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Health-related quality of life and depressive symptoms in significant others of people with multiple sclerosis: a community study.
Eur J Neurol 2012; 19(6):847-54EJ

Abstract

BACKGROUND AND PURPOSE

Uncertain prognosis and modest treatment efficacy make multiple sclerosis (MS) a particularly difficult disease to adjust to for both patients and their significant others (SOs). Few studies have assessed health-related quality of life (HRQOL) and depressive symptoms in SOs of people with MS in the community. We assessed, and identified predictors of, HRQOL and depression in SOs of adults with MS.

METHODS

POSMOS (postal survey of self-assessed health in MS adults and SOs) is a longitudinal survey on a random sample of 251 people with MS in the Milan area. In 2010, SOs and contemporaneous controls completed the SF-36 and Chicago Multiscale Depression Inventory (CMDI).

RESULTS

Overall, 142 SOs (mean age 53.1 years; 50% women, 65% partners) and 120 controls (similar to SOs for sex and education, but older) participated. By multivariable modeling of the SO plus control population, SF-36 vitality was lower in SOs (proportional odds ratio 0.45; 95% confidence interval 0.28-0.70), women (0.41; 0.27-0.64), and older subjects (0.98; 0.97-0.99). SF-36 mental health was also lower in SOs (0.62; 0.40-0.96) and women (0.43; 0.28-0.67). Regarding MS characteristics associated with HRQOL and depression in SOs, severe disability [Expanded Disability Status Scale (EDSS > 6.5)] had no effect, whilst depressive symptoms (pathologic CMDI) negatively influenced most SF-36 and all CMDI scores in SOs.

CONCLUSIONS

SOs had significantly lower vitality and psychological well-being than controls, identifying a burden in being the companion of a person with MS. This burden was unrelated to physical compromise but associated with depressive symptoms in MS.

Authors+Show Affiliations

Unit of Neuroepidemiology, Foundation IRCCS Neurological Institute C. Besta, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22233289

Citation

Giordano, A, et al. "Health-related Quality of Life and Depressive Symptoms in Significant Others of People With Multiple Sclerosis: a Community Study." European Journal of Neurology, vol. 19, no. 6, 2012, pp. 847-54.
Giordano A, Ferrari G, Radice D, et al. Health-related quality of life and depressive symptoms in significant others of people with multiple sclerosis: a community study. Eur J Neurol. 2012;19(6):847-54.
Giordano, A., Ferrari, G., Radice, D., Randi, G., Bisanti, L., & Solari, A. (2012). Health-related quality of life and depressive symptoms in significant others of people with multiple sclerosis: a community study. European Journal of Neurology, 19(6), pp. 847-54. doi:10.1111/j.1468-1331.2011.03638.x.
Giordano A, et al. Health-related Quality of Life and Depressive Symptoms in Significant Others of People With Multiple Sclerosis: a Community Study. Eur J Neurol. 2012;19(6):847-54. PubMed PMID: 22233289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Health-related quality of life and depressive symptoms in significant others of people with multiple sclerosis: a community study. AU - Giordano,A, AU - Ferrari,G, AU - Radice,D, AU - Randi,G, AU - Bisanti,L, AU - Solari,A, AU - ,, Y1 - 2012/01/10/ PY - 2012/1/12/entrez PY - 2012/1/12/pubmed PY - 2012/9/15/medline SP - 847 EP - 54 JF - European journal of neurology JO - Eur. J. Neurol. VL - 19 IS - 6 N2 - BACKGROUND AND PURPOSE: Uncertain prognosis and modest treatment efficacy make multiple sclerosis (MS) a particularly difficult disease to adjust to for both patients and their significant others (SOs). Few studies have assessed health-related quality of life (HRQOL) and depressive symptoms in SOs of people with MS in the community. We assessed, and identified predictors of, HRQOL and depression in SOs of adults with MS. METHODS: POSMOS (postal survey of self-assessed health in MS adults and SOs) is a longitudinal survey on a random sample of 251 people with MS in the Milan area. In 2010, SOs and contemporaneous controls completed the SF-36 and Chicago Multiscale Depression Inventory (CMDI). RESULTS: Overall, 142 SOs (mean age 53.1 years; 50% women, 65% partners) and 120 controls (similar to SOs for sex and education, but older) participated. By multivariable modeling of the SO plus control population, SF-36 vitality was lower in SOs (proportional odds ratio 0.45; 95% confidence interval 0.28-0.70), women (0.41; 0.27-0.64), and older subjects (0.98; 0.97-0.99). SF-36 mental health was also lower in SOs (0.62; 0.40-0.96) and women (0.43; 0.28-0.67). Regarding MS characteristics associated with HRQOL and depression in SOs, severe disability [Expanded Disability Status Scale (EDSS > 6.5)] had no effect, whilst depressive symptoms (pathologic CMDI) negatively influenced most SF-36 and all CMDI scores in SOs. CONCLUSIONS: SOs had significantly lower vitality and psychological well-being than controls, identifying a burden in being the companion of a person with MS. This burden was unrelated to physical compromise but associated with depressive symptoms in MS. SN - 1468-1331 UR - https://www.unboundmedicine.com/medline/citation/22233289/Health_related_quality_of_life_and_depressive_symptoms_in_significant_others_of_people_with_multiple_sclerosis:_a_community_study_ L2 - https://doi.org/10.1111/j.1468-1331.2011.03638.x DB - PRIME DP - Unbound Medicine ER -