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Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT.
Eur J Clin Nutr. 2012 Mar; 66(3):399-404.EJ

Abstract

BACKGROUND/OBJECTIVES

Our objective was to investigate effects of an oral nutritional supplement containing n-3 polyunsaturated fatty acids (FAs) on quality of life, performance status, handgrip strength and physical activity in patients with non-small cell lung cancer (NSCLC) undergoing multimodality treatment.

SUBJECTS/METHODS

In a double-blind experiment, 40 patients with stage III NSCLC were randomised to receive 2 cans/day of a protein- and energy-dense oral nutritional supplement containing n-3 polyunsaturated FAs (2.02 g eicosapentaenoic acid+0.92 g docosahexaenoic acid/day) or an isocaloric control supplement, during multimodality treatment. Quality of life, Karnofsky Performance Status, handgrip strength and physical activity (by wearing an accelerometer) were assessed. Effects of intervention were analysed by generalised estimating equations. P-values <0.05 were regarded as statistically significant.

RESULTS

The intervention group reported significantly higher on the quality of life parameters, physical and cognitive function (B=11.6 and B=20.7, P<0.01), global health status (B=12.2, P=0.04) and social function (B=22.1, P=0.04) than the control group after 5 weeks. The intervention group showed a higher Karnofsky Performance Status (B=5.3, P=0.04) than the control group after 3 weeks. Handgrip strength did not significantly differ between groups over time. The intervention group tended to have a higher physical activity than the control group after 3 and 5 weeks (B=6.6, P=0.04 and B=2.5, P=0.05).

CONCLUSION

n-3 Polyunsaturated FAs may beneficially affect quality of life, performance status and physical activity in patients with NSCLC undergoing multimodality treatment.

Authors+Show Affiliations

Department of Nutrition and Dietetics, Internal Medicine, VU University Medical Center Amsterdam, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22234041

Citation

van der Meij, B S., et al. "Oral Nutritional Supplements Containing N-3 Polyunsaturated Fatty Acids Affect Quality of Life and Functional Status in Lung Cancer Patients During Multimodality Treatment: an RCT." European Journal of Clinical Nutrition, vol. 66, no. 3, 2012, pp. 399-404.
van der Meij BS, Langius JA, Spreeuwenberg MD, et al. Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT. Eur J Clin Nutr. 2012;66(3):399-404.
van der Meij, B. S., Langius, J. A., Spreeuwenberg, M. D., Slootmaker, S. M., Paul, M. A., Smit, E. F., & van Leeuwen, P. A. (2012). Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT. European Journal of Clinical Nutrition, 66(3), 399-404. https://doi.org/10.1038/ejcn.2011.214
van der Meij BS, et al. Oral Nutritional Supplements Containing N-3 Polyunsaturated Fatty Acids Affect Quality of Life and Functional Status in Lung Cancer Patients During Multimodality Treatment: an RCT. Eur J Clin Nutr. 2012;66(3):399-404. PubMed PMID: 22234041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT. AU - van der Meij,B S, AU - Langius,J A E, AU - Spreeuwenberg,M D, AU - Slootmaker,S M, AU - Paul,M A, AU - Smit,E F, AU - van Leeuwen,P A M, Y1 - 2012/01/11/ PY - 2012/1/12/entrez PY - 2012/1/12/pubmed PY - 2012/7/28/medline SP - 399 EP - 404 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 66 IS - 3 N2 - BACKGROUND/OBJECTIVES: Our objective was to investigate effects of an oral nutritional supplement containing n-3 polyunsaturated fatty acids (FAs) on quality of life, performance status, handgrip strength and physical activity in patients with non-small cell lung cancer (NSCLC) undergoing multimodality treatment. SUBJECTS/METHODS: In a double-blind experiment, 40 patients with stage III NSCLC were randomised to receive 2 cans/day of a protein- and energy-dense oral nutritional supplement containing n-3 polyunsaturated FAs (2.02 g eicosapentaenoic acid+0.92 g docosahexaenoic acid/day) or an isocaloric control supplement, during multimodality treatment. Quality of life, Karnofsky Performance Status, handgrip strength and physical activity (by wearing an accelerometer) were assessed. Effects of intervention were analysed by generalised estimating equations. P-values <0.05 were regarded as statistically significant. RESULTS: The intervention group reported significantly higher on the quality of life parameters, physical and cognitive function (B=11.6 and B=20.7, P<0.01), global health status (B=12.2, P=0.04) and social function (B=22.1, P=0.04) than the control group after 5 weeks. The intervention group showed a higher Karnofsky Performance Status (B=5.3, P=0.04) than the control group after 3 weeks. Handgrip strength did not significantly differ between groups over time. The intervention group tended to have a higher physical activity than the control group after 3 and 5 weeks (B=6.6, P=0.04 and B=2.5, P=0.05). CONCLUSION: n-3 Polyunsaturated FAs may beneficially affect quality of life, performance status and physical activity in patients with NSCLC undergoing multimodality treatment. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/22234041/Oral_nutritional_supplements_containing_n_3_polyunsaturated_fatty_acids_affect_quality_of_life_and_functional_status_in_lung_cancer_patients_during_multimodality_treatment:_an_RCT_ L2 - https://doi.org/10.1038/ejcn.2011.214 DB - PRIME DP - Unbound Medicine ER -