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Effects of microcystin-containing cyanobacterial extract on hematological and biochemical parameters of common carp (Cyprinus carpio L.).
Fish Physiol Biochem. 2012 Aug; 38(4):1159-1167.FP

Abstract

The aim of the study was to assess the effects of a cyanobacterial extract containing microcystins (MCs) on selected hematological and biochemical parameters in common carp (Cyprinus carpio L.), as well as to determine the accumulation of toxins in fish tissues. The fish were immersed for 5 days in water containing toxins at a final concentration of 12 μg/L of microcystin LR equivalent. Microcystin LR residues were detected in fish liver, reaching 207, 238 and 260 ng/g f.w. of the tissues taken 24 h, 72 h and 5 days after the end of intoxication, respectively. The most substantial changes were found in fish plasma, including increases in creatine kinase, lactate dehydrogenase, ammonia, glucose, aspartate aminotransferase and alanine aminotransferase levels. A decline of about 50% in lysozyme activity was observed by the end of the experimental period. Moreover, a marked increase in ceruloplasmin activity was detected 24 h after the end of intoxication with a subsequent decrease in its activity after 72 h and 5 days. This study concludes that not only consumption of food containing toxins but also MCs dissolved in water may pose a threat to fish health. Additionally, detected changes in lysozyme and ceruloplasmin activity may have distinct effects in fish resistance against pathogens or oxidative stress, which should be taken into account in the future studies.

Authors+Show Affiliations

Department of Physiology and Ecotoxicology, Institute of Biotechnology, The John Paul II Catholic University of Lublin, ul. Konstantynów 1 H, 20-708, Lublin, Poland. ansie@kul.lublin.pl.Department of Physiology and Ecotoxicology, Institute of Biotechnology, The John Paul II Catholic University of Lublin, ul. Konstantynów 1 H, 20-708, Lublin, Poland.Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Research Institute of Fish Culture and Hydrobiology, University of South Bohemia in Ceske Budejovice, Zatisi 728/II, 389 25, Vodnany, Czech Republic.Polish Academy of Sciences, Centre for Ecological Research, Experimental Station, Niecała 18/3, 20-080, Lublin, Poland.Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Research Institute of Fish Culture and Hydrobiology, University of South Bohemia in Ceske Budejovice, Zatisi 728/II, 389 25, Vodnany, Czech Republic.Department of Physiology and Ecotoxicology, Institute of Biotechnology, The John Paul II Catholic University of Lublin, ul. Konstantynów 1 H, 20-708, Lublin, Poland. Polish Academy of Sciences, Centre for Ecological Research, Experimental Station, Niecała 18/3, 20-080, Lublin, Poland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22228075

Citation

Sieroslawska, Anna, et al. "Effects of Microcystin-containing Cyanobacterial Extract On Hematological and Biochemical Parameters of Common Carp (Cyprinus Carpio L.)." Fish Physiology and Biochemistry, vol. 38, no. 4, 2012, pp. 1159-1167.
Sieroslawska A, Rymuszka A, Velisek J, et al. Effects of microcystin-containing cyanobacterial extract on hematological and biochemical parameters of common carp (Cyprinus carpio L.). Fish Physiol Biochem. 2012;38(4):1159-1167.
Sieroslawska, A., Rymuszka, A., Velisek, J., Pawlik-Skowrońska, B., Svobodova, Z., & Skowroński, T. (2012). Effects of microcystin-containing cyanobacterial extract on hematological and biochemical parameters of common carp (Cyprinus carpio L.). Fish Physiology and Biochemistry, 38(4), 1159-1167. https://doi.org/10.1007/s10695-011-9601-1
Sieroslawska A, et al. Effects of Microcystin-containing Cyanobacterial Extract On Hematological and Biochemical Parameters of Common Carp (Cyprinus Carpio L.). Fish Physiol Biochem. 2012;38(4):1159-1167. PubMed PMID: 22228075.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of microcystin-containing cyanobacterial extract on hematological and biochemical parameters of common carp (Cyprinus carpio L.). AU - Sieroslawska,Anna, AU - Rymuszka,Anna, AU - Velisek,Josef, AU - Pawlik-Skowrońska,Barbara, AU - Svobodova,Zdenka, AU - Skowroński,Tadeusz, Y1 - 2012/01/07/ PY - 2011/06/07/received PY - 2011/12/30/accepted PY - 2012/1/10/entrez PY - 2012/1/10/pubmed PY - 2012/11/9/medline SP - 1159 EP - 1167 JF - Fish physiology and biochemistry JO - Fish Physiol Biochem VL - 38 IS - 4 N2 - The aim of the study was to assess the effects of a cyanobacterial extract containing microcystins (MCs) on selected hematological and biochemical parameters in common carp (Cyprinus carpio L.), as well as to determine the accumulation of toxins in fish tissues. The fish were immersed for 5 days in water containing toxins at a final concentration of 12 μg/L of microcystin LR equivalent. Microcystin LR residues were detected in fish liver, reaching 207, 238 and 260 ng/g f.w. of the tissues taken 24 h, 72 h and 5 days after the end of intoxication, respectively. The most substantial changes were found in fish plasma, including increases in creatine kinase, lactate dehydrogenase, ammonia, glucose, aspartate aminotransferase and alanine aminotransferase levels. A decline of about 50% in lysozyme activity was observed by the end of the experimental period. Moreover, a marked increase in ceruloplasmin activity was detected 24 h after the end of intoxication with a subsequent decrease in its activity after 72 h and 5 days. This study concludes that not only consumption of food containing toxins but also MCs dissolved in water may pose a threat to fish health. Additionally, detected changes in lysozyme and ceruloplasmin activity may have distinct effects in fish resistance against pathogens or oxidative stress, which should be taken into account in the future studies. SN - 1573-5168 UR - https://www.unboundmedicine.com/medline/citation/22228075/Effects_of_microcystin_containing_cyanobacterial_extract_on_hematological_and_biochemical_parameters_of_common_carp__Cyprinus_carpio_L___ L2 - https://dx.doi.org/10.1007/s10695-011-9601-1 DB - PRIME DP - Unbound Medicine ER -