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Associations between phthalate metabolite urinary concentrations and body size measures in New York City children.
Environ Res. 2012 Jan; 112:186-93.ER

Abstract

OBJECTIVE

To examine prospectively associations between urinary phthalate metabolite concentrations and body size measures in children.

METHODS

Urinary concentrations of nine phthalate metabolites: monoethyl (MEP); mono-n-butyl (MBP); mono-(3-carboxypropyl) (MCPP); monobenzyl (MBzP); mono-isobutyl (MiBP); mono-(2-ethylhexyl) (MEHP); mono-(2-ethyl-5-oxohexyl) (MEOHP); mono-(2-ethyl-5-carboxypentyl) (MECPP); and mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and the molar sum of the low molecular-weight phthalate metabolites (low MWP: MEP, MBP and MiBP) and high molecular-weight phthalate metabolites (high MWP: MECPP, MEHHP, MEOHP, MEHP and MBzP) and of four di-(2-ethylhexyl) phthalate (DEHP) metabolites (ΣDEHP: MEHP, MEHHP, MEOHP, MECPP) and anthropometry, including body mass index and waist circumference were measured among 387 Hispanic and Black, New York City children who were between six and eight years at cohort enrollment (2004-2007). Relationships between baseline metabolite concentrations and body size characteristics obtained one year later were examined using multivariate-adjusted geometric means for each body size characteristic by continuous and categories of phthalate metabolite concentrations. Stratified analyses by body size (age/sex specific) were conducted.

RESULTS

No significant associations are reported among all girls or boys. Dose response relationships were seen with monoethyl phthalate and the sum of low molecular-weight phthalates and body mass index and waist circumference among overweight children; for increasing monoethyl phthalate concentration quartiles among girls, adjusted mean body mass indexes were as follows: 21.3, 21.7, 23.8, 23.5 and adjusted mean waist circumference (cm) were as follows: 73.4, 73.5, 79.2, 78.8 (p-trend<0.001 for both).

CONCLUSION

In this prospective analysis we identified positive relationships between urinary concentrations of monoethyl phthalate and the sum of low molecular-weight phthalates and body size measures in overweight children. These are metabolites with concentrations above 1 μM.

Authors+Show Affiliations

Mount Sinai School of Medicine, Department of Preventive Medicine, One Gustave L. Levy Place, Box 1057, NY 10029, USA. Susan.Teitelbaum@mssm.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

22222007

Citation

Teitelbaum, Susan L., et al. "Associations Between Phthalate Metabolite Urinary Concentrations and Body Size Measures in New York City Children." Environmental Research, vol. 112, 2012, pp. 186-93.
Teitelbaum SL, Mervish N, Moshier EL, et al. Associations between phthalate metabolite urinary concentrations and body size measures in New York City children. Environ Res. 2012;112:186-93.
Teitelbaum, S. L., Mervish, N., Moshier, E. L., Vangeepuram, N., Galvez, M. P., Calafat, A. M., Silva, M. J., Brenner, B. L., & Wolff, M. S. (2012). Associations between phthalate metabolite urinary concentrations and body size measures in New York City children. Environmental Research, 112, 186-93. https://doi.org/10.1016/j.envres.2011.12.006
Teitelbaum SL, et al. Associations Between Phthalate Metabolite Urinary Concentrations and Body Size Measures in New York City Children. Environ Res. 2012;112:186-93. PubMed PMID: 22222007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations between phthalate metabolite urinary concentrations and body size measures in New York City children. AU - Teitelbaum,Susan L, AU - Mervish,Nancy, AU - Moshier,Erin L, AU - Vangeepuram,Nita, AU - Galvez,Maida P, AU - Calafat,Antonia M, AU - Silva,Manori J, AU - Brenner,Barbara L, AU - Wolff,Mary S, Y1 - 2012/01/04/ PY - 2011/05/18/received PY - 2011/11/28/revised PY - 2011/12/12/accepted PY - 2012/1/7/entrez PY - 2012/1/10/pubmed PY - 2012/3/20/medline SP - 186 EP - 93 JF - Environmental research JO - Environ Res VL - 112 N2 - OBJECTIVE: To examine prospectively associations between urinary phthalate metabolite concentrations and body size measures in children. METHODS: Urinary concentrations of nine phthalate metabolites: monoethyl (MEP); mono-n-butyl (MBP); mono-(3-carboxypropyl) (MCPP); monobenzyl (MBzP); mono-isobutyl (MiBP); mono-(2-ethylhexyl) (MEHP); mono-(2-ethyl-5-oxohexyl) (MEOHP); mono-(2-ethyl-5-carboxypentyl) (MECPP); and mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and the molar sum of the low molecular-weight phthalate metabolites (low MWP: MEP, MBP and MiBP) and high molecular-weight phthalate metabolites (high MWP: MECPP, MEHHP, MEOHP, MEHP and MBzP) and of four di-(2-ethylhexyl) phthalate (DEHP) metabolites (ΣDEHP: MEHP, MEHHP, MEOHP, MECPP) and anthropometry, including body mass index and waist circumference were measured among 387 Hispanic and Black, New York City children who were between six and eight years at cohort enrollment (2004-2007). Relationships between baseline metabolite concentrations and body size characteristics obtained one year later were examined using multivariate-adjusted geometric means for each body size characteristic by continuous and categories of phthalate metabolite concentrations. Stratified analyses by body size (age/sex specific) were conducted. RESULTS: No significant associations are reported among all girls or boys. Dose response relationships were seen with monoethyl phthalate and the sum of low molecular-weight phthalates and body mass index and waist circumference among overweight children; for increasing monoethyl phthalate concentration quartiles among girls, adjusted mean body mass indexes were as follows: 21.3, 21.7, 23.8, 23.5 and adjusted mean waist circumference (cm) were as follows: 73.4, 73.5, 79.2, 78.8 (p-trend<0.001 for both). CONCLUSION: In this prospective analysis we identified positive relationships between urinary concentrations of monoethyl phthalate and the sum of low molecular-weight phthalates and body size measures in overweight children. These are metabolites with concentrations above 1 μM. SN - 1096-0953 UR - https://www.unboundmedicine.com/medline/citation/22222007/Associations_between_phthalate_metabolite_urinary_concentrations_and_body_size_measures_in_New_York_City_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(11)00311-2 DB - PRIME DP - Unbound Medicine ER -