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Evaluation of the 2009 WHO dengue case classification in an Indonesian pediatric cohort.
Am J Trop Med Hyg. 2012 Jan; 86(1):166-70.AJ

Abstract

The classification of dengue virus-infected patients continues to be a challenge to researchers and clinicians in the field. The accuracy of the 1997 World Health Organization (WHO) dengue case definition has been debated for a decade, because the definition was very stringent, for instance, several researchers showed that apparently severe cases were misclassified as not severe. Therefore the WHO issued revised guidelines in 2009. Here, we retrospectively compared the performance of the WHO case definition of 2009 with the WHO case definition of 1997 in a detailed documented pediatric cohort from Indonesia. Intensive treatment intervention was used as an indicator of severity of disease. In line with our expectations, the 2009 WHO case classification proved to be significantly more specific, albeit less sensitive than the WHO case classification of 1997. We conclude that the revised classification is promising both from research and clinical perspectives, but validation of the classification criteria still needs to be addressed.

Authors+Show Affiliations

Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands. c.vandeweg@erasmusmc.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22232468

Citation

van de Weg, Cornelia A M., et al. "Evaluation of the 2009 WHO Dengue Case Classification in an Indonesian Pediatric Cohort." The American Journal of Tropical Medicine and Hygiene, vol. 86, no. 1, 2012, pp. 166-70.
van de Weg CA, van Gorp EC, Supriatna M, et al. Evaluation of the 2009 WHO dengue case classification in an Indonesian pediatric cohort. Am J Trop Med Hyg. 2012;86(1):166-70.
van de Weg, C. A., van Gorp, E. C., Supriatna, M., Soemantri, A., Osterhaus, A. D., & Martina, B. E. (2012). Evaluation of the 2009 WHO dengue case classification in an Indonesian pediatric cohort. The American Journal of Tropical Medicine and Hygiene, 86(1), 166-70. https://doi.org/10.4269/ajtmh.2012.11-0491
van de Weg CA, et al. Evaluation of the 2009 WHO Dengue Case Classification in an Indonesian Pediatric Cohort. Am J Trop Med Hyg. 2012;86(1):166-70. PubMed PMID: 22232468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the 2009 WHO dengue case classification in an Indonesian pediatric cohort. AU - van de Weg,Cornelia A M, AU - van Gorp,Eric C M, AU - Supriatna,Mohamad, AU - Soemantri,Augustinus, AU - Osterhaus,Albert D M E, AU - Martina,Byron E E, PY - 2012/1/11/entrez PY - 2012/1/11/pubmed PY - 2012/3/10/medline SP - 166 EP - 70 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 86 IS - 1 N2 - The classification of dengue virus-infected patients continues to be a challenge to researchers and clinicians in the field. The accuracy of the 1997 World Health Organization (WHO) dengue case definition has been debated for a decade, because the definition was very stringent, for instance, several researchers showed that apparently severe cases were misclassified as not severe. Therefore the WHO issued revised guidelines in 2009. Here, we retrospectively compared the performance of the WHO case definition of 2009 with the WHO case definition of 1997 in a detailed documented pediatric cohort from Indonesia. Intensive treatment intervention was used as an indicator of severity of disease. In line with our expectations, the 2009 WHO case classification proved to be significantly more specific, albeit less sensitive than the WHO case classification of 1997. We conclude that the revised classification is promising both from research and clinical perspectives, but validation of the classification criteria still needs to be addressed. SN - 1476-1645 UR - https://www.unboundmedicine.com/medline/citation/22232468/Evaluation_of_the_2009_WHO_dengue_case_classification_in_an_Indonesian_pediatric_cohort_ L2 - https://ajtmh.org/doi/10.4269/ajtmh.2012.11-0491 DB - PRIME DP - Unbound Medicine ER -