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Antibody against Haemophilus influenzae protein D in patients with chronic conditions causing secondary immunodeficiency.
Vaccine. 2012 Feb 08; 30(7):1235-8.V

Abstract

Prevalence of non-typeable Haemophilus influenzae (NTHi) in the etiology of invasive infections in immunocompromised individuals is increasing. Serum IgG antibody levels to H. influenzae protein D (PD) were significantly lower in adults suffering from chronic conditions causing secondary immunodeficiency (COPD, cancer, chronic renal failure, and diabetes) compared to age-matched healthy controls. A lack of naturally acquired antibody against this highly conserved antigen may contribute to an increased susceptibility to invasive NTHi disease. As COPD patients frequently infected with NTHi during disease exacerbations were unable to develop antibody response to PD, such defect could potentially contribute to the pathogenesis. Considering that pediatric PD-containing vaccines show protective effect against NTHi-caused otitis media, our data suggest the possibility of improving the defense against NTHi in COPD patients using immunization against PD. Although more research on the role of anti-PD antibody in protection against invasive NTHi disease is warranted, development of adult formulations of PD-based vaccines may be advantageous for prevention of severe infections in immunocompromised individuals.

Authors+Show Affiliations

Northern Ontario School of Medicine, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario, 57B5E1, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22230580

Citation

Hawdon, N, et al. "Antibody Against Haemophilus Influenzae Protein D in Patients With Chronic Conditions Causing Secondary Immunodeficiency." Vaccine, vol. 30, no. 7, 2012, pp. 1235-8.
Hawdon N, Biman B, McCready W, et al. Antibody against Haemophilus influenzae protein D in patients with chronic conditions causing secondary immunodeficiency. Vaccine. 2012;30(7):1235-8.
Hawdon, N., Biman, B., McCready, W., Brigden, M., Malik, S., Vergidis, D., Kisselgoff, O., & Ulanova, M. (2012). Antibody against Haemophilus influenzae protein D in patients with chronic conditions causing secondary immunodeficiency. Vaccine, 30(7), 1235-8. https://doi.org/10.1016/j.vaccine.2011.12.113
Hawdon N, et al. Antibody Against Haemophilus Influenzae Protein D in Patients With Chronic Conditions Causing Secondary Immunodeficiency. Vaccine. 2012 Feb 8;30(7):1235-8. PubMed PMID: 22230580.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibody against Haemophilus influenzae protein D in patients with chronic conditions causing secondary immunodeficiency. AU - Hawdon,N, AU - Biman,B, AU - McCready,W, AU - Brigden,M, AU - Malik,S, AU - Vergidis,D, AU - Kisselgoff,O, AU - Ulanova,M, Y1 - 2012/01/09/ PY - 2011/06/21/received PY - 2011/12/23/revised PY - 2011/12/27/accepted PY - 2012/1/11/entrez PY - 2012/1/11/pubmed PY - 2013/3/2/medline SP - 1235 EP - 8 JF - Vaccine JO - Vaccine VL - 30 IS - 7 N2 - Prevalence of non-typeable Haemophilus influenzae (NTHi) in the etiology of invasive infections in immunocompromised individuals is increasing. Serum IgG antibody levels to H. influenzae protein D (PD) were significantly lower in adults suffering from chronic conditions causing secondary immunodeficiency (COPD, cancer, chronic renal failure, and diabetes) compared to age-matched healthy controls. A lack of naturally acquired antibody against this highly conserved antigen may contribute to an increased susceptibility to invasive NTHi disease. As COPD patients frequently infected with NTHi during disease exacerbations were unable to develop antibody response to PD, such defect could potentially contribute to the pathogenesis. Considering that pediatric PD-containing vaccines show protective effect against NTHi-caused otitis media, our data suggest the possibility of improving the defense against NTHi in COPD patients using immunization against PD. Although more research on the role of anti-PD antibody in protection against invasive NTHi disease is warranted, development of adult formulations of PD-based vaccines may be advantageous for prevention of severe infections in immunocompromised individuals. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/22230580/Antibody_against_Haemophilus_influenzae_protein_D_in_patients_with_chronic_conditions_causing_secondary_immunodeficiency_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(11)02074-3 DB - PRIME DP - Unbound Medicine ER -