Tags

Type your tag names separated by a space and hit enter

Moderately increased risk of urinary stone disease in patients with biopsy-verified coeliac disease.

Abstract

BACKGROUND

Urinary stone disease is a mal-absorptive disorder that is a significant health problem because of its high prevalence and incidence. However, there are few population-based studies on the risk of urinary stone disease in patients with coeliac disease (CD).

AIM

To examine the risk of urinary stone disease in CD.

METHODS

Population-based cohort study. Using small intestinal biopsy report data from 1969 to 2008 obtained from all Swedish pathology departments (n = 28), we identified 28 735 patients with CD (equal to Marsh 3: villous atrophy). Patients were then matched for gender, age, county and calendar year to 142 177 reference individuals from the Swedish general population. We used Cox regression to estimate hazard ratios (HRs) for future urinary stone disease and conditional logistic regression to calculate odds ratios (ORs) for urinary stone disease before diagnosis of CD. Individuals with urinary stone disease were identified through the Swedish National Patient Register that contains data on inpatient care, outpatient care and day surgery.

RESULTS

During follow-up, 314 individuals with CD and 1142 reference individuals developed urinary stone disease. This corresponded to a 27% increased risk of urinary stone disease in CD [95% confidence interval (CI) = 1.12-1.44]. CD patients had an absolute risk of urinary stone disease of 107/100 000 person-years (excess risk of 23/100 000). Risk estimates were similar in men and women, and did not differ according to age at CD diagnosis. Conditional logistic regression found that patients with CD were at a slightly increased risk also of prior urinary stone disease (OR = 1.19; 95% CI = 1.06-1.33).

CONCLUSION

In this study, coeliac disease was associated with a moderately increased risk of urinary stone disease both before and after coeliac disease diagnosis.

Links

  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Paediatrics, Örebro University Hospital, Örebro, Sweden. jonasludvigsson@yahoo.com

    , , ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Biopsy
    Celiac Disease
    Child
    Child, Preschool
    Cohort Studies
    Female
    Humans
    Infant
    Male
    Middle Aged
    Regression Analysis
    Risk Factors
    Sweden
    Urinary Calculi
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22221254

    Citation

    Ludvigsson, J F., et al. "Moderately Increased Risk of Urinary Stone Disease in Patients With Biopsy-verified Coeliac Disease." Alimentary Pharmacology & Therapeutics, vol. 35, no. 4, 2012, pp. 477-84.
    Ludvigsson JF, Zingone F, Fored M, et al. Moderately increased risk of urinary stone disease in patients with biopsy-verified coeliac disease. Aliment Pharmacol Ther. 2012;35(4):477-84.
    Ludvigsson, J. F., Zingone, F., Fored, M., Ciacci, C., & Cirillo, M. (2012). Moderately increased risk of urinary stone disease in patients with biopsy-verified coeliac disease. Alimentary Pharmacology & Therapeutics, 35(4), pp. 477-84. doi:10.1111/j.1365-2036.2011.04968.x.
    Ludvigsson JF, et al. Moderately Increased Risk of Urinary Stone Disease in Patients With Biopsy-verified Coeliac Disease. Aliment Pharmacol Ther. 2012;35(4):477-84. PubMed PMID: 22221254.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Moderately increased risk of urinary stone disease in patients with biopsy-verified coeliac disease. AU - Ludvigsson,J F, AU - Zingone,F, AU - Fored,M, AU - Ciacci,C, AU - Cirillo,M, Y1 - 2012/01/04/ PY - 2011/10/21/received PY - 2011/11/13/revised PY - 2011/12/09/revised PY - 2011/12/10/accepted PY - 2012/1/7/entrez PY - 2012/1/10/pubmed PY - 2012/4/27/medline SP - 477 EP - 84 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 35 IS - 4 N2 - BACKGROUND: Urinary stone disease is a mal-absorptive disorder that is a significant health problem because of its high prevalence and incidence. However, there are few population-based studies on the risk of urinary stone disease in patients with coeliac disease (CD). AIM: To examine the risk of urinary stone disease in CD. METHODS: Population-based cohort study. Using small intestinal biopsy report data from 1969 to 2008 obtained from all Swedish pathology departments (n = 28), we identified 28 735 patients with CD (equal to Marsh 3: villous atrophy). Patients were then matched for gender, age, county and calendar year to 142 177 reference individuals from the Swedish general population. We used Cox regression to estimate hazard ratios (HRs) for future urinary stone disease and conditional logistic regression to calculate odds ratios (ORs) for urinary stone disease before diagnosis of CD. Individuals with urinary stone disease were identified through the Swedish National Patient Register that contains data on inpatient care, outpatient care and day surgery. RESULTS: During follow-up, 314 individuals with CD and 1142 reference individuals developed urinary stone disease. This corresponded to a 27% increased risk of urinary stone disease in CD [95% confidence interval (CI) = 1.12-1.44]. CD patients had an absolute risk of urinary stone disease of 107/100 000 person-years (excess risk of 23/100 000). Risk estimates were similar in men and women, and did not differ according to age at CD diagnosis. Conditional logistic regression found that patients with CD were at a slightly increased risk also of prior urinary stone disease (OR = 1.19; 95% CI = 1.06-1.33). CONCLUSION: In this study, coeliac disease was associated with a moderately increased risk of urinary stone disease both before and after coeliac disease diagnosis. SN - 1365-2036 UR - https://www.unboundmedicine.com/medline/citation/22221254/Moderately_increased_risk_of_urinary_stone_disease_in_patients_with_biopsy_verified_coeliac_disease_ L2 - https://doi.org/10.1111/j.1365-2036.2011.04968.x DB - PRIME DP - Unbound Medicine ER -