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[Pathogenetic factors of hemorrhage from esophageal varices].
Gastroenterol J. 1990; 50(2):60-4.GJ

Abstract

Esophageal varices nearly always rupture at or just above the gastro-esophageal junction. Mucosal changes on top of the varices, the so-called red colour sign, are found in the majority of patients with a positive bleeding history. An increase of intraabdominal pressure and consequently a sudden pressure rise in the varices is thought of as a trigger cause. The larger the esophageal varices the higher the intravariceal and the transmural varix pressures. The portal pressure in patients with portal hypertension is subjected to considerable changes. Therefore, hemodynamic measurements at rest may have a prognostic value with regard to predisposition to hemorrhage, but they are less significant than endoscopic parameters. Disturbances of blood hemostasis and ascites indicating an impaired liver function are essential predisponable factors for the onset of bleedings. A peptic lesion caused by acid gastric-esophageal reflux is of less importance for the occurrence of variceal hemorrhage.

Authors+Show Affiliations

Kobe E
Klinik für Innere Medizin, Medizinischen Akademie, Carl Gustav Carus Dresden.

MeSH

Esophageal and Gastric VaricesEsophagogastric JunctionGastrointestinal HemorrhageHumansHypertension, PortalMuscle, Smooth, VascularRisk FactorsRupture, SpontaneousVenous Pressure

Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

2222784

Citation

Kobe, E. "[Pathogenetic Factors of Hemorrhage From Esophageal Varices]." Gastroenterologisches Journal : Organ Der Gesellschaft Fur Gastroenterologie Der DDR, vol. 50, no. 2, 1990, pp. 60-4.
Kobe E. [Pathogenetic factors of hemorrhage from esophageal varices]. Gastroenterol J. 1990;50(2):60-4.
Kobe, E. (1990). [Pathogenetic factors of hemorrhage from esophageal varices]. Gastroenterologisches Journal : Organ Der Gesellschaft Fur Gastroenterologie Der DDR, 50(2), 60-4.
Kobe E. [Pathogenetic Factors of Hemorrhage From Esophageal Varices]. Gastroenterol J. 1990;50(2):60-4. PubMed PMID: 2222784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Pathogenetic factors of hemorrhage from esophageal varices]. A1 - Kobe,E, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 60 EP - 4 JF - Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR JO - Gastroenterol J VL - 50 IS - 2 N2 - Esophageal varices nearly always rupture at or just above the gastro-esophageal junction. Mucosal changes on top of the varices, the so-called red colour sign, are found in the majority of patients with a positive bleeding history. An increase of intraabdominal pressure and consequently a sudden pressure rise in the varices is thought of as a trigger cause. The larger the esophageal varices the higher the intravariceal and the transmural varix pressures. The portal pressure in patients with portal hypertension is subjected to considerable changes. Therefore, hemodynamic measurements at rest may have a prognostic value with regard to predisposition to hemorrhage, but they are less significant than endoscopic parameters. Disturbances of blood hemostasis and ascites indicating an impaired liver function are essential predisponable factors for the onset of bleedings. A peptic lesion caused by acid gastric-esophageal reflux is of less importance for the occurrence of variceal hemorrhage. SN - 0863-1743 UR - https://www.unboundmedicine.com/medline/citation/2222784/[Pathogenetic_factors_of_hemorrhage_from_esophageal_varices]_ DB - PRIME DP - Unbound Medicine ER -