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Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer.
J Mol Med (Berl). 2012 Aug; 90(8):925-34.JM

Abstract

Colon cancer affects millions of individuals in Western countries. Cannabidiol, a safe and non-psychotropic ingredient of Cannabis sativa, exerts pharmacological actions (antioxidant and intestinal antinflammatory) and mechanisms (inhibition of endocannabinoid enzymatic degradation) potentially beneficial for colon carcinogenesis. Thus, we investigated its possible chemopreventive effect in the model of colon cancer induced by azoxymethane (AOM) in mice. AOM treatment was associated with aberrant crypt foci (ACF, preneoplastic lesions), polyps, and tumour formation, up-regulation of phospho-Akt, iNOS and COX-2 and down-regulation of caspase-3. Cannabidiol-reduced ACF, polyps and tumours and counteracted AOM-induced phospho-Akt and caspase-3 changes. In colorectal carcinoma cell lines, cannabidiol protected DNA from oxidative damage, increased endocannabinoid levels and reduced cell proliferation in a CB(1)-, TRPV1- and PPARγ-antagonists sensitive manner. It is concluded that cannabidiol exerts chemopreventive effect in vivo and reduces cell proliferation through multiple mechanisms.

Authors+Show Affiliations

Department of Experimental Pharmacology, Endocannabinoid Research Group, University of Naples Federico II, Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22231745

Citation

Aviello, Gabriella, et al. "Chemopreventive Effect of the Non-psychotropic Phytocannabinoid Cannabidiol On Experimental Colon Cancer." Journal of Molecular Medicine (Berlin, Germany), vol. 90, no. 8, 2012, pp. 925-34.
Aviello G, Romano B, Borrelli F, et al. Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer. J Mol Med (Berl). 2012;90(8):925-34.
Aviello, G., Romano, B., Borrelli, F., Capasso, R., Gallo, L., Piscitelli, F., Di Marzo, V., & Izzo, A. A. (2012). Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer. Journal of Molecular Medicine (Berlin, Germany), 90(8), 925-34. https://doi.org/10.1007/s00109-011-0856-x
Aviello G, et al. Chemopreventive Effect of the Non-psychotropic Phytocannabinoid Cannabidiol On Experimental Colon Cancer. J Mol Med (Berl). 2012;90(8):925-34. PubMed PMID: 22231745.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer. AU - Aviello,Gabriella, AU - Romano,Barbara, AU - Borrelli,Francesca, AU - Capasso,Raffaele, AU - Gallo,Laura, AU - Piscitelli,Fabiana, AU - Di Marzo,Vincenzo, AU - Izzo,Angelo A, Y1 - 2012/01/10/ PY - 2011/10/11/received PY - 2011/12/14/accepted PY - 2011/11/23/revised PY - 2012/1/11/entrez PY - 2012/1/11/pubmed PY - 2012/12/10/medline SP - 925 EP - 34 JF - Journal of molecular medicine (Berlin, Germany) JO - J Mol Med (Berl) VL - 90 IS - 8 N2 - Colon cancer affects millions of individuals in Western countries. Cannabidiol, a safe and non-psychotropic ingredient of Cannabis sativa, exerts pharmacological actions (antioxidant and intestinal antinflammatory) and mechanisms (inhibition of endocannabinoid enzymatic degradation) potentially beneficial for colon carcinogenesis. Thus, we investigated its possible chemopreventive effect in the model of colon cancer induced by azoxymethane (AOM) in mice. AOM treatment was associated with aberrant crypt foci (ACF, preneoplastic lesions), polyps, and tumour formation, up-regulation of phospho-Akt, iNOS and COX-2 and down-regulation of caspase-3. Cannabidiol-reduced ACF, polyps and tumours and counteracted AOM-induced phospho-Akt and caspase-3 changes. In colorectal carcinoma cell lines, cannabidiol protected DNA from oxidative damage, increased endocannabinoid levels and reduced cell proliferation in a CB(1)-, TRPV1- and PPARγ-antagonists sensitive manner. It is concluded that cannabidiol exerts chemopreventive effect in vivo and reduces cell proliferation through multiple mechanisms. SN - 1432-1440 UR - https://www.unboundmedicine.com/medline/citation/22231745/Chemopreventive_effect_of_the_non_psychotropic_phytocannabinoid_cannabidiol_on_experimental_colon_cancer_ L2 - https://antibodies.cancer.gov/detail/CPTC-AKT1-3 DB - PRIME DP - Unbound Medicine ER -