Tags

Type your tag names separated by a space and hit enter

Uncoordinated regulation of atrial natriuretic factor and brain natriuretic peptide in lipopolysaccharide-treated rats.
Biomarkers. 2012 Mar; 17(2):140-9.B

Abstract

We investigated the expression and secretion of the natriuretic peptides (NPs) ANF and BNP in lipopolysaccharide (LPS)-induced sepsis and its association with cytokines and other biologically active substances. LPS treatment increased plasma levels of ANF and BNP. The latter increase was larger than the increase in plasma ANF. LPS also increased cardiac content and gene expression of BNP but not of ANF. LPS treatment significantly increased gene expression cytokines, chemokines and proteases, which significantly correlated with BNP gene expression. SB203580, a p38 MAP kinase inhibitor, inhibited the elevation of BNP in plasma. The present work suggests that during inflammation, BNP gene expression and secretion is uniquely related to changes in gene expression in the absence of hemodynamic changes and hence differentiates ANF and BNP as biomarkers of cardiac disease.

Authors+Show Affiliations

Cardiovascular Endocrinology Laboratory, University of Ottawa Heart Institute, Ottawa, Canada.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22224641

Citation

Ogawa, Tsuneo, and Adolfo J. de Bold. "Uncoordinated Regulation of Atrial Natriuretic Factor and Brain Natriuretic Peptide in Lipopolysaccharide-treated Rats." Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals, vol. 17, no. 2, 2012, pp. 140-9.
Ogawa T, de Bold AJ. Uncoordinated regulation of atrial natriuretic factor and brain natriuretic peptide in lipopolysaccharide-treated rats. Biomarkers. 2012;17(2):140-9.
Ogawa, T., & de Bold, A. J. (2012). Uncoordinated regulation of atrial natriuretic factor and brain natriuretic peptide in lipopolysaccharide-treated rats. Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals, 17(2), 140-9. https://doi.org/10.3109/1354750X.2011.643487
Ogawa T, de Bold AJ. Uncoordinated Regulation of Atrial Natriuretic Factor and Brain Natriuretic Peptide in Lipopolysaccharide-treated Rats. Biomarkers. 2012;17(2):140-9. PubMed PMID: 22224641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Uncoordinated regulation of atrial natriuretic factor and brain natriuretic peptide in lipopolysaccharide-treated rats. AU - Ogawa,Tsuneo, AU - de Bold,Adolfo J, Y1 - 2012/01/06/ PY - 2012/1/10/entrez PY - 2012/1/10/pubmed PY - 2012/7/24/medline SP - 140 EP - 9 JF - Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals JO - Biomarkers VL - 17 IS - 2 N2 - We investigated the expression and secretion of the natriuretic peptides (NPs) ANF and BNP in lipopolysaccharide (LPS)-induced sepsis and its association with cytokines and other biologically active substances. LPS treatment increased plasma levels of ANF and BNP. The latter increase was larger than the increase in plasma ANF. LPS also increased cardiac content and gene expression of BNP but not of ANF. LPS treatment significantly increased gene expression cytokines, chemokines and proteases, which significantly correlated with BNP gene expression. SB203580, a p38 MAP kinase inhibitor, inhibited the elevation of BNP in plasma. The present work suggests that during inflammation, BNP gene expression and secretion is uniquely related to changes in gene expression in the absence of hemodynamic changes and hence differentiates ANF and BNP as biomarkers of cardiac disease. SN - 1366-5804 UR - https://www.unboundmedicine.com/medline/citation/22224641/Uncoordinated_regulation_of_atrial_natriuretic_factor_and_brain_natriuretic_peptide_in_lipopolysaccharide_treated_rats_ L2 - https://www.tandfonline.com/doi/full/10.3109/1354750X.2011.643487 DB - PRIME DP - Unbound Medicine ER -