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Injury markers but not amyloid markers are associated with rapid progression from mild cognitive impairment to dementia in Alzheimer's disease.
J Alzheimers Dis 2012; 29(2):319-27JA

Abstract

Alzheimer's disease (AD) is a common cause of mild cognitive impairment (MCI). However, the time between the diagnosis of MCI and the diagnosis of dementia is highly variable. In this study we investigated which known risk factors and biomarkers of AD pathology were associated with rapid progression from MCI to dementia. Of the 203 subjects with MCI, 91 progressed to AD-type dementia and were considered to have MCI-AD at baseline. Subjects with MCI-AD were older, more frequently female and carrier of the APOE-ε4 allele, had lower scores on the Mini-Mental State Examination (MMSE), more medial temporal lobe atrophy (MTA) and lower levels of Aβ1-42 and increased levels of t-tau and p-tau in the cerebrospinal fluid (CSF) compared to subjects without AD-type dementia at follow up. Of the 91 subjects with MCI-AD, we had data available of CSF (n = 56), MTA (n = 76), and APOE-genotype (n = 63). Among the subjects with MCI-AD, MTA (hazard ratio (HR) 2.2, p = 0.004) and low MMSE score (HR 2.0 p = 0.007) were associated with rapid progression to dementia. High CSF t-tau (HR 1.7, p = 0.07) and p-tau (1.7, p = 0.08) tended to be associated with rapid progression to dementia. CSF Aβ1-42, APOE status, age, gender, and educational level were not associated with time to dementia. Our findings implicate a different role for biomarkers in diagnosis and prognosis of MCI-AD. While amyloid markers can be used to identify MCI-AD, injury markers may predict rapid progression to dementia.

Authors+Show Affiliations

Department of Neurology/Alzheimer Center, VU Medical Center, Amsterdam, The Netherlands. i.vanrossum@vumc.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22233766

Citation

van Rossum, Ineke A., et al. "Injury Markers but Not Amyloid Markers Are Associated With Rapid Progression From Mild Cognitive Impairment to Dementia in Alzheimer's Disease." Journal of Alzheimer's Disease : JAD, vol. 29, no. 2, 2012, pp. 319-27.
van Rossum IA, Visser PJ, Knol DL, et al. Injury markers but not amyloid markers are associated with rapid progression from mild cognitive impairment to dementia in Alzheimer's disease. J Alzheimers Dis. 2012;29(2):319-27.
van Rossum, I. A., Visser, P. J., Knol, D. L., van der Flier, W. M., Teunissen, C. E., Barkhof, F., ... Scheltens, P. (2012). Injury markers but not amyloid markers are associated with rapid progression from mild cognitive impairment to dementia in Alzheimer's disease. Journal of Alzheimer's Disease : JAD, 29(2), pp. 319-27. doi:10.3233/JAD-2011-111694.
van Rossum IA, et al. Injury Markers but Not Amyloid Markers Are Associated With Rapid Progression From Mild Cognitive Impairment to Dementia in Alzheimer's Disease. J Alzheimers Dis. 2012;29(2):319-27. PubMed PMID: 22233766.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Injury markers but not amyloid markers are associated with rapid progression from mild cognitive impairment to dementia in Alzheimer's disease. AU - van Rossum,Ineke A, AU - Visser,Pieter Jelle, AU - Knol,Dirk L, AU - van der Flier,Wiesje M, AU - Teunissen,Charlotte E, AU - Barkhof,Frederik, AU - Blankenstein,Marinus A, AU - Scheltens,Philip, PY - 2012/1/12/entrez PY - 2012/1/12/pubmed PY - 2012/7/27/medline SP - 319 EP - 27 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 29 IS - 2 N2 - Alzheimer's disease (AD) is a common cause of mild cognitive impairment (MCI). However, the time between the diagnosis of MCI and the diagnosis of dementia is highly variable. In this study we investigated which known risk factors and biomarkers of AD pathology were associated with rapid progression from MCI to dementia. Of the 203 subjects with MCI, 91 progressed to AD-type dementia and were considered to have MCI-AD at baseline. Subjects with MCI-AD were older, more frequently female and carrier of the APOE-ε4 allele, had lower scores on the Mini-Mental State Examination (MMSE), more medial temporal lobe atrophy (MTA) and lower levels of Aβ1-42 and increased levels of t-tau and p-tau in the cerebrospinal fluid (CSF) compared to subjects without AD-type dementia at follow up. Of the 91 subjects with MCI-AD, we had data available of CSF (n = 56), MTA (n = 76), and APOE-genotype (n = 63). Among the subjects with MCI-AD, MTA (hazard ratio (HR) 2.2, p = 0.004) and low MMSE score (HR 2.0 p = 0.007) were associated with rapid progression to dementia. High CSF t-tau (HR 1.7, p = 0.07) and p-tau (1.7, p = 0.08) tended to be associated with rapid progression to dementia. CSF Aβ1-42, APOE status, age, gender, and educational level were not associated with time to dementia. Our findings implicate a different role for biomarkers in diagnosis and prognosis of MCI-AD. While amyloid markers can be used to identify MCI-AD, injury markers may predict rapid progression to dementia. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/22233766/Injury_markers_but_not_amyloid_markers_are_associated_with_rapid_progression_from_mild_cognitive_impairment_to_dementia_in_Alzheimer's_disease_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-2011-111694 DB - PRIME DP - Unbound Medicine ER -