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Expression of vascular endothelial growth factor (VEGF) and its soluble receptor-1 in endometriosis.
Microvasc Res. 2012 Mar; 83(2):237-42.MR

Abstract

The aim of this study is to evaluate the expression of vascular endothelial growth factor (VEGF) and its soluble receptor (sFlt-1) in peritoneal fluid (PF), peritoneal endometriotic lesions and eutopic endometrial tissues of patients with endometriosis. Peritoneal fluid, peritoneal endometriotic lesions and eutopic endometrial samples from patients with endometriosis, and peritoneal fluid, peritoneal tissue and endometrial samples from patients without endometriosis were obtained during an operative laparoscopy. The mean PF concentrations of VEGF and sFlt-1 were significantly higher in patients with endometriosis than in the controls. In the peritoneal tissue, the expressions of VEGF and sFlt-1 were significantly higher, where the expression of sFlt-1 in endometrium was significantly lower in patients with endometriosis. These findings indicate that not only abnormal expressions of angiogenic factors, but also aberrant expressions of antiangiogenic factors in the peritoneal and endometrial environment seem to be involved in the pathogenesis of endometriosis.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University, College of Medicine, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22230112

Citation

Cho, SiHyun, et al. "Expression of Vascular Endothelial Growth Factor (VEGF) and Its Soluble Receptor-1 in Endometriosis." Microvascular Research, vol. 83, no. 2, 2012, pp. 237-42.
Cho S, Choi YS, Jeon YE, et al. Expression of vascular endothelial growth factor (VEGF) and its soluble receptor-1 in endometriosis. Microvasc Res. 2012;83(2):237-42.
Cho, S., Choi, Y. S., Jeon, Y. E., Im, K. J., Choi, Y. M., Yim, S. Y., Kim, H., Seo, S. K., & Lee, B. S. (2012). Expression of vascular endothelial growth factor (VEGF) and its soluble receptor-1 in endometriosis. Microvascular Research, 83(2), 237-42. https://doi.org/10.1016/j.mvr.2011.12.004
Cho S, et al. Expression of Vascular Endothelial Growth Factor (VEGF) and Its Soluble Receptor-1 in Endometriosis. Microvasc Res. 2012;83(2):237-42. PubMed PMID: 22230112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of vascular endothelial growth factor (VEGF) and its soluble receptor-1 in endometriosis. AU - Cho,SiHyun, AU - Choi,Young Sik, AU - Jeon,Young Eun, AU - Im,Kyung Jin, AU - Choi,Young Mi, AU - Yim,Su Youn, AU - Kim,HyeYeon, AU - Seo,Seok Kyo, AU - Lee,Byung Seok, Y1 - 2012/01/02/ PY - 2011/07/27/received PY - 2011/11/21/revised PY - 2011/12/21/accepted PY - 2012/1/11/entrez PY - 2012/1/11/pubmed PY - 2012/6/7/medline SP - 237 EP - 42 JF - Microvascular research JO - Microvasc. Res. VL - 83 IS - 2 N2 - The aim of this study is to evaluate the expression of vascular endothelial growth factor (VEGF) and its soluble receptor (sFlt-1) in peritoneal fluid (PF), peritoneal endometriotic lesions and eutopic endometrial tissues of patients with endometriosis. Peritoneal fluid, peritoneal endometriotic lesions and eutopic endometrial samples from patients with endometriosis, and peritoneal fluid, peritoneal tissue and endometrial samples from patients without endometriosis were obtained during an operative laparoscopy. The mean PF concentrations of VEGF and sFlt-1 were significantly higher in patients with endometriosis than in the controls. In the peritoneal tissue, the expressions of VEGF and sFlt-1 were significantly higher, where the expression of sFlt-1 in endometrium was significantly lower in patients with endometriosis. These findings indicate that not only abnormal expressions of angiogenic factors, but also aberrant expressions of antiangiogenic factors in the peritoneal and endometrial environment seem to be involved in the pathogenesis of endometriosis. SN - 1095-9319 UR - https://www.unboundmedicine.com/medline/citation/22230112/Expression_of_vascular_endothelial_growth_factor__VEGF__and_its_soluble_receptor_1_in_endometriosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-2862(11)00231-7 DB - PRIME DP - Unbound Medicine ER -