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Malignant transformation in a hybrid schwannoma/perineurioma: addition to the spectrum of a malignant peripheral nerve sheath tumor.
Indian J Pathol Microbiol. 2011 Oct-Dec; 54(4):825-8.IJ

Abstract

Benign nerve sheath tumors include schwannomas, neurofibromas and perineuriomas. The malignant counterpart of a nerve sheath tumor is designated as a malignant peripheral nerve sheath tumor (MPNST). Lately, benign nerve sheath tumors comprising more than one component have been described, including hybrid schwannomas/perineuriomas. However, malignant transformation in a hybrid schwannoma/perineurioma has not been documented so far. Herein, we present a rare case of a young adult male who presented with a soft tissue mass in his right thigh that was excised elsewhere and submitted to us for histopathological review. One of the tissue sections displayed histopathological features of a hybrid schwannoma/perineurioma, including alternate arrangement of benign schwann and perineurial cells, reinforced with S100-P and epithelial membrane antigen positivity, respectively, along with low MIB1 and negative p53 immunostaining. The other two tissue sections showed a spindly sarcomatous tumor that was immunohistochemically positive for S100-P, CD34, p53 and exhibited high MIB1 (30-40%). Diagnosis of a MPNST arising in a hybrid schwannoma/perineurioma was made. This unusual case forms yet another addition to the spectrum of a MPNST.

Authors+Show Affiliations

Department of Pathology, Tata Memorial Hospital, Mumbai, India. rekhi.bharat@gmail.comNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

22234123

Citation

Rekhi, Bharat, and Nirmala A. Jambhekar. "Malignant Transformation in a Hybrid Schwannoma/perineurioma: Addition to the Spectrum of a Malignant Peripheral Nerve Sheath Tumor." Indian Journal of Pathology & Microbiology, vol. 54, no. 4, 2011, pp. 825-8.
Rekhi B, Jambhekar NA. Malignant transformation in a hybrid schwannoma/perineurioma: addition to the spectrum of a malignant peripheral nerve sheath tumor. Indian J Pathol Microbiol. 2011;54(4):825-8.
Rekhi, B., & Jambhekar, N. A. (2011). Malignant transformation in a hybrid schwannoma/perineurioma: addition to the spectrum of a malignant peripheral nerve sheath tumor. Indian Journal of Pathology & Microbiology, 54(4), 825-8. https://doi.org/10.4103/0377-4929.91542
Rekhi B, Jambhekar NA. Malignant Transformation in a Hybrid Schwannoma/perineurioma: Addition to the Spectrum of a Malignant Peripheral Nerve Sheath Tumor. Indian J Pathol Microbiol. 2011 Oct-Dec;54(4):825-8. PubMed PMID: 22234123.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Malignant transformation in a hybrid schwannoma/perineurioma: addition to the spectrum of a malignant peripheral nerve sheath tumor. AU - Rekhi,Bharat, AU - Jambhekar,Nirmala A, PY - 2012/1/12/entrez PY - 2012/1/12/pubmed PY - 2012/4/13/medline SP - 825 EP - 8 JF - Indian journal of pathology & microbiology JO - Indian J Pathol Microbiol VL - 54 IS - 4 N2 - Benign nerve sheath tumors include schwannomas, neurofibromas and perineuriomas. The malignant counterpart of a nerve sheath tumor is designated as a malignant peripheral nerve sheath tumor (MPNST). Lately, benign nerve sheath tumors comprising more than one component have been described, including hybrid schwannomas/perineuriomas. However, malignant transformation in a hybrid schwannoma/perineurioma has not been documented so far. Herein, we present a rare case of a young adult male who presented with a soft tissue mass in his right thigh that was excised elsewhere and submitted to us for histopathological review. One of the tissue sections displayed histopathological features of a hybrid schwannoma/perineurioma, including alternate arrangement of benign schwann and perineurial cells, reinforced with S100-P and epithelial membrane antigen positivity, respectively, along with low MIB1 and negative p53 immunostaining. The other two tissue sections showed a spindly sarcomatous tumor that was immunohistochemically positive for S100-P, CD34, p53 and exhibited high MIB1 (30-40%). Diagnosis of a MPNST arising in a hybrid schwannoma/perineurioma was made. This unusual case forms yet another addition to the spectrum of a MPNST. SN - 0974-5130 UR - https://www.unboundmedicine.com/medline/citation/22234123/Malignant_transformation_in_a_hybrid_schwannoma/perineurioma:_addition_to_the_spectrum_of_a_malignant_peripheral_nerve_sheath_tumor_ L2 - http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=4;spage=825;epage=828;aulast=Rekhi DB - PRIME DP - Unbound Medicine ER -