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In end stage osteoarthritis, cartilage tissue pentosidine levels are inversely related to parameters of cartilage damage.
Osteoarthritis Cartilage 2012; 20(3):233-40OC

Abstract

OBJECTIVES

Age is the most prominent predisposition for development of osteoarthritis (OA). Age-related changes of articular cartilage are likely to play a role. Advanced glycation endproducts (AGEs) accumulate in cartilage matrix with increasing age and adversely affect the biomechanical properties of the cartilage matrix and influence chondrocyte activity. In clinical studies AGEing of cartilage and its relation to actual cartilage damage can only be measured by surrogate markers (e.g., serum, skin or urine AGE levels and imaging or biochemical markers of cartilage damage). In this study actual cartilage AGE levels were directly related to actual cartilage damage by use of cartilage obtained at joint replacement surgery.

METHODS

Cartilage and urine samples were obtained from 69 patients undergoing total knee replacement. Samples were analyzed for pentosidine as marker of AGE. Cartilage damage was evaluated macroscopically, histologically, and biochemically.

RESULTS

Cartilage and urine pentosidine both increased with increasing age. The higher the macroscopic, histological, and biochemical cartilage damage the lower the cartilage pentosidine levels were. In multiple regression analysis age is not found to be a confounder.

CONCLUSION

There is an inverse relation between cartilage AGEs and actual cartilage damage in end-stage OA. This is likely due to ongoing (ineffective) increased turnover of cartilage matrix proteins even in end stage disease.

Authors+Show Affiliations

Rheumatology & Clinical Immunology, University Medical Centre Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22227209

Citation

Vos, P A J M., et al. "In End Stage Osteoarthritis, Cartilage Tissue Pentosidine Levels Are Inversely Related to Parameters of Cartilage Damage." Osteoarthritis and Cartilage, vol. 20, no. 3, 2012, pp. 233-40.
Vos PA, Mastbergen SC, Huisman AM, et al. In end stage osteoarthritis, cartilage tissue pentosidine levels are inversely related to parameters of cartilage damage. Osteoarthr Cartil. 2012;20(3):233-40.
Vos, P. A., Mastbergen, S. C., Huisman, A. M., de Boer, T. N., DeGroot, J., Polak, A. A., & Lafeber, F. P. (2012). In end stage osteoarthritis, cartilage tissue pentosidine levels are inversely related to parameters of cartilage damage. Osteoarthritis and Cartilage, 20(3), pp. 233-40. doi:10.1016/j.joca.2011.12.007.
Vos PA, et al. In End Stage Osteoarthritis, Cartilage Tissue Pentosidine Levels Are Inversely Related to Parameters of Cartilage Damage. Osteoarthr Cartil. 2012;20(3):233-40. PubMed PMID: 22227209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In end stage osteoarthritis, cartilage tissue pentosidine levels are inversely related to parameters of cartilage damage. AU - Vos,P A J M, AU - Mastbergen,S C, AU - Huisman,A M, AU - de Boer,T N, AU - DeGroot,J, AU - Polak,A A, AU - Lafeber,F P J G, Y1 - 2011/12/21/ PY - 2011/08/03/received PY - 2011/12/05/revised PY - 2011/12/15/accepted PY - 2012/1/10/entrez PY - 2012/1/10/pubmed PY - 2012/5/1/medline SP - 233 EP - 40 JF - Osteoarthritis and cartilage JO - Osteoarthr. Cartil. VL - 20 IS - 3 N2 - OBJECTIVES: Age is the most prominent predisposition for development of osteoarthritis (OA). Age-related changes of articular cartilage are likely to play a role. Advanced glycation endproducts (AGEs) accumulate in cartilage matrix with increasing age and adversely affect the biomechanical properties of the cartilage matrix and influence chondrocyte activity. In clinical studies AGEing of cartilage and its relation to actual cartilage damage can only be measured by surrogate markers (e.g., serum, skin or urine AGE levels and imaging or biochemical markers of cartilage damage). In this study actual cartilage AGE levels were directly related to actual cartilage damage by use of cartilage obtained at joint replacement surgery. METHODS: Cartilage and urine samples were obtained from 69 patients undergoing total knee replacement. Samples were analyzed for pentosidine as marker of AGE. Cartilage damage was evaluated macroscopically, histologically, and biochemically. RESULTS: Cartilage and urine pentosidine both increased with increasing age. The higher the macroscopic, histological, and biochemical cartilage damage the lower the cartilage pentosidine levels were. In multiple regression analysis age is not found to be a confounder. CONCLUSION: There is an inverse relation between cartilage AGEs and actual cartilage damage in end-stage OA. This is likely due to ongoing (ineffective) increased turnover of cartilage matrix proteins even in end stage disease. SN - 1522-9653 UR - https://www.unboundmedicine.com/medline/citation/22227209/In_end_stage_osteoarthritis_cartilage_tissue_pentosidine_levels_are_inversely_related_to_parameters_of_cartilage_damage_ L2 - http://linkinghub.elsevier.com/retrieve/pii/S1063-4584(11)00349-9 DB - PRIME DP - Unbound Medicine ER -