - 1573-2584 UR - https://www.unboundmedicine.com/medline/citation/22219175/Racial_differences_in_restless_legs_symptoms_and_serum_ferritin_in_an_incident_dialysis_patient_cohort_ L2 - https://doi.org/10.1007/s11255-011-0108-6 DB - PRIME DP - Unbound Medicine ER -