TY - JOUR T1 - Inhibitory effects of water-soluble low-molecular-weight β-(1,3-1,6) D-glucan isolated from Aureobasidium pullulans 1A1 strain black yeast on mast cell degranulation and passive cutaneous anaphylaxis. AU - Sato,Harumi, AU - Kobayashi,Yuko, AU - Hattori,Atsushi, AU - Suzuki,Toshio, AU - Shigekawa,Munekazu, AU - Jippo,Tomoko, Y1 - 2012/01/07/ PY - 2012/1/11/entrez PY - 2012/1/11/pubmed PY - 2012/5/19/medline SP - 84 EP - 8 JF - Bioscience, biotechnology, and biochemistry JO - Biosci Biotechnol Biochem VL - 76 IS - 1 N2 - We investigated the effects of water-soluble low-molecular-weight β-(1,3-1,6) D-glucan isolated from Aureobasidium pullulans 1A1 strain black yeast (LMW-β-glucan) on mast cell-mediated anaphylactic reactions. Although it is known that LMW-β-glucan has anti-tumor, anti-metastatic and anti-stress effects, the roles of LMW-β-glucan in immediate-type allergic reactions have not been fully investigated. We examined whether LMW-β-glucan could inhibit mast cell degranulation and passive cutaneous anaphylaxis (PCA). LMW-β-glucan dose-dependently inhibited the degranulation of both rat basophilic leukemia (RBL-2H3) and cultured mast cells (CMCs) activated by calcium ionophore A23187 or IgE. However, LMW-β-glucan had no cytotoxicity towards RBL-2H3 cells and CMCs. Furthermore, orally administered LMW-β-glucan inhibited the IgE-induced PCA reaction in mice. These results show LMW-β-glucan to be a possible compound for the effective therapeutic treatment of allergic diseases. SN - 1347-6947 UR - https://www.unboundmedicine.com/medline/citation/22232243/Inhibitory_effects_of_water_soluble_low_molecular_weight_β__13_16__D_glucan_isolated_from_Aureobasidium_pullulans_1A1_strain_black_yeast_on_mast_cell_degranulation_and_passive_cutaneous_anaphylaxis_ L2 - https://joi.jlc.jst.go.jp/JST.JSTAGE/bbb/110536?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -