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Tomato-based food products are related to clinically modest improvements in selected coronary biomarkers in women.
J Nutr. 2012 Feb; 142(2):326-33.JN

Abstract

Few epidemiologic studies have examined the potential cardiovascular mechanisms of tomato-based food products, the primary dietary source of lycopene. We examined the cross-sectional association between tomato-based food product intake and coronary biomarkers in the Women's Health Study. Tomato-based food products (tomatoes, tomato juice, tomato sauce, pizza) were summed from a semiquantitative FFQ and multiple risk factors ascertained. Plasma from baseline blood samples were assayed for lipids, lipoproteins, hemoglobin A1c, C-reactive protein, fibrinogen, soluble intracellular adhesion molecule-1, and creatinine. A total of 27,261 women aged ≥45 y who were free of cardiovascular disease and cancer provided relevant data for this study. Tomato-based food product intake was modest, with 84% of women consuming <1 serving/d, but those with greater intake had healthier lifestyle and dietary habits. Women consuming ≥10 compared with <1.5 servings/wk of tomato-based food products had significant but clinically modest improvements in total cholesterol (TC) (5.38 vs. 5.51 mmol/L; P = 0.029), the TC:HDL cholesterol ratio (4.08 vs. 4.22; P = 0.046), and hemoglobin A1c (5.02 vs. 5.13%; P < 0.001) in multivariable models. Considering clinical cutpoints, women consuming ≥10 compared with <1.5 servings/wk were 31% (95% CI = 6%, 50%), 40% (95% CI = 13%, 59%), and 66% (95% CI = 20%, 86%) less likely to have elevated TC (≥6.21 mmol/L), LDL cholesterol (≥4.14 mmol/L), and hemoglobin A1c (≥6%), respectively. Other coronary biomarkers were unassociated with tomato-based food products. In conclusion, women consuming ≥10 compared with <1.5 servings/wk of tomato-based food products had clinically modest but significant improvements in TC, the TC:HDL cholesterol ratio, and hemoglobin A1c but not other coronary biomarkers.

Authors+Show Affiliations

Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA. hsesso@hsph.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22223578

Citation

Sesso, Howard D., et al. "Tomato-based Food Products Are Related to Clinically Modest Improvements in Selected Coronary Biomarkers in Women." The Journal of Nutrition, vol. 142, no. 2, 2012, pp. 326-33.
Sesso HD, Wang L, Ridker PM, et al. Tomato-based food products are related to clinically modest improvements in selected coronary biomarkers in women. J Nutr. 2012;142(2):326-33.
Sesso, H. D., Wang, L., Ridker, P. M., & Buring, J. E. (2012). Tomato-based food products are related to clinically modest improvements in selected coronary biomarkers in women. The Journal of Nutrition, 142(2), 326-33. https://doi.org/10.3945/jn.111.150631
Sesso HD, et al. Tomato-based Food Products Are Related to Clinically Modest Improvements in Selected Coronary Biomarkers in Women. J Nutr. 2012;142(2):326-33. PubMed PMID: 22223578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tomato-based food products are related to clinically modest improvements in selected coronary biomarkers in women. AU - Sesso,Howard D, AU - Wang,Lu, AU - Ridker,Paul M, AU - Buring,Julie E, Y1 - 2012/01/05/ PY - 2012/1/7/entrez PY - 2012/1/10/pubmed PY - 2012/3/27/medline SP - 326 EP - 33 JF - The Journal of nutrition JO - J. Nutr. VL - 142 IS - 2 N2 - Few epidemiologic studies have examined the potential cardiovascular mechanisms of tomato-based food products, the primary dietary source of lycopene. We examined the cross-sectional association between tomato-based food product intake and coronary biomarkers in the Women's Health Study. Tomato-based food products (tomatoes, tomato juice, tomato sauce, pizza) were summed from a semiquantitative FFQ and multiple risk factors ascertained. Plasma from baseline blood samples were assayed for lipids, lipoproteins, hemoglobin A1c, C-reactive protein, fibrinogen, soluble intracellular adhesion molecule-1, and creatinine. A total of 27,261 women aged ≥45 y who were free of cardiovascular disease and cancer provided relevant data for this study. Tomato-based food product intake was modest, with 84% of women consuming <1 serving/d, but those with greater intake had healthier lifestyle and dietary habits. Women consuming ≥10 compared with <1.5 servings/wk of tomato-based food products had significant but clinically modest improvements in total cholesterol (TC) (5.38 vs. 5.51 mmol/L; P = 0.029), the TC:HDL cholesterol ratio (4.08 vs. 4.22; P = 0.046), and hemoglobin A1c (5.02 vs. 5.13%; P < 0.001) in multivariable models. Considering clinical cutpoints, women consuming ≥10 compared with <1.5 servings/wk were 31% (95% CI = 6%, 50%), 40% (95% CI = 13%, 59%), and 66% (95% CI = 20%, 86%) less likely to have elevated TC (≥6.21 mmol/L), LDL cholesterol (≥4.14 mmol/L), and hemoglobin A1c (≥6%), respectively. Other coronary biomarkers were unassociated with tomato-based food products. In conclusion, women consuming ≥10 compared with <1.5 servings/wk of tomato-based food products had clinically modest but significant improvements in TC, the TC:HDL cholesterol ratio, and hemoglobin A1c but not other coronary biomarkers. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/22223578/Tomato_based_food_products_are_related_to_clinically_modest_improvements_in_selected_coronary_biomarkers_in_women_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.111.150631 DB - PRIME DP - Unbound Medicine ER -