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Neuronal populations mediating the effects of endocannabinoids on stress and emotionality.

Abstract

An adequate emotional response to stress is essential for survival and requires the fine-tuned regulation of several distinct neuronal circuits. Therefore, a precise control of these circuits is necessary to prevent behavioral imbalances. During the last decade, numerous investigations have evidenced that the endocannabinoid (eCB) system is able to crucially control stress coping. Its central component, the cannabinoid type 1 receptor (CB1 receptor), is located at the presynapse, where it is able to attenuate neurotransmitter release after its activation by postsynaptically produced and released eCBs. To date, the eCB system has been found to control the neurotransmitter release from several neuron populations (e.g. GABA, glutamate, catecholamines and monoamines), suggesting a general mechanism for tuning neuronal activity, and thereby regulating emotion and stress responses. In this review, we aim at summarizing the anatomical and functional relation of the eCB system to an adequate response to stressful situations. Of special interest will be neuronal connections to the hypothalamic-pituitary-adrenal axis, but also circuits between cortical structures, such as prefrontal cortex, amygdala and hippocampus, and subcortical regions, such as raphe nuclei and locus coeruleus. We further like to step toward allocating eCB system functions to distinct cellular subpopulations in the brain. It has emerged that the eCB system is spatially well defined, and its detailed knowledge is a prerequisite for understanding the eCB system in the context of controlling behavior. Thus, advanced approaches combining different genetic and pharmacological tools to dissect specific eCB system functions are of particular interest.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, 55128 Mainz, Germany.

    ,

    Source

    Neuroscience 204: 2012 Mar 01 pg 145-58

    MeSH

    Animals
    Cannabinoid Receptor Modulators
    Emotions
    Endocannabinoids
    Hypothalamo-Hypophyseal System
    Neurons
    Pituitary-Adrenal System
    Receptor, Cannabinoid, CB1
    Stress, Physiological
    Stress, Psychological
    Synapses

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    22233782

    Citation

    Häring, M, et al. "Neuronal Populations Mediating the Effects of Endocannabinoids On Stress and Emotionality." Neuroscience, vol. 204, 2012, pp. 145-58.
    Häring M, Guggenhuber S, Lutz B. Neuronal populations mediating the effects of endocannabinoids on stress and emotionality. Neuroscience. 2012;204:145-58.
    Häring, M., Guggenhuber, S., & Lutz, B. (2012). Neuronal populations mediating the effects of endocannabinoids on stress and emotionality. Neuroscience, 204, pp. 145-58. doi:10.1016/j.neuroscience.2011.12.035.
    Häring M, Guggenhuber S, Lutz B. Neuronal Populations Mediating the Effects of Endocannabinoids On Stress and Emotionality. Neuroscience. 2012 Mar 1;204:145-58. PubMed PMID: 22233782.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Neuronal populations mediating the effects of endocannabinoids on stress and emotionality. AU - Häring,M, AU - Guggenhuber,S, AU - Lutz,B, Y1 - 2012/01/02/ PY - 2011/10/03/received PY - 2011/12/12/revised PY - 2011/12/12/accepted PY - 2012/1/12/entrez PY - 2012/1/12/pubmed PY - 2012/7/24/medline SP - 145 EP - 58 JF - Neuroscience JO - Neuroscience VL - 204 N2 - An adequate emotional response to stress is essential for survival and requires the fine-tuned regulation of several distinct neuronal circuits. Therefore, a precise control of these circuits is necessary to prevent behavioral imbalances. During the last decade, numerous investigations have evidenced that the endocannabinoid (eCB) system is able to crucially control stress coping. Its central component, the cannabinoid type 1 receptor (CB1 receptor), is located at the presynapse, where it is able to attenuate neurotransmitter release after its activation by postsynaptically produced and released eCBs. To date, the eCB system has been found to control the neurotransmitter release from several neuron populations (e.g. GABA, glutamate, catecholamines and monoamines), suggesting a general mechanism for tuning neuronal activity, and thereby regulating emotion and stress responses. In this review, we aim at summarizing the anatomical and functional relation of the eCB system to an adequate response to stressful situations. Of special interest will be neuronal connections to the hypothalamic-pituitary-adrenal axis, but also circuits between cortical structures, such as prefrontal cortex, amygdala and hippocampus, and subcortical regions, such as raphe nuclei and locus coeruleus. We further like to step toward allocating eCB system functions to distinct cellular subpopulations in the brain. It has emerged that the eCB system is spatially well defined, and its detailed knowledge is a prerequisite for understanding the eCB system in the context of controlling behavior. Thus, advanced approaches combining different genetic and pharmacological tools to dissect specific eCB system functions are of particular interest. SN - 1873-7544 UR - https://www.unboundmedicine.com/medline/citation/22233782/Neuronal_populations_mediating_the_effects_of_endocannabinoids_on_stress_and_emotionality_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(11)01432-1 DB - PRIME DP - Unbound Medicine ER -