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Lack of airway response to nasal irritation in normal and asthmatic subjects.
Aust N Z J Med 1990; 20(4):578-82AN

Abstract

Twenty two subjects (10 normals, nine asthmatics and three who had suggestive histories for asthma but normal bronchial histamine challenges) underwent nasal challenges with logarithmic incremental doses of histamine or saline on alternate days. Nasal resistance (measured by posterior rhinometry), and forced expiratory volume in one second (FEV1) were assessed after each dose of nasal histamine or placebo. After each nasal challenge (maximum nasal dose of 250 micrograms of histamine or doubling of nasal resistance) bronchial responsiveness was measured with a bronchial histamine challenge. Despite significant changes in nasal resistance with nasal histamine (p less than 0.01) there was no significant change in the forced expiratory volume in one second, or in bronchial responsiveness. We were unable to demonstrate nasobronchial reflexes initiated by acute irritation of the nasal mucosa with histamine in either normal subjects or in those with mild to moderate asthma.

Authors+Show Affiliations

Department of Thoracic Medicine, Royal Newcastle Hospital, NSW.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2222351

Citation

Levi, C R., et al. "Lack of Airway Response to Nasal Irritation in Normal and Asthmatic Subjects." Australian and New Zealand Journal of Medicine, vol. 20, no. 4, 1990, pp. 578-82.
Levi CR, Tyler GR, Olson LG, et al. Lack of airway response to nasal irritation in normal and asthmatic subjects. Aust N Z J Med. 1990;20(4):578-82.
Levi, C. R., Tyler, G. R., Olson, L. G., & Saunders, N. A. (1990). Lack of airway response to nasal irritation in normal and asthmatic subjects. Australian and New Zealand Journal of Medicine, 20(4), pp. 578-82.
Levi CR, et al. Lack of Airway Response to Nasal Irritation in Normal and Asthmatic Subjects. Aust N Z J Med. 1990;20(4):578-82. PubMed PMID: 2222351.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of airway response to nasal irritation in normal and asthmatic subjects. AU - Levi,C R, AU - Tyler,G R, AU - Olson,L G, AU - Saunders,N A, PY - 1990/8/1/pubmed PY - 1990/8/1/medline PY - 1990/8/1/entrez SP - 578 EP - 82 JF - Australian and New Zealand journal of medicine JO - Aust N Z J Med VL - 20 IS - 4 N2 - Twenty two subjects (10 normals, nine asthmatics and three who had suggestive histories for asthma but normal bronchial histamine challenges) underwent nasal challenges with logarithmic incremental doses of histamine or saline on alternate days. Nasal resistance (measured by posterior rhinometry), and forced expiratory volume in one second (FEV1) were assessed after each dose of nasal histamine or placebo. After each nasal challenge (maximum nasal dose of 250 micrograms of histamine or doubling of nasal resistance) bronchial responsiveness was measured with a bronchial histamine challenge. Despite significant changes in nasal resistance with nasal histamine (p less than 0.01) there was no significant change in the forced expiratory volume in one second, or in bronchial responsiveness. We were unable to demonstrate nasobronchial reflexes initiated by acute irritation of the nasal mucosa with histamine in either normal subjects or in those with mild to moderate asthma. SN - 0004-8291 UR - https://www.unboundmedicine.com/medline/citation/2222351/Lack_of_airway_response_to_nasal_irritation_in_normal_and_asthmatic_subjects_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0004-8291&date=1990&volume=20&issue=4&spage=578 DB - PRIME DP - Unbound Medicine ER -